Aurélien Dinh
@aurdinh
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Antibiotic prophylaxis approaches for urinary tract infections. - PubMed - NCBI
pubmed.ncbi.nlm.nih.gov
Antibiotic prophylaxis approaches for urinary tract infections
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🆕⚡🦴Silent But Sneaky: Culture-Negative PJIs Uncovered, JBJI, 2025 🚀 What they did: 🔬 Retrospective multi-center study across 🇦🇺 Australia, 🇳🇱 Netherlands & 🇺🇸 USA 📊 563 PJI cases analyzed (470 culture-positive, 93 culture-negative) 👩⚕️ Collected patient demographics,
jbji.copernicus.org
Abstract. Background: Culture-negative periprosthetic joint infections (CN-PJIs) remain a major problem in the field of orthopedic infections. The clinical features of CN-PJI and its risk factors...
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In the SONIA trial conducted in general medical wards with limited diagnostic and therapeutic resources in Kenya, glucocorticoids reduced mortality in patients with community-acquired pneumonia. Full trial results and Research Summary: https://t.co/WEQvqhbqKY
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🆕⚡🦠 Cefiderocol Mono vs Combo, No Difference in Survival — Hits MDR Pseudo/ACB/Steno, Misses NDM Again — Game Over | IJID, 2025 🚀 What they did 🏥 Multicentre, retrospective study across Italy; real-world use of cefiderocol (CFD) for MDR GNBIs. 💊 Assessed mono vs combo
ijidonline.com
Cefiderocol is a novel siderophore cephalosporin approved in 2019 by the US Food and Drug Administration (FDA) for the treatment of hospital-acquired pneumonia, ventilator-associated pneumonia, and...
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"Finally, the classically recommended ‘four-to-six-week’ regimen of either fluoroquinolones or TMP-SMX is not based on solid evidence, as we found no studies directly assessing five or six weeks of these antibiotics. Only fosfomycin was studied for durations over four weeks;
🆕⚡🧬 How Long Is Long Enough? — CBP Antibiotic Durations Still Built on Sand | CMI Communications, 2025 🚀 Methods 📚 Systematic Review of global literature (1946–2025) on ABx durations for chronic bacterial prostatitis (CBP). 🧪 Included RCTs + Obs cohorts; outcomes =
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🆕⚡🦠 Aztreonam-Avibactam — The Undisputed Hero 🏆 Tackling MBLs Like a Pro| AAC/2025 🐯 Tigecycline — “The Tiger,” still strong and reliable but not in BSI. 🐴 Cefiderocol — Once the Trojan Horse, but not the soldier we hoped for 🎯 Cefepime-Taniborbactam — Targets MBLs, yet
journals.asm.org
Acquired metallo-β-lactamases (MBLs) emerged in the early 1990s with the description of IMP-1 in a Serratia marcescens isolate from Japan (1). The description of this enzyme was followed by the...
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🆕⚡🔥🦟 Toward a Dengue Pill — First Real Signal of Antiviral Prophylaxis for Dengue, NEJM, 2025 🚀 What they did 🧪 Phase 2a, double-blind, randomized trial in healthy adults 💊 Tested daily mosnodenvir (low, medium, high dose) vs placebo 🦟 Used a controlled human infection
nejm.org
Approximately half the worldwide population is at risk for dengue. No antiviral prophylaxis or treatment options are available. In a phase 2a, double-blind, randomized trial, we assigned healthy ad...
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Short course of antimicrobial treatment for uncomplicated enterococcal bacteremia 🔺Shorter is better https://t.co/j7rBLXGHVn
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🆕💫Impact of discontinuation of contact precautions on healthcare-associated ESBL-producing Escherichia coli in a large tertiary care hospital: an interrupted time-series analysis #IDXposts
academic.oup.com
Abstract. At Geneva University Hospitals, contact precautions for ESBL-producing Escherichia coli were discontinued in 2019. Among 2336 hospital-associated
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Strong language in this editorial from the American Academy of Ophthalmology about the AAO position paper that recommended against routine screening of patients for endophthalmitis caused by Candida septicemia #IDTwitter #MedEd #medtwitter #TwitteRx
https://t.co/QVVTBHi8n8
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🆕💫Achilles’ heel of the Trojan Horse? A systematic evaluation of cefiderocol susceptibility testing #IDXposts
academic.oup.com
Abstract. Cefiderocol, an innovative siderophore cephalosporin, presents a novel therapeutic option against a spectrum of multidrug-resistant (MDR) Gram-ne
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Everyone who's treating MRSA Bacteremia should read this article now! An excellent review by @VanceFowler5 et Al @CIDJournal Persistent MRSA Bacteremia: Resetting the Clock for Optimal Management 🌟Excellent figures 🌟 @snap_trial Thoughts 🤔 #IDTwitter
https://t.co/9A9drvhWbF
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Antibiotics are the cornerstone of community-acquired pneumonia treatment, but the roles of adjunctive therapies, including corticosteroids and immunomodulators, remain incompletely defined. #IDXposts Steroids 🔥 topic sCAP
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🆕💫 Meta-analysis: tedizolid vs linezolid in ABSSSIs ✅ Lower risk of thrombocytopenia (RR 0.60), neutropenia (RR 0.35) & GI issues (RR 0.69) ✅ Once-daily dosing, non-inferior efficacy, safer. Could tedizolid be a more attractive alternative? Thoughts! https://t.co/MMw5ZPIznV
clinicalmicrobiologyandinfection.org
Acute bacterial skin and skin-structure infections (ABSSSIs) are usually caused by gram-positive pathogens, particularly Staphylococcus aureus. Tedizolid, which belongs to the oxazolidinone family,...
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Excellent paper provides a comprehensive review of the complexities of antifungal treatment strategies, dosing regimens and administration route 🆕💫Antifungal treatment strategies and their impact on resistance development in clinical settings #IDXposts
academic.oup.com
Abstract. Invasive fungal diseases, particularly among immunocompromised patients, represent a growing clinical challenge due to limited therapeutic option
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Syphilis is an infectious disease caused by Treponema pallidum, a gram-negative spirochete bacterium. This Review summarizes the epidemiology, diagnosis, treatment, and prevention of #syphilis. 🧵 https://t.co/6XGQMiA08p
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🔥Just published The GAME CHANGER RCT Among patients with a hospital-acquired or health-care-associated Gram-negative bloodstream infection, cefiderocol resulted in non-inferior but not superior 14-day mortality compared with standard of care #IDXposts
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Original Article: Randomized Trial of Targeted Indoor Spraying to Prevent Aedes-Borne Diseases https://t.co/02ducJcAlZ
#IDTwitter #GlobalHealth
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🆕💫Efficacy of cefiderocol in combination with xeruborbactam versus taniborbactam against cefiderocol-R NDM-producing Pseudomonas aeruginosa Taniborbactam restored cefiderocol susceptibility in most isolates(20/21, 95.2%),while xeruborbactam had no effect https://t.co/QTp9gMPoIJ
journals.asm.org
Metallo-beta-lactamase (MBL)-producing gram-negative bacteria, particularly those expressing NDM, present a major clinical challenge due to the limited availability of alternative treatment options....
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Shorter durations of #antibiotic prophylaxis, including no prophylaxis, appear noninferior to longer durations for preventing mortality in patients with #cirrhosis and upper gastrointestinal bleeding. https://t.co/DB9lgIbHBm
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