Catherine Schretter @[email protected]
@ceschretter
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Postdoc in Rubin lab @HHMIJanelia | Neuronal circuitry underlying social behaviors | Host-microbe interactions | PhD @Caltech | she/her
Virginia, USA
Joined September 2018
Excited to release this new pre-print ( https://t.co/kO7APZiTXw)🎉 In a complex visual environment, how do flies (like below) know what to focus on? We uncovered neuronal pathways through which social states (like aggression🥊 and courtship) modulate visual processing. 1/
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I’m so excited and honored to be included in this new cohort of #HannaGrayFellows!! I can’t wait to get to know this community of outstanding scientists and advance our research together!
Today we're thrilled to announce our 2024 #HannaGrayFellows! Please join us in welcoming and celebrating these outstanding early career scientists! This cohort includes scientists working in research areas ranging from treatment-resistant cancers to sleep dysregulation to how
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Finally, its out on biorxiv. Our labs collaboration with Rubin lab@Janelia building CX specific cell types, determining their neurochemical identities and screening them for sleep phenotypes. 7 years in making and hopefully a great resource for the community.
Cell type-specific driver lines targeting the Drosophila central complex and their use to investigate neuropeptide expression and ... https://t.co/jWM5pqoxVe
#biorxiv_neursci
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Looking forward to presenting and talking with everyone tomorrow. Thanks for having me!
Aggressive fruit flies? Find out more about it in our next "Emerging Scientist Talk" on neural circuits underlying aggression in Drosophila by Katie Schretter @ceschretter, postdoc @HHMIJanelia. Tomorrow, October 21, at 11am in NQ 105 in Martinsried! Art by @mulesome
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Excited to share our new preprint on connectomic analysis of fly taste circuits! We used the connectome to identify neurons and brain regions involved in taste processing, compare properties of neurons that process different tastes, and more!
biorxiv.org
Our sense of taste is critical for regulating food consumption. The fruit fly Drosophila represents a highly tractable model to investigate mechanisms of taste processing, but taste circuits beyond...
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🦟New research led by Sr. Group Leader David Stern & Research Scientist Hiroshi Shiozaki examines neural activity in singing fruit flies to understand how neurons in the fly nerve cord produce fly courtship songs. ➡️ https://t.co/eMpxQ0B8yp Learn more ➡️ https://t.co/2bvuxmfKjZ
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Sex or survival—what’s more important? Excited to share our @Nature paper on how flies resolve this conflict. We found a dopamine-based filter that reduces threat perception, helping flies focus on courtship when close to mating. https://t.co/ZZ0UoKTqgn
nature.com
Nature - A state-dependent dopamine filter system in the male Drosophila brain balances threat perception against the drive to mate.
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Excited to share the first Rogers lab paper is officially out at Nucleic Acids Research! https://t.co/Uj16f9B4nu RNAi pathways maintain robust coordination of other RNAi pathways during stress, ultimately ensuring proper sperm function 🔥Congrats @trilotma and @cara_mccormick!
academic.oup.com
Abstract. Coordination of gene regulatory networks is necessary for proper execution of cellular programs throughout development. RNA interference (RNAi) i
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This one is very close to my heart, proudly sharing our newest preprint “Comparative connectomics of the descending and ascending neurons of the Drosophila nervous system: stereotypy and sexual dimorphism”. A short summary of this project that was 4 years in the making:
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the lab is recruiting scientists @HHMIJanelia! we are particularly excited about engineering fluorescent proteins and biosensors using high-throughput assays and machine learning. questions? please get in touch!
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Very happy to share that @rituja14's work on the nutritional state-dependent modulation of #insulin-producing cells in #Drosophila is out on bioRxiv: https://t.co/mMze44tKy1. Rituja was the 1st person to join the lab and it’s a privilege to accompany her on her PhD journey.
biorxiv.org
Insulin plays a key role in regulating metabolic homeostasis across vertebrate and invertebrate species. Drosophila Insulin-Producing Cells (IPCs) are functional analogues to mammalian pancreatic...
I am excited to share that our preprint “Nutritional state-dependent modulation of Insulin-Producing Cells in Drosophila” is now available on BioRxiv. A thread🧵
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In our latest preprint, we use connectomics to uncover that the FeCO, the largest somatosensory organ in the fly leg, is not only proprioceptive, but also has a subset of sensory neurons that are dedicated to sensing external substrate vibrations as well:
biorxiv.org
Somatosensory neurons provide the nervous system with information about mechanical forces originating inside and outside the body. Here, we use connectomics to reconstruct and analyze neural circuits...
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🧠Janelia scientists have reached another milestone in connectomics: A wiring diagram of the fruit fly visual system. With 50K+ neurons, the optic lobe connectome provides the fullest picture yet of one of the most important parts of the nervous system. https://t.co/wxAk0lZdyp
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The “ORBIT for E. coli” paper is out in Nucleic Acids Research! https://t.co/v4HvqMl3NB **Perform genetics (e.g. deletions) without any PCR / cloning – just transform an oligo!** The paper demonstrates benefits over λ Red & shows how oligos scale to high throughput libraries.
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Many thanks goes to Gerry, our co-authors (Vanessa Ruta, @its__electric, @TSHindmarsh, Nathan Klapoetke, Mei Shao, Aljoscha Nern, @DreherDesign, Dan Bushey, Alice Robie, Adam Taylor, @KristinMBranson) and our wonderful colleagues @HHMIJanelia for all of their help and support!
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Previous work revealed the importance of the same visual feature detectors (LC10a) in male courtship. In a collaboration with Vanessa Ruta and @TSHindmarsh, we found that one of these same pathways is involved in male courtship pursuit as well. 4/
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This was exciting as it suggests this subset alters the flow of visual information in order to continue aggression. Using different methods (connectomics, patch clamp, imaging, behavior), we revealed 3 motifs by which this female aggression subset modulates visual pathways. 3/
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When we were wrapping up our work on a circuit underlying female aggression, we found that ~ 50% of the downstream targets of female aggression neurons (aIPg) receive visual information. 2/
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Check out our latest paper on how human milk oligosaccharides trigger the B. fragilis colonization program in the current issue of Cell Host & Microbe! 🦠 🤱🏻
Featured Article: NanH gives B. frag an early foothold. @buzun_ekaterina @theChuLab show HMOs activate colonization program in a pioneer gut #commensal, B. fragilis. Orchestrated by NanH, program mediates fitness & resilience during vertical transmission https://t.co/ltNvAimB6z
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