Alex Xiong
@axiong_x
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Very proud to participate in this study by doing the enzyme kinetics and X-ray crytallogtaphy! Very effective drug without the ritonavir, used by my mum, my wife and myself.
OUT NOW 👉Preclinical evaluation of the SARS-CoV-2 Mpro inhibitor RAY1216 with improved pharmakokinetics compared to nirmatrelvir.
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New oral antiviral drug to be used for treatment of COVID-19 .and we have a preprint on this drug - RAY1216."Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitor" #bioRxiv.
chinadaily.com.cn
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I hope the stabilised spike we found in this research will help for COVID-19 vaccine development and tests. Thanks again for all the people involved in the study a true team effort! @BriggsGroup @igoodfel @ZunlongKe @MRC_LMB @SjorsScheres @Carter_Lab
nature.com
Nature Structural & Molecular Biology - The SARS-CoV-2 spike glycoprotein is flexible, and its receptor-binding domain (RBD) fluctuates between open and closed conformations. Disulfide bonds...
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Finally know what he has been doing late at night on Krios!👍.
Which PI purifies the protein, collects the cryo-EM data, and processes the images, all by oneself? Nigel Unwin has been doing this in the past 45 years! He just published another single-author research article.
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Great work on classifications.
@SjorsScheres @BriggsGroup Also proud to to work on this #SARSCoV2 S protein analysis using #CryoEM subtomo avg with #Relion. Thanks everybody @BriggsGroup @SjorsScheres @ZunlongKe @biochem_fan @axiong_x @MRC_LMB.
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Very thorough characterisation of S protein on SARS-CoV-2 virion surface, very proud to have played a small part in this study.@ZunlongKe.@MRC_LMB @BriggsGroup.@SjorsScheres @biochem_fan
biorxiv.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virions are surrounded by a lipid bilayer from which spike (S) protein trimers protrude. Heavily glycosylated S trimers bind the ACE2...
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Proud to play a small part in this study, it shows again how fragile these spike proteins are. And their distribution is sparse, these properties are very different from flu virus and have implications for vaccine @ZunlongKe @MRC_LMB @BriggsGroup @SjorsScheres @biochem_fan.
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I am very glad I have helped the hospitals in Cambridge to diagnose COVID-19 by providing SARS-CoV-2 spike proteins using fantastic protein production infrastructure of MRC-LMB. @MRC_LMB @BriggsGroup
medrxiv.org
Background Rapid COVID-19 diagnosis in hospital is essential for patient management and identification of infectious patients to limit the potential for nosocomial transmission. The diagnosis of...
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I would like also to thank everyone who helped me in @MRC_LMB and especially Takanori @biochem_fan @SjorsScheres and Kun who is Not on Twitter who gave me a lot of suggestions on helical reconstruction!.
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I am very proud of this work!.
There are other viruses with pandemic potential. @jpeukes, @axiong_x and others have collaborated to determine the native structure of M1, the most abundant protein in influenza virions. @MRC_LMB @embl @SimonErlendsson @williamnwan @CiidHeidelberg.
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Great tomography work, it is satisfying when our structures coming together for a crystal clear view of flu virus assembly!.
Happy to share our work on the influenza matrix protein M1 - part of my PhD work with @BriggsGroup Great collaboration with @axiong_x. Thanks to everyone involved.
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Fine details of flu virus assembly and disassembly. A decade old question answered. 7 years of my time, a personal journey from Mill Hill to Seattle to Cambridge, thanks to everyone who helped me! @TheCrick @veeslerlab @BriggsGroup
biorxiv.org
Influenza A virus causes millions of severe illnesses during annual epidemics. The most abundant protein in influenza virions is the matrix protein M1 that mediates virus assembly by forming an...
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Very nice calculation.
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This is great work!.
At the Options X Influenza conference in Singapore on 1st Sept I will give a talk on H17 Influenza. This is a real honour! @Medway_Pharmacy @ViralPseudotype
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Arh, it has been like this for years then!.
"Three-dimensional coordinates from stereodiagrams of molecular structures" (Acta Cryst., 1980).In 80s, deposition of atomic coordinates was not mandatory and many were hidden. So Rossmann wrote a program to get 3D coordinates from stereograms in papers!.
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I am missing the Veesler lab outing!.
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It has been great pleasure to work with you! Looking forward to seeing you again soon!.
It is one of the greatest honors to get to do a sabbatical in someone else’s lab - to be a student again and do things with your own hands. Thank you John Briggs, Alex @ZunlongKe @DustinMorado and the talented @BriggsGroup for a valuable & meaningful summer. See you again soon!.
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RT @NatureRevMicro: Therapeutic strategies to target the Ebola virus life cycle. Hoenen, Groseth and Feldmann address strategies that have….
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