César Serrano García
@DrCeSarcoma
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Physician-scientist · #sarcoma #GIST @VHIO | External Group Leader @IRBBarcelona | #SanidadPública | #SinCienciaNoHayFuturo | @MyEsmo Faculty. Tweets are my own
Barcelona / de Salamanca
Joined June 2018
🤩 Ha sido todo un honor recibir la beca CRIS de Excelencia dotada con 1.25M€ para diseccionar a un nivel sin precedentes los mecanismos moleculares de los #Sarcomas #GIST - y poder avanzar en el tratamiento de nuestros pacientes 🧬💊 🙏🏼 Muchas gracias a la #CRIScontraelcáncer
🔴 Para el Dr. @DrCeSarcoma del @VHIO de Barcelona por el Proyecto CRIS de Sarcomas Gastrointestinales. ➡️ Entrega el Dr. Kevin Harrington, jefe del servicio de Radioterapia e Imagen del @CTI_ICR. #CRIScontraelcáncer #OtraOportunidad #DíaCienciaCRIS24
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This paper from Harvard and MIT quietly answers the most important AI question nobody benchmarks properly: Can LLMs actually discover science, or are they just good at talking about it? The paper is called “Evaluating Large Language Models in Scientific Discovery”, and instead
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This article suggests that cancer treatment contributes to mutagenesis: "More than 25% of driver mutations in normal tissue exposed to systemic anti-cancer therapy, including in TP53, could be attributed to treatment."
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DART hits the rare cancers target over and over. Nivolumab plus ipilumumab in PECOmas 🎯🎯 https://t.co/c4PlzRtr8x
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Happy to share our latest study @Nature , where we evaluate somatic evolution and the effect of treatment in normal tissue using duplex sequencing 1/n https://t.co/fr1Cbj7SDU
nature.com
Nature - High-depth sequencing of non-cancerous tissue from patients with metastatic cancer reveals single-base mutational signatures of alcohol, smoking and cancer treatments, and reveals how...
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Nunca tendré suficientes palabras de agradecimiento para este tipo de iniciativas. La #investigación en #sarcomas la hacemos entre todos 🫂
Hoy queremos dar las gracias a Lucía López, paciente de @DrCeSarcoma, que convirtió su 50 cumpleaños en una iniciativa solidaria para apoyar la investigación en #sarcoma en el VHIO, recaudando 1.835 €. 💙 ¡Gracias por tu compromiso, generosidad y solidaridad!
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Congratulations, David Gómez (@dgomezpere)‼️ On defending his thesis: “The genomic landscape of gastrointestinal stromal tumor progression uncovers the role of chromosomal instability in the cytogenetic and clinical evolution of the disease.” 👏 An outstanding achievement driven
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👨🎓📄 3rd PhD from my #sarcoma lab at @VHIO Congratulations to Dr. David Gómez-Peregrina @dgomezpere 📣 Stay tuned to his terrific computational work on #GIST - sending out soon-ish!
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📢📢 Hot off the press: trabectedin+olaparib vs trabectedin in advanced STS just published in @Annals_Oncology‼️ ⚠️Marginal benefit in all comers 🔬🧬Meaningful activity in uLMS and PARP1+ve STS. An outstanding collaboration of the @ItaSarcomaGroup ! https://t.co/ARsVyxL7wi
annalsofoncology.org
Advanced/metastatic soft tissue sarcomas (STS) remain an unmet clinical need. We previously reported the feasibility and preliminary activity of trabectedin-olaparib combination in patients with...
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Germline testing in sarcoma (N=115) 🧩 PGVs in 8.7% → TP53, BRCA1, SDHA, ATM, NBN ⚠️ 70% of PGVs would NOT be detected by current guidelines 📈 Highlights the value of broad-panel germline testing to guide therapy + familial risk assessment 🔗 https://t.co/EK3mNplyeA
@OncoAlert
mdpi.com
Sarcomas are rare heterogenous mesenchymal tumors with over seventy-five different subtypes, with varying biology and outcomes, with no clear inciting factor in the vast majority. To determine the...
