David Riglar
@driglar
Followers
992
Following
815
Media
28
Statuses
644
PI and Sir Henry Dale Research Fellow at Imperial College London and The Francis Crick Institute. Also at: https://t.co/2Zcfv9OQjo
London, UK
Joined April 2011
So happy to share the amazing work of @CarrenoYugueros using #synbio engineered bacteria to sense #microbiome nutrient availability in the gut with beautiful microscopy. @IC_CSynBio @ImperialInfect & @TheCrick. https://t.co/XTaxvio82L
Super proud to share our latest pre-print with @driglar 🎉 ! Using an engineered bacterial biosensor 🦠we monitored sialic acid (an important metabolite for gut microbes) in the gut.
0
6
23
We’re looking for an exceptional academic leader with a compelling vision to Head @ImperialInfect at @imperialcollege. Apply by 15 September 2025
1
5
14
We are offering comprehensive fellowship support and an outstanding research environment @imperialcollege @ImperialInfect @ICStructBio
https://t.co/GHNdoOQ95I
0
2
3
0
0
0
Excited to share our labs latest paper. We use #synbio for biosensor discovery to aid our quest to build 'smart probiotics' to sense and treat disease. Well done @KlondikeClare et al! Thanks @wellcometrust for funding! https://t.co/GpfB6IefH5
@ImperialInfect @TheCrick
embopress.org
imageimageA screen for inducible biosensing components to drive a bacterial synthetic memory circuit is designed using barcoded libraries of sensory systems. Testing and validation in conventional...
1
4
15
📢 A fully-funded PhD position for UK-home student📢 Want to apply #synbio to understand the gut #microbiome in disease? Join the Riglar lab for your PhD! @ImperialInfect & @theCrick. Email CV, cover letter and details of 2 refs by 6th Sept to apply https://t.co/qKcnJ3mkhY
findaphd.com
PhD Project - Synthetic biosensors to understand the gut microbiome at Imperial College London, listed on FindAPhD.com
1
14
18
Few more days to apply for the PDRA position closing end of Jan!
📢1x PDRA & 1 x PhD position available 📢 @ImperialInfect, @imperialcollege Building minimal gut microbiome models using 3D printing & fluidics 🖨🦠🤖 PhD deadline : 12 th of January 2024 (home fees) PDRA deadline: 30 th of January 2024 Apply 👇 https://t.co/cb98y6e0V5
0
1
1
📢PhD positions: last day to apply📢 1x fully-funded for UK-home student https://t.co/iMf0gikWzA Also option to sponsor int'l students for scholarship - incl https://t.co/w2Eye02QiR. Send CV incl past grades, cover letter and details of 2 refs by email.
imperial.ac.uk
Information about these fully-funded scholarships for PhD applicants of any nationality at Imperial.
Want to apply #synbio to understand the gut #microbiome in disease? Join the Riglar lab for your PhD! 1x funded position for UK home students. Can also sponsor 1x intl student for scholarship. Apply by 8th Dec. Details👇and https://t.co/KeYJtOs4zY.
@ImperialInfect & @theCrick.
0
4
9
Exciting faculty opportunity to join our structural biology community at Imperial College, London!! We are recruiting an EM junkie at Lecturer or Senior Lecturer or Reader level. Please RT! https://t.co/rCyAw8giOm
imperial.ac.uk
Join Imperial and be part of a world leading community of research, teaching and innovation.
0
34
29
📢Phd position available 📢 @ImperialInfect, @imperialcollege working on 3D printing of anaerobic bacterial communities. 🦠🖨 Deadline: 12 th of January 2024 Home fees. International – Presidents Scholarship ( https://t.co/CZ1rUDz9VJ) Apply:
1
14
29
To apply please send cover letter detailing why you are interested in the lab, CV and 2 references via email.
0
0
0
Want to apply #synbio to understand the gut #microbiome in disease? Join the Riglar lab for your PhD! 1x funded position for UK home students. Can also sponsor 1x intl student for scholarship. Apply by 8th Dec. Details👇and https://t.co/KeYJtOs4zY.
@ImperialInfect & @theCrick.
2
46
81
Come be a PI with me... our continually-awesome Bioengineering Dept is hiring for up to 4 new faculty members, including in synthetic biology and molecular bioengineering. #SynBio | Pls RT
imperial.ac.uk
Join Imperial and be part of a world leading community of research, teaching and innovation.
2
60
120
We are very grateful to funding from @wellcometrust. And welcome any feedback from the community to further improve the work.
0
1
2
Along the way we learn a lot about testing pools of engineered bacteria in the mammalian gut. And simplify the process of library design and construction. This leaves us ready to look for unique biosensors from a wider range of bacterial sources for more diverse applications 8/n
1
1
1
Does it work? Yes! With the platform we identify a new sensor to tetrathionate - an inflammatory biomarker. We also find a sensor that responds to citrate within the gut. 7/n
1
0
1
We add barcodes to each sensor during construction in a one-pot reaction. Its is cheap to construct and sequence, gives us flexibility to have varied sensors and ongoing revision of our library, and allows us to test sensor replicates for more robust results. 6/n
1
0
1