TransplantDirect
@TXPDirect
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Transplantation Direct is an open access journal for international transplantation content. It is Transplantation's companion journal.
Joined October 2014
The August issue of.@TXPDirect. is jam-packed with useful information for our diverse international transplantation readership. We welcome you to visit our Transplantation Direct website for full details in open-access. #OpenAccess #TransplantTwitter
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Survey of 8 abdominal transplant centers finds major variation in referral screening, waitlist maintenance & follow-up. Only 25% have formal appeal for declined patients. Standardizing processes may improve data quality & outcomes. #TXPforAll
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Scarcity of size-matched donor lungs limits pediatric & small adult lung transplants. Study reports 4 consecutive cases of split heterotopic bilateral lobar Lung Tx—maximizing donor lung use & expanding options for this high-need group. #TXPforAll
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In a porcine model, key genes (IL6, THBS1, MIR-21) were linked to early ischemia/reperfusion injury, offering new targets for therapies to reduce graft damage. @DrSamratRay #TXPforAll #Transplantation #OpenAccess
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Closing the abdominal wall after organ transplant can be complex. A global survey shows nonvascularized rectus fascia transplant is a viable long-term option—low herniation, no graft rejection, and manageable complications. #TransplantSurgery
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Patterns of lactate clearance during warm machine perfusion of donor livers can predict biliary complications after liver transplant from donors after circulatory death. Prolonged lactate elevation was linked to higher complication risk. #TXPforAll
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According to Wijesinha et al., carefully increasing the use of older donors can reduce waitlist deaths while maintaining strong outcomes.@NorthwellHealth #TXPforAll #LungTransplantation #OpenAccess
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Can short-term HMP improve pancreas preservation? In a preclinical DCD model, 2h of hypothermic machine perfusion (HMP) before NMP improved oxygenation & reduced resistance indices vs. static cold storage. No added endothelial damage observed. #TXPforAll
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The July issue of.@TXPDirect. is jam-packed with useful information for our diverse international transplantation readership. We welcome you to visit our Transplantation Direct website for full details in open-access. #OpenAccess #TransplantTwitter
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Adherence matters! In the Kidney Transplantation 360° study (n=838), adherence to immunosuppressants improved over 3 years with a structured aftercare program. A "catch-up effect" was seen in younger, male patients further out from transplant. #TxpforAll
journals.lww.com
for up to 3-y duration of the Kidney Transplantation 360° study. Additionally, we examined putative baseline predictors of adherence trajectories. During the investigation period, patients particip...
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DBD to DCD donation pathway. Among eligible brain-dead donors, some proceed via circulatory death—mostly due to family wishes to witness asystole. Outcomes? Comparable graft survival, with reduced delayed graft function vs standard DCD
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3D laparoscopic ileal resection shows promise in living donor small bowel transplantation! In 7 parental donors, this minimally invasive approach led to safe recovery, normal bowel function, and high donor satisfaction at 6 months #TXPforAll
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A stable and feasible baboon model for orthotopic liver transplantation has been established—overcoming limitations of existing primate models and paving the way for translational advances in ischemia- and tolerance-free transplant research
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GREAT CASE REPORT by Chen, reported the successful treatment of post-transplant thrombotic microangiopathy in a simultaneous pancreas-kidney recipient with plasmapheresis, #eculizumab, and a CNI/mTORi-free regimen.
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New strategy for GvHD in pediatric small intestinal transplant: Switching from immunosuppression intensification ➡️ reduction significantly improved survival. Linked to changes in T-cell chimerism—possibly tipping the balance toward host-versus-graft
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Most popular paper this month! In a national kidney transplant cohort (n = 242K), obesity defined by both BMI and BSA was linked to significantly higher risks of graft loss and delayed graft function. #KidneyTransplantation #Obesity #TXPforAll #OpenAccess
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In lung transplant recipients, even small gains in physical function (via LT-VLA) linked to better quality of life, lower CLAD risk (↓13%), and reduced mortality (↓19%). LT-VLA may be a simple yet powerful tool for post-transplant monitoring
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Check this study of around 242K kidney transplants, where obesity defined by both BMI & BSA was linked to higher graft loss & delayed graft function vs BMI alone. Dual-parameter obesity may better flag high-risk recipients
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This study of 1803 kidney transplant recipients, where 35% showed nonadherence in the first year—linked to worse graft outcomes. Psychiatric history and prior nonadherence were key risk factors. Simple monitoring can help flag high-risk patients
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This study by Baan et al. reports that kidney-derived urinary extracellular vesicles (KD-uEVs) are promising noninvasive biomarkers for the early diagnosis of acute rejection. #Transplantation #TXPforAll #OpenAccess
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