How can we predict treatment response in #MultipleSclerosis before starting therapy?.In our latest study in @EANeurology , we identified a genetic variant in NFKB linked to response to interferon-β. 🧬Just one small step toward making personalized medicine a reality. #MSresearch

RT @MSJ_Research: 🔊 Listen to @andreuvilaseca7 @AVidalJordana @XMontalban @cemcat_em on how we could accurately diagnose a subclinical peri….

📢 New clue in the pain puzzle: FGFR3 antibodies don’t just mark sensory neuronopathy with neuropathic pain, they cause it!.By triggering hyperexcitability in nociceptive neurons, they drive pain sensitivity. Could this be just the tip of the iceberg in autoimmune pain disorders?

🟢📢Towards unified MS diagnostic criteria!.This study shows McDonald’s dissemination-in-space criteria already work well at RIS baseline—and baseline CELs boost specificity a lot!. 🔜Another key step toward the 2024 McDonald criteria update coming up soon! #MS #Neurology

👫Human data backs the animal model! This multicenter study shows single-course anti-CD20 reduces relapses in anti-NMDAR encephalitis, though time to immunotherapy may confound. Just like the model, the biggest impact is transient (first 12 months post-infusion) #Neuro

🟢Major advance in anti-NMDAR encephalitis in 2025H1!🔝.An animal model shows a more complete clinical syndrome (even stereotypes) and brain histopathological dynamics. 💉When Rituximab is added, depletes B cells and symptoms improve. But when B cells return…so do the symptoms!

RT @EoinFlanagan14: Delighted to share Dinoto et al study on late onset MOGAD (50 yrs or more) ➡️ Accounts for 25% of MOGAD ➡️ Optic neurit….

Are NfLs just biomarkers, or active drivers of damage?.This fascinating study in @CellCellPress shows that NfL release can trigger microglial inflammatory activation (and worse outcomes), a process that was blocked by anti-NfL antibodies!.Thanks @SamanthaBanksMD for the heads-up!

Clinical trials in #AutoimmuneEncephalitis are ongoing!.Basket trial designs help tackle rarity & heterogeneity, but paraneoplastic cases still lack representation. Let’s send patients to recruiting centers, share clinical responsibility with referring clinicians’ voices heard!

Could a simple lymph node fine-needle aspiration become the next big diagnostic tool in #Neuroimmunology after CSF analysis?.This study shows it’s possible to detect key proteins and gene expression with just this easy procedure!.Read more👇👇

PS: If Karl Popper had seen the unexpected findings included in the aims of the study…🫣.

More evidence that in LGI1/CASPR2 #encephalitis, Bcell hypermutation (mostly in plasmablasts) to boost antigen affinity happens in the periphery.Central memory T cells likely interact with Bcells in nearby lymph nodes.Still wrapping my head around the invariant T cell data tho!😂

Ever wondered about the deepest questions in neurophysiology you never got answers to?.At @MayoClinic, we are lucky to attend an incredible course led by Prof. Benarroch, a true masterclass in understanding the nervous system like never before🥇.@MayoClinicNeuro @MayoNeuroFellow

Interferonopathies, with Aicardi-Goutières syndrome as a paradigm, should be on the radar in autoimmune neurology💡.This @CellCellPress study shows CNS-driven IFN production in CNS-predominant cases, with endothelial cells mediating vasculopathy via the IFN receptor!.#Neurology

RT @Mayo_AING: Reminder to all interested in #autoimmune #neurology. Please join us. For great weather, faculty tal….

Beyond being a remarkable study on molecular mapping in MS, this manuscript tells a fascinating story of lesions, white matter, and gene expression!.All key players are here: CD45, HLA, MMP2, Myelin…Just waiting for B cells & Epstein-Barr Virus to join the party🔥#MS #Neurology

Could Regulatory T cells revolutionize autoimmune disease the way CAR-T cells have transformed cancer therapy?🤔👇🏽.This fascinating @GreenJournal study suggests that while thymic Tregs are affected in MS, other regs compensate, until inflammation tips the balance! #Neurology

Susac Syndrome remains underdiagnosed!👀.In this podcast, we dive into key clues for recognition & treatment in a relaxed, insightful chat.An absolute pleasure to learn from Prfs. Ilka Kleffner & Barbara Willekens, don’t miss it!👇 #Neurology @EANeurology.

MS lacks a specific diagnostic biomarker, so considering alternative diagnoses is crucial,especially in high-risk patients!🤯.In CIS patients from @cemcat_em, we highlight these alternative diagnosis and the high specificity of MS criteria even here!✅.#MultipleSclerosis &Beyond

RT @EoinFlanagan14: Delighted to share Kwon & @NanthayaTisa et al study with our Korean colleagues led by Dr Sung-Min Kim ➡️ We found para….