Christopher A. Baker
@bakermind
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Firstgen in Yale Center for Infection & Immunity using imaging technologies to study pain in long COVID and similar syndromes. https://t.co/Dhf7B783IT
JP➡️TX➡️PI➡️OH➡️CT➡️FL➡️WA➡️CT
Joined October 2012
People consider the pineal gland to be a Third Eye. Maybe they should have focused on the Subfornical Organ instead - also in the middle of the brain, but with a newly acknowledged pathway for T cell traffic between the gut and the brain that affects behavior #FluorescenceFriday
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I've always been circumspect about gabapentin. It seems like a knee jerk script for a lot of neurologists.
rapm.bmj.com
Introduction Gabapentin is widely used to treat chronic pain, but its association with cognitive decline and dementia remains unclear. This study examined whether gabapentin prescription is associa...
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Grok ain't doing so great.
@patricksp71 @SenAdamSchiff Yes, SenAdamSchiff appears to be a parody account. The official account for Senator Adam Schiff is AdamSchiff, as confirmed by his Senate website and reliable sources. The bio lacks any parody disclaimer, but posts often exaggerate for satirical effect.
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I'm not a clinician, but gabapentin always seemed like a cop out to me - like throwing anything at all at a patient to see what sticks. What's the harm? Apparently there may indeed be some harm.
Regular gabapentin use appeared to increase risk of dementia by 29% and mild cognitive impairment by 85%.
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I know @JDVance is old enough to remember this. I'm guessing he liked it then .
www.youtube.com
In September 2001, Texas ad agency GSD&M created a PSA to celebrate the country's extraordinary diversity and remind Americans that it was the time to unite ...
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RT @acrossthemersey: Country music star Trisha Yearwood says a mild infection caused her to struggle with LongCOVID brain fog so much that….
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RT @Brain_VTA: ‼️News︱Neuron.👏👏Prof. Yousheng Shu 's team discovered the pathogenic mechanism of the autism high-risk gene SCN2A and propos….
www.cell.com
SCN2A loss-of-function mutations are a high-risk factor for autism. Li et al. show that selective Scn2a deficiency in VTA dopaminergic neurons or global haploinsufficiency in Scn2a+/− mice causes...
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RT @BIONIC_Lab: NIH’s 2025 policy on animal testing grants worries neuroscientists. Organoids & in silico models can’t yet replicate glymph….
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found my new favorite workout.
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Does this seem like it will end biology research on most campuses that don't have easy access to IRBs and major medical centers with human subjects.
Join us at 10 a.m. ET for a workshop with @US_FDA on how we can work together to reduce animal testing in research. Tune in to the livestream ➡️
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This paper is suggestive but not conclusive - it shows that dumping spike protein on human retina cultures induces beta amyloid that colocalizes with spike, and that similar colocalization is detected in postmortem retina from COVID patients. Very thought-provoking nevertheless.
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intersection of SARS-CoV-2 and beta amyloid gets at concepts that have bugged me for years: 1) that amyloid deposition is an antecedent of infection or host defense, and 2) that spike protein itself may have amyloidogenic properties.
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Ever since I was a grad student I've heard whispers of this hypothesis that protein aggregation is part of host defense. It has manifest in the discovery of the inflammasome and beyond:.
Nature research paper: Functional amyloid proteins confer defence against predatory bacteria.
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Seems like employees at @HHSGov.and @NIH no longer get to read @Nature journals with a work subscription.
www.medpagetoday.com
Move comes as top medical journals have been scrutinized by Trump administration officials
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This trajectory reminds me of another trajectory, one that eventually became associated with stuffed tortillas.
Credit where credit is due. @realDonaldTrump has successfully resolved several serious conflicts around the world.
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Not bad, assuming the NIH grant will cover the costs of open access publication.
Researchers funded by the NIH will be required to make their scientific papers available to read for free as soon as they are published.
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new pathway discovered by Tomomi Yoshida, Andrew Wang, and tons of other great @Yale folks, described in this recent report @Nature
www.nature.com
Nature - A distinct population of CD4 T cells resides in specific regions of the steady-state brain, and these T cells are programmed in the periphery by the microbiome to coordinate adaptive...
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above we see the Subfornical Organ dangling into the 3rd ventricle of the brain, flanked by choroid plexus cells making cerebrospinal fluid. Cell nuclei in blue, with in situ hybridization for genes marking macrophage subsets: F13a1 (yellow), Cx3cr1 (magenta), and Aif1 (cyan).
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