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Dr. Kat Wollenberg Valero Profile
Dr. Kat Wollenberg Valero

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cold blooded 🐸🦎🐟 🦀 🪱, climate adaptation genomics & stress response PI #ERC_CoG #MolStressH2O @OdysysLab @UCDDublin @Cassandragenes

Dublin, Ireland
Joined January 2014
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@cybokat
Dr. Kat Wollenberg Valero
4 months
In the @ERC_Research .funded #MolStressH2O project at.@OdysysLab, we’re exploring how aquatic animals deal with climate stressors. From altered DNA repair in baby fish 🐟 to chemical stress signals that ripple through entire communities 🌊, it’s going to be a wild ride.
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@cybokat
Dr. Kat Wollenberg Valero
6 months
RT @lpachter: The exciting reveal of Ultima Genomics last week was accompanied by the publication of four preprints. Intrigued by the poten….
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biorxiv.org
We analyze single-cell RNA-seq data sequenced with Ultima Genomics technology and find high error rates in and near homopolymers. To compensate for these errors, we explore the use of pseudoalignment...
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@cybokat
Dr. Kat Wollenberg Valero
7 months
However, this adaptation came at a cost: a population crash evidenced by a steady decline in genetic diversity throughout the study period :(.
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Dr. Kat Wollenberg Valero
7 months
In particular, we suspect that a system called Ahr::Arnt, which regulates gene activation in response to stress, has been shaped by natural selection, likely because it offered advantages in the hotter, drier conditions.
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@cybokat
Dr. Kat Wollenberg Valero
7 months
(the image shows increase in heat events on Tenerife based on data obtained by @AEMET_Esp as red bars). This heatwave occurred just as the lizard cohort we studied had hatched, demonstrating how quickly natural selection can act within a single generation.
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@cybokat
Dr. Kat Wollenberg Valero
7 months
Over time, lizards accumulated previously rare genetic variants while rapidly purging others. We could tie a drastic shift in the genetic makeup of promoter sequences to a severe heatwave and drought in 2017.
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@cybokat
Dr. Kat Wollenberg Valero
7 months
We found that certain genes involved in water balance and energy use, such as aquaporins and the mitochondrial ETFA, play key roles in adapting to local climates, which range from hot and dry to cold and humid.
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@cybokat
Dr. Kat Wollenberg Valero
7 months
We focused on specific parts of their DNA, called gene promoters, which control how genes are turned on or off, in a set of genes previously linked to climate adaptation in animals.
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@cybokat
Dr. Kat Wollenberg Valero
7 months
In this study, we examined how the Western-Canaries lizard, Gallotia galloti, adapted to different environments on Tenerife and how these adaptations evolved over the past nine years.
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@cybokat
Dr. Kat Wollenberg Valero
7 months
Climate change pushes animals to respond in various ways, but we still don’t fully understand whether and how their DNA changes to help them cope.
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@cybokat
Dr. Kat Wollenberg Valero
7 months
New preprint just out led by Ed Gilbert @OdysysLab on genetic basis of #climatechange adaptation in lizards🧵
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@cybokat
Dr. Kat Wollenberg Valero
7 months
RT @TAKosch: Check out our new preprint on the first frog SNP array we designed to help improve conservation efforts for corroboree frogs.….
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@cybokat
Dr. Kat Wollenberg Valero
8 months
RT @KRuthsatz: 🐸🌡️☣️In our new paper in @J_Exp_Biol we investigated the interactive effects of thermal stress and n….
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@cybokat
Dr. Kat Wollenberg Valero
8 months
If @HelenBranswell is picking up the H5N1 coverage we should all get concerned 😧.
@HelenBranswell
Helen Branswell 🇨🇦
8 months
British Columbia health officials close their investigation for now into how a teenager contracted #H5N1 #birdflu because they've exhausted all leads. Genetic evidence points to a possible wild bird exposure. The teen is showing some signs of progress.
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@cybokat
Dr. Kat Wollenberg Valero
8 months
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@cybokat
Dr. Kat Wollenberg Valero
9 months
next time get permission from publisher and ask me, I'll be happy to supply a non pixely version.
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@cybokat
Dr. Kat Wollenberg Valero
9 months
Thanks to the authors for "adopting" aka copy pasting our figure for their paper 😂. Typically for this they would have needed to get permission from the actual publisher (@WileyGlobal ). But maybe we aren't doing this anymore 🤷‍♀️
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@cybokat
Dr. Kat Wollenberg Valero
9 months
RT @TAKosch: Exciting news for the AGC—our first paper is now published in BMC Genomics! Check it out here: https:/….
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@cybokat
Dr. Kat Wollenberg Valero
9 months
RT @OdysysLab: Our new paper is out where we officially introduce the #Amphibian #Genomics Consortium and analyse gaps in knowledge and rep….
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