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🥹Siempre me faltará encontrar las palabras suficientes de agradecimiento para familias como la de Fernando, Ozelot, por su compromiso con la ciencia y con la investigación en #sarcomas GRACIAS Su música 🎶👇 Spotify: https://t.co/AftqUHwQCd Apple Music: https://t.co/diZwtBgfIX
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In my humble opinion, the next generation of reviews must be more forward-thinking and give personal views on the topic. This would make our works truly unique By the way: everyone shows their concerns with AI, but not with medical writers taking over our duty of writing science
🆕 Editorial article in press: “Will AI write the next "Chapter" in literature reviews?” 👉 https://t.co/aJhaA9HPUc
@Prof_Koopman
@mihaela_aldea
@jnkath
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Sensitive and timely call for patient selection and non-reflex NGS testing in patients with sarcoma, applicable to other rare condiditions 🔸Importance of expect centers 🔸Pathology Review 🔸Findings and context by @DrCeSarcoma @jeanyvesblay Dr Sebastien Bauer Link:
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OMG 😱 Scientific evidence demonstrate that RT-induced abscopal effect does NOT exist 👇🏼👇🏼👇🏼
A new Nature paper just delivered a shock to a long-lived oncology myth. 🔗 https://t.co/JMaFE9Ezco For years we’ve been told that radiotherapy—and its cousins like SBRT, TARE, Y-90—might trigger the “abscopal effect,” a systemic immune response that helps control distant
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Register for the Virtual healthbook CME Webinar - GIST: Moving Toward Tailored Therapies and ctDNA-Guided Decisions, Wednesday, Nov 26, 2025 - 17:00 – 18:25 CET https://t.co/TPcOb5Ohzo
#sarcoma #ctDNA #GISTeducation
@DrCeSarcoma
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🚨Historical presentation at #CTOS2025 ChonDRAgon - first positive randomised trial in chondrosarcoma 🔹Ozekibart vs placebo 🔹 mPFS 5.52 vs 2.66 months 🔹 HR 0.479; p<0.0001 🔹 a manageable safety profile - most common TRAE: fatigue, diarrhea, and nausea
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Comenzamos #SEOM25 👇🏼
Con el lema «Frente al Cáncer, Ciencia y Cuidado», arranca #SEOM25: ➕️ 1.800 congresistas. 🗣 306 ponentes. 🩺 60 mesas científicas. 🥼 Talleres prácticos. ♻️ Congreso sostenible. 🔗 Comparte ideas y experiencias con el hashtag oficial #SEOM25 💻 https://t.co/xuQhCafVnL
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In this manuscript in @CD_AACR, we investigate target-mediated resistance to ADCs, and propose ways to overcome it. https://t.co/bUSy4zqw1N
aacrjournals.org
Abstract. T-DXd is clinically beneficial in HER2 positive and HER2 low metastatic breast cancer. However, therapeutic resistance emerges over time in most patients, with poorly defined resistance...
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Si ya estás preparando la 🧳, no olvides tus 👟👟 Movimiento @_SEOM #EjercicioContraElCancer 🗓️11 a 14 de Noviembre‼️ 📍🏨Meliá Castilla (Madrid) 🚴🏼o🏃♀️ y tus Km sumarán💲para una Beca SEOM'26‼️ https://t.co/rALPpWqn0c
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We’re thrilled to see positive Phase 3 top-line results from Cogent's PEAK trial of bezuclastinibin combination with sunitinib, the first potential new second-line treatment option for GIST in nearly 20 years. Read their letter to patients here:
acrobat.adobe.com
Click or tap to view this file.
Today we shared landmark results from our Ph 3 PEAK trial in #GIST. We are deeply grateful 2 the patients, families & researchers whose participation helped make this possible. Read the release: https://t.co/oqVlBy1OZI . Join our webcast at 8am ET: https://t.co/ZfgP1yA1bo
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