How can we prioritise accelerated therapeutic implementation of the "four pillars" of GDMT for diabetes & CKD? -RASi -SGLT2i -ns-MRA -GLP-1RA @mvaduganathan @KatherineTuttl8 & I outline what an "accelerated, risk-based approach" might look like @CircAHA Tweet added by Brendon Neuen @brendonneuen

Brendon Neuen

2 months

How can we prioritise accelerated therapeutic implementation of the "four pillars" of GDMT for diabetes & CKD? -RASi -SGLT2i -ns-MRA -GLP-1RA @mvaduganathan @KatherineTuttl8 & I outline what an "accelerated, risk-based approach" might look like @CircAHA

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ChristosArgyropoulos MD, PhD PharmanukerInChief

@ChristosArgyrop

2 months

@brendonneuen @mvaduganathan @KatherineTuttl8 @CircAHA @georgeinstitute @BrighamFellows @george_clinical Why would one need 3 to 6 months to fully onboard SGLT2I? 3-4 wks are needed to get a new baseline of egfr, then one moves to the nsMRA, which can be prescribed based in CV risk alone. If gfr >45 can start both at the same time. Glp1 can be dropped any time. #pharmanuke

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Brendon Neuen

@brendonneuen

2 months

@ChristosArgyrop @mvaduganathan @KatherineTuttl8 @CircAHA @georgeinstitute @BrighamFellows @george_clinical Completely agree with you - but guidelines & consensus recommendations don't currently advocate such an approach. Instead they suggest monitoring UACR every 3-6 months! Which is not even happening. We need a new framework that prioritises accelerated GDMT uptake for high-risk pts

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Lisandro Marani

@DrLMarani

2 months

@brendonneuen @mvaduganathan @KatherineTuttl8 @CircAHA @georgeinstitute @BrighamFellows @george_clinical Could you please share the full text article?

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