Costi Sifri, MD
@costisifri
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@UVA Infectious Diseases Physician. Drug resistance, epidemiology & compromised hosts. Trail/ultrarunner when life allows.
Charlottesville
Joined January 2014
Can’t say it better than @LisaIDpharmD! IDWeek 2024 is shaping up to be a great meeting. Huge thanks and kudos to this amazing @SHEA_Epi & @SIDPharm ‘N&S’ (Epi and Stewardship) Team 🙏🏼😊. #SeeYouInLA @IDWeekmtg @IDSAInfo.
The @IDWeekmtg Planning Committee was hard at work this week planning the 2024 meeting! Excited for next year’s program, for the time spent with this amazing team, & to represent @SIDPharm on the committee! Looking forward to seeing everyone in L.A!
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RT @TaisonBell: 🚨New Paper Alert!🚨. Is it true that transplant patients respond differently to bloodstream infection (BSI)? 🤔 We explored t….
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RT @CIDJournal: Pathophysiological responses to bloodstream infection in critically ill transplant recipients compared to non-transplant re….
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RT @SHEA_Epi: IDWeek 2024 is a wrap! Huge thank you to Dr Belinda Ostrowsky this year’s amazing SHEA chair! Hope you are as inspired as we….
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Thank you for the fantastic talks @TStosor and Veronica Dioverti. You both highlighted how much we’ve learned through the SARS-CoV-2 pandemic and how much more we need to learn in order to provide outstanding care to our immunocompromised patients.
@DrJLi @IDWeekmtg @costisifri Amazing experience to team up with @DrJLi @costisifri and Veronica Dioverti! Thanks you for the opportunity @IDWeekmtg!.
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RT @DrJLi: Just moderated a great @IDWeekmtg session with @costisifri on Complex COVID Management Issues in Special Populations with two am….
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RT @dr_dmorgan: Thrilled this is out!. Improving antimicrobial use through better diagnosis: .The relationship between diagnostic stewardsh….
cambridge.org
Improving antimicrobial use through better diagnosis: The relationship between diagnostic stewardship and antimicrobial stewardship - Volume 44 Issue 12
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RT @Tuliodna: With all of due respect, there is absolute NO CONCERN of Omicron EG.5 in South Africa or most of the world. It would be a goo….
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RT @UvaDOM: Join us Friday at 12pm in the ERC or via Zoom for Medicine Grand Rounds. Our guest will be UVA's Dr. Patrick Jackson, speaking….
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Although donor-derived HAV infection is a rare event (only 2 prior reports in the lit.), it may be under-recognized due to the self-limited nature of hepatitis A. However, given the marked increase in HAV in the US over the last decade, this risk may be increasing. fin/.
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The best preventative measure is to make sure transplant candidates (and recipients) have received HepA vaccination. As always, it's better to vaccinate BEFORE transplant than after. 9/.
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Lab-based screening for HAV is unlikely to be useful because:.1. PPV of screening anti-HAV IgM in only 10% in asx ppl.2. Mean HAV incub period = 28d (15-45d). Donors with acute HAV may be infectious but undetectable during this window period.3. No commercial HAV RNA test.8/.
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The recipient of the donor liver had evidence of immunity to HAV and did not become infected. 7/.
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Fortunately both kidney transplant recipients made a full recovery with supportive care. HAV was detectable in serum +/- stool 176 and 189 days post transplant in the two recipients. 6/.
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The recipients developed symptomatic hepatitis A 19 and 75 days post-transplant with high HAV VLs detected in serum and stool. Banked donor serum also proved to be HAV RNA positive (2.6 million IU/mL). Genomic analysis showed that all were infected with the same HAV strain. 5/.
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* The donor had potential risks for HAV exposure and reportedly had a recent fever but had no GI issues, jaundice, LFT abnormalities, or other signs/symptoms of acute hepatitis A prior to organ procurement. 4/.
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Like many DDI cases, much can be learned from this event. The report details hepatitis A virus (HAV) transmission from a pauci-symptomatic*, likely acutely infected donor to two kidney transplant recipients. @AST_IDCOP #TxID #TransplantID.3/.
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First, the authors dedicate this report to co-author, Dr. Avinash Agarwal. Dr. Agarwal was a fantastic transplant surgeon, physician-scientist, and former DTAC committee member. Avi was also my close friend and colleague. He is greatly missed. 2/.
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Proud of this report of hepatitis A donor derived infection (DDI) pub'd in Transplantation Direct, a thread. @TXPDirect @uvatransplant @UVA_ID @UofLHealth @CDCgov .1/. Donor-derived Transmission of Hepatitis A Virus Following. : Transplantation Direct
journals.lww.com
line for HAV incubation and clearance in transplant recipients is not well understood. Methods. In 2018, 2 kidneys and a liver were procured from a deceased donor resident of Kentucky, one of many...
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