Andrew Cooper
@AndrewCooperajr
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Image credits: thanks to Elizabeth Fischer, Ababacar Diouf and Alan Hoofring for helping me generate beautiful SEM images of malaria parasites invading red blood cells! 3/12
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🚨 Reminder: Pop-Up Gaeltacht is Tomorrow! ☘️🗣️ Come speak (or listen to!) a bit of Gaeilge in a fun + friendly setting. All levels welcome! 📅 Date: Thursday, April 10 - Tomorrow 📍 Location: @ExilesBarDC (upstairs) ⏰ Time: 6:30 - 8:30 PM
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☘️🗣️ Bígí Linn! IN-DC is thrilled co-host our first Pop-Up Gaeltacht. No matter your level of Irish, you're welcome to join in for great conversation, community and a bit of craic. Come for the language, stay for the connections! 📆April 10 ⏰6:30 - 8:30 PM 📍@ExilesBarDC
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‼️New paper alert‼️ Our review exploring the ageing immune response in disease and the potential of the Nrf2-HO-1 axis as a therapeutic target is now available online at @FrontImmunol
#irishresearch #ageing #immunology
frontiersin.org
Nrf-2 is a master transcriptional regulator of a number of genes involved in the adaptive response to oxidative stress. Among the genes upregulated by Nrf2, ...
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Join us this Friday for #EuropeanResearchersNight in @tcdTBSI and learn how to train your immune system to beat the bugs! Even try your own hand as a part of our pest patrol team to see how well you can defend yourself against bug invasion!🦠🧬🦠 #startatern #irishresearch
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Very excited for this! Welcome to anyone interested in learning more about our immune system's built in pest patrol! (Disclaimer: those uninterested are welcome also, perhaps we can inspire you 🧑🔬🧑🔬🧑🔬)
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Image credits: thanks to Elizabeth Fischer, Ababacar Diouf and Alan Hoofring for helping me generate beautiful SEM images of malaria parasites invading red blood cells! 3/12
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Final congratulations to everyone involved, especially pioneers of the field Joshua Tan, @parasitematt and @S1monJDraper. https://t.co/TSEYlWG6di 12/12
cell.com
An in-depth analysis of the naturally acquired antibody response to the malaria vaccine candidate RH5 reveals that infection can induce rare but potently neutralizing antibodies that target the same...
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Our findings show infection can elicit potent antibodies similar to those from vaccination, encouraging hopes that malaria infection of vaccinees can boost vaccine-based immunity. 11/12
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With the first RH5 vaccine now undergoing clinical trials, it’s crucial to know how vaccination will interact with effects of natural infection. 10/12
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Also in this issue, Jordan Barrett, Kirsty McHugh, @S1monJDraper and co dive deep on the antigenic landscape of RH5. Go read! https://t.co/OrQp3Pn1eZ 9/12
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Moreover, the best infection-derived and vaccination-derived antibodies have similar or even identical genetic backgrounds, and structural work shows they bind RH5 in precisely the same places, showing how infection and vaccination lead to convergent antibody development. 8/12
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While the best RH5 antibodies target the 'top' of RH5, where it docks with the red blood cell, most naturally-induced RH5 antibodies target the 'bottom' of the molecule. But some infection-derived RH5 antibodies were exceptional in this regard - top-binders, and potent too! 7/12
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Our study found that natural infection raises transient RH5 antibody titres, but the resulting monoclonal antibodies can be strikingly potent, performing similarly to the best antibodies from RH5 vaccination. 6/12
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We isolated almost 200 RH5 antibodies from cohorts of vaccinated volunteers and naturally-infected volunteers. With this large collection we were able to do some deep analysis on antibody responses to this antigen. 5/12
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Our study focused on the human antibody response to malaria, particularly to the antigen RH5, which is a bottleneck for blood stage infection. Malaria parasites employ RH5 as part of their process of invading red blood cells. Block RH5, block the parasite. 4/12
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Delighted that we have been selected as the cover story(ies) for the current issue of Cell! Thanks to @CellCellPress for selecting us and to everyone for your hard work on this, especially co-authors @Lawreate7 and @brendanfarrell. https://t.co/M3I829eBNZ 1/12
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Introducing ‘Pint of Immunology’🍻 Join us Sept 2nd for a night of #immunology & pints for a European Congress of Immunology 2024 public outreach event! Open to all- get your free but limited tickets now https://t.co/AvMRyd82x7 Please RT and share! @Irishimmunology @tcdTBSI
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