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David Riglar Profile
David Riglar

@driglar

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PI and Sir Henry Dale Research Fellow at Imperial College London and The Francis Crick Institute. Also at: https://t.co/2Zcfv9OQjo

London, UK
Joined April 2011
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@driglar
David Riglar
1 year
So happy to share the amazing work of @CarrenoYugueros using #synbio engineered bacteria to sense #microbiome nutrient availability in the gut with beautiful microscopy. @IC_CSynBio @ImperialInfect & @TheCrick. https://t.co/XTaxvio82L
@CarrenoYugueros
David Carreno Yugueros
1 year
Super proud to share our latest pre-print with @driglar 🎉 ! Using an engineered bacterial biosensor 🦠 we monitored sialic acid (an important metabolite for gut microbes) in the gut.
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@ImperialMed
Imperial Medicine
3 months
We’re looking for an exceptional academic leader with a compelling vision to Head @ImperialInfect at @imperialcollege. Apply by 15 September 2025
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@ICStructBio
Structural and Synthetic Biology
3 months
We are offering comprehensive fellowship support and an outstanding research environment @imperialcollege @ImperialInfect @ICStructBio https://t.co/GHNdoOQ95I
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@driglar
David Riglar
4 months
Excited to share our labs latest paper. We use #synbio for biosensor discovery to aid our quest to build 'smart probiotics' to sense and treat disease. Well done @KlondikeClare et al! Thanks @wellcometrust for funding! https://t.co/GpfB6IefH5 @ImperialInfect @TheCrick
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embopress.org
imageimageA screen for inducible biosensing components to drive a bacterial synthetic memory circuit is designed using barcoded libraries of sensory systems. Testing and validation in conventional...
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@driglar
David Riglar
1 year
📢 A fully-funded PhD position for UK-home student📢 Want to apply #synbio to understand the gut #microbiome in disease? Join the Riglar lab for your PhD! @ImperialInfect & @theCrick. Email CV, cover letter and details of 2 refs by 6th Sept to apply https://t.co/qKcnJ3mkhY
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findaphd.com
PhD Project - Synthetic biosensors to understand the gut microbiome at Imperial College London, listed on FindAPhD.com
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@driglar
David Riglar
1 year
Hey @gibbological, have you seen the @nytimes Spelling Bee today?
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@ravinash_kk
Ravinash Krishna Kumar
2 years
Few more days to apply for the PDRA position closing end of Jan!
@ravinash_kk
Ravinash Krishna Kumar
2 years
📢1x PDRA & 1 x PhD position available 📢 @ImperialInfect, @imperialcollege Building minimal gut microbiome models using 3D printing & fluidics 🖨🦠🤖 PhD deadline : 12 th of January 2024 (home fees) PDRA deadline: 30 th of January 2024 Apply 👇 https://t.co/cb98y6e0V5
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@driglar
David Riglar
2 years
📢PhD positions: last day to apply📢 1x fully-funded for UK-home student https://t.co/iMf0gikWzA Also option to sponsor int'l students for scholarship - incl https://t.co/w2Eye02QiR. Send CV incl past grades, cover letter and details of 2 refs by email.
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imperial.ac.uk
Information about these fully-funded scholarships for PhD applicants of any nationality at Imperial.
@driglar
David Riglar
2 years
Want to apply #synbio to understand the gut #microbiome in disease? Join the Riglar lab for your PhD! 1x funded position for UK home students. Can also sponsor 1x intl student for scholarship. Apply by 8th Dec. Details👇and https://t.co/KeYJtOs4zY. @ImperialInfect & @theCrick.
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@thelowlab
Harry Low’s Lab
2 years
Exciting faculty opportunity to join our structural biology community at Imperial College, London!! We are recruiting an EM junkie at Lecturer or Senior Lecturer or Reader level. Please RT! https://t.co/rCyAw8giOm
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imperial.ac.uk
Join Imperial and be part of a world leading community of research, teaching and innovation.
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@ravinash_kk
Ravinash Krishna Kumar
2 years
📢Phd position available 📢 @ImperialInfect, @imperialcollege working on 3D printing of anaerobic bacterial communities. 🦠🖨 Deadline: 12 th of January 2024 Home fees. International – Presidents Scholarship ( https://t.co/CZ1rUDz9VJ) Apply:
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@driglar
David Riglar
2 years
To apply please send cover letter detailing why you are interested in the lab, CV and 2 references via email.
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@driglar
David Riglar
2 years
Want to apply #synbio to understand the gut #microbiome in disease? Join the Riglar lab for your PhD! 1x funded position for UK home students. Can also sponsor 1x intl student for scholarship. Apply by 8th Dec. Details👇and https://t.co/KeYJtOs4zY. @ImperialInfect & @theCrick.
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@driglar
David Riglar
2 years
#synbio people - are there any examples of published results from public consultation on the idea of delivering synthetic engineered organisms/cells to patients in the clinic?
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@ProfTomEllis
Tom Ellis
2 years
Come be a PI with me... our continually-awesome Bioengineering Dept is hiring for up to 4 new faculty members, including in synthetic biology and molecular bioengineering. #SynBio | Pls RT
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imperial.ac.uk
Join Imperial and be part of a world leading community of research, teaching and innovation.
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@driglar
David Riglar
2 years
We are very grateful to funding from @wellcometrust. And welcome any feedback from the community to further improve the work.
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@driglar
David Riglar
2 years
Along the way we learn a lot about testing pools of engineered bacteria in the mammalian gut. And simplify the process of library design and construction. This leaves us ready to look for unique biosensors from a wider range of bacterial sources for more diverse applications 8/n
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@driglar
David Riglar
2 years
Does it work? Yes! With the platform we identify a new sensor to tetrathionate - an inflammatory biomarker. We also find a sensor that responds to citrate within the gut. 7/n
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@driglar
David Riglar
2 years
We add barcodes to each sensor during construction in a one-pot reaction. Its is cheap to construct and sequence, gives us flexibility to have varied sensors and ongoing revision of our library, and allows us to test sensor replicates for more robust results. 6/n
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@driglar
David Riglar
2 years
How does it work? When a biosensor fires in our engineered E. coli, the #synbio memory circuit switches on - causing resistance to an antibiotic. We identify interesting sensors from a pool of candidates using differential antibiotic resistance and sequencing 5/n
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