RNA FISH of the periventricular nucleus of the hypothalamus in mouse brain, including cells expressing Crh (green)- these are upstream regulators of cortisol release from adrenal glands and co express a receptor for cortisol (Nr3c1; magenta) and Tubb3 (yellow) #fluorescenceFriday

just hearing from @bhanlon15 about CRF and cortisol in ME/CFS brains prompted me to pin an image of the Crf-expressing neurons to my profile - only to find out I'd already done so. I didn't say it then but the whole reason for this image was to look at CRF in post-acute syndromes

Check out our new review, "The lingering shadow of epidemics: post-acute sequelae across history" by Drs. Christine Miller and @jannamoen. We highlight historical accounts of post-acute infection syndromes (PAIS) through the centuries 👇🏼 #LongCOVID https://t.co/gCS7nmVKUW

I like this guy's threads, but they're a little bit like a sentence in German: you have to go all the way to the end to get to the action, i.e., the link to the original paper

Scientists have an obligation to do better. This lack of rigor will provide ammo for the entire anti-science establishment. Editors, reviewers, authors, and entire journal staff should be ashamed

When some people accuse others, being guilty of the same offenses is not uncommon. This guy said he got addicted to kratom, so then all the neutraceutical folks accused him of being a shill for pharma. But who are the shills really? https://t.co/ISN87hLzWP

When I first met with RFK Jr. for this story, he told me his staff thought it was a bad idea. A few months later, he accused me of being a scorpion who had tricked him. But we kept talking.

Lol "hot dog looking" Whenever I see a corn dog all I can think is that it looks like a cattail from my childhood swamp

There's symptom endophenotypes but gets even more interesting when we layer the biomarker data on top of the patient reports. There will likely be types of LC driven by auto antibodies and those driven by persistent virus, among other drivers

This essential truth applies to vaccine debates, political issues, and public trust of scientists: facts only helps humans justify the choice they are already making. To persuade anyone you must appeal to personal safety and identity first. https://t.co/uIH4VNt1hz

Fascinating for multiple reasons: it shows how patients can finally feel validated after being dismissed by medical establishment, and how trials can incur costs for non-medical supplies. Seeing the drug class here makes the packaging less surprising, though

Importantly, Kidd et al. IMPROVED the field and led to real genetic causes of autism or psychiatric disorders. But there are certainly environmental causes of childhood psychiatric disorders too. So the goal (hopefully) is not to necessarily disprove, but instead to IMPROVE 4/4

Some disagree: one of my mentors warned against spending too much effort to disprove flawed assertions. Gotta light a candle, perhaps. Kidd not only cleaned up the literature but made seminal contributions (importance of considering diversity in genetic studies, ironically) 3/

It's common for a field to develop "trendy" topics (I'm old enough to remember nNOS) and also trendy to tear down trendy topics. Such criticism is still important (e.g. Ken Kidd helped a lot by removing spurious genetic association studies in psychiatric disease) 2/

I've been a fan of @WiringTheBrain for many years and notice that he spent a lot of time criticizing epigenetics and now he's laying into gut-brain axis. 🧵 1/

Never thought I'd see an ad on FB for NIH Institute Director

Stanford Medicine investigators and their colleagues have found that one of humanity’s most ubiquitous infectious pathogens bears the blame for lupus, the chronic autoimmune condition. https://t.co/bqFmVLYT3h

The aspect of science education that has been lax has been presentation of science as "laws" to "believe" in, rather than a process that sometimes produces wrong guesses but always re-evaluates positions in the face of new evidence. But who presented it that way? Not scientists.

I guess these kind of takes are useful, but what have scientists done "wrong" exactly? I've participated in public outreach events and education for my entire career. I've never known any "silent" scientist - they were everywhere during pandemic /1

Great platform you've built here, Elon

Latest example of a broken clock being right twice per day. Young people have been really crushed by our system, but it's not because of student debt. It is due to zoning regs and legislation that made a massive wealth transfer to older age groups via tax cuts etc.