Antonio C Bianco
@Bianco_Lab
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Physician-Scientist, Writer ("Rethinking Hypothyroidism"), and Dean @utmb_jssom. #thyroid, #hypothyroidism, #ThyroidDisease, #EndoTwitter.
Galveston, TX
Joined January 2014
Treatment of Hypothyroidism that Contains T3 is Associated with Reduced Risk of Dementia and Mortality. Results from 1.26 million patients with hypothyroidism, 126 health organizations across 17 countries.
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In episode #373 of The Drive, I sit down with Antonio Bianco, M.D., Ph.D. (@bianco_lab), a world-renowned physician-scientist and expert in thyroid physiology and metabolism. Antonio explores the complex biology of thyroid hormone production, conversion, and regulation.
peterattiamd.com
“Hypothyroidism is not that naive disease that we thought it was. It's a deadly disease. It can affect significantly the quality of life of patients." —Antonio Bianco
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Great work by @FedeSalasLucia !!!!!
Thyroid hormones are important for neurodevelopment during the first trimester of pregnancy. Here, @FedeSalasLucia @Bianco_Lab & team @UChicago model suboptimal thyroid hormone levels during the early stages of cerebral cortex development, revealing an unappreciated role for T4
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Preexisting hypothyroidism in 5,700 patients undergoing bariatric surgery increases the risks of short and long term adverse outcomes. Risks were higher in patients who underwent gastric bypass
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We followed 105 patients before and after developing hypothyroidism (on LT4). Those patients with lower T3 were at risk for dyslipidemia (47.5% vs. 27.3%); even after adjusting for confounders (adjusted OR: 3.6). Monitoring T3 levels should be considered. https://t.co/Ff4BMBPzwW
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Addition of T3 to LT4 therapy may reduce the heightened risks for mortality and #dementia associated with #hypothyroidism. @carvalhalgiulia @Bianco_Lab @mettleson @UFCG_Oficial @UChicagoMed @utmbhealth
https://t.co/b4ogbzwKyW
endocrinologyadvisor.com
LT4 plus L3 therapy vs LT4 therapy alone was associated with reduced mortality and dementia risks among patients with hypothyroidism.
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🚨 New NIH Public Access Policy goes into effect TODAY! Research accepted for publication on July 1, 2025, must be publicly available as soon as it is published. This date was moved up from December 31, 2025, to ensure radical transparency regarding the research NIH supports.
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Treatment of Hypothyroidism that Contains T3 is Associated with Reduced Risk of Dementia and Mortality. Results from 1.26 million patients with hypothyroidism, 126 health organizations across 17 countries.
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This is the data showing increased mortality despite treatment with LT4. To be discussed tomorrow at @ITC2025 .
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Hundreds of surfers watching the sunrise in Copacabana, Rio.
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Over a 20-year follow-up, patients receiving combination therapy (LT4 + T3 or DTE) had a 27% lower risk of dementia and a 31% lower risk of mortality compared to those receiving LT4 alone. Adjusted Cox proportional hazard models confirmed the results.
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This is an impactful study that should reset the approach to the treatment of hypothyroidism. I will show details on Sunday, during the 17th International Thyroid Congress in Rio.
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This is a remarkable testimony of a patient’s journey through hypothyroidism. All should read it and reflect on how providers approach patients with thyroid disease. Kudos to Mary Saunders!
My article was published in Nature review! My struggle to get accurate diagnosis and effective treatment for hypothyroidism:
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Last Thursday I had the pleasure of speaking at Kuma Hospital in Kobe, Japan. Profs. Ito and Akamizu explained that they keep thyroidectomized patients on LT4 and a subnormal TSH to normalize T3 levels and minimize residual symptoms, with very positive results overall.
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Look at these new and exciting findings! Some areas of the brain (e.g., the cerebellum) in LT4-treated mice remain hypothyroid even after TSH levels have normalized. Could this contribute to the brain fog reported by many patients on LT4?
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Comorbid #hypothyroidism was associated with increased #CVD-related health care resource utilization among patients with #diabetes. https://t.co/rkZkUCwLPj
endocrinologyadvisor.com
Hypothyroidism and diabetes were associated with increased cardiovascular disease-related health care resource utilization and increased stroke risk.
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Congrats to Marcelo Ramirez and Matt Ettleson on their paper "The Impact of Hypothyroidism on Cardiovascular-Related Healthcare Utilization in the US Population With Diabetes"
pubmed.ncbi.nlm.nih.gov
HT as a comorbidity with DM was associated with increased healthcare utilization related to CVD, specifically visits associated with stroke/TIA, increased use of specialty care, and greater utiliza...
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