amosliang
@amosliang2
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Principal investigator at MRC PPU, UoDundee. Probably has an unhealthy fascination on how cells digest themselves during stress (he/him 🇲🇾 🏳️🌈)
Joined June 2015
So excited to start the next chapter of my career at the MRC PPU. I look forward to working alongside and collaborate with the amazing groups at the unit!
Delighted to welcome Jin Rui (Amos) Liang as our newest MRC PPU principal investigator https://t.co/tZZJHQiTiO
@amosliang2 @UoDLifeSciences #ERphagy
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Registration for the joint Autophagy UK & Proteostasis UK meeting is now open. Going to be a great meeting and we look forward to welcoming you to Dundee!
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Very interesting discovery and a super neat reporter system to study peroxisome import! Congrats @brookemeghan & @richardson_lab
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The second joint Christmas dinner between the Liang and Swatek labs. Both of our labs have come a long way since the first year! Grateful for everyone that takes a leap of faith in joining our labs.
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Check out this exciting work coming out of @jcornlab & @bode_lab! Well done @matthias_muhar & @jakobfarnung!
Cells degrade unfolded proteins. But do they also check for chemical damage? We found that a C-terminal amide is completely sufficient for degradation by an SCF/FBXO31 ligase complex! With @bode_lab @matthias_muhar @jakobfarnung. https://t.co/Wtidapo1VT 🧵
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Cells degrade unfolded proteins. But do they also check for chemical damage? We found that a C-terminal amide is completely sufficient for degradation by an SCF/FBXO31 ligase complex! With @bode_lab @matthias_muhar @jakobfarnung. https://t.co/Wtidapo1VT 🧵
biorxiv.org
During normal cellular homeostasis unfolded and mis-localized proteins are recognized and removed, preventing the build-up of toxic byproducts[1][1]. When protein homeostasis is perturbed during...
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Hey everyone! We are the DundeeTrackers (4 PI's from @UoDLifeSciences) and we are taking part in the Edinburgh Marathon Relay Race to raise money for @CR_UK @CRUKScotland this Sunday! There is still time to make a small donation if you can! https://t.co/DdwgtTG2PJ
justgiving.com
Help TheDundeeTrackers Team raise money to support Cancer Research UK
A team of Dundee researchers will run @edinmarathon Relay to engage runners with their unique lab coat, with "I study cancer, ask me about my research" written on it, to promote their research and raise funds for @CR_UK @KasperR64099310
https://t.co/akfFJBeErC
#emf2023
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Pleased to see our new study on #Parkin activation - thanks to Michael Stevens and @OdettaAntico @mrcppu and great collaboration with @jftrempe, Ted Fon @TheNeuro_MNI and Wolf Springer @MayoClinic #teamscience
Survey of synthetic mutations in the Parkin E3 ubiquitin ligase suggests hot spots for the design of activators that can rescue its function. @jftrempe @CRBSMcGill @miratul_neuro @TheNeuro_MNI
https://t.co/yO8NRhBzVd
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with the potential to learn/apply CRISPR-based screening. Please directly email me for more information on both positions! #cruk #postdoc #autophagy #hiring #cancer #postdocposition @mrcppu @UoDLifeSciences (2/2)
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My lab is hiring a CRUK-funded postdoc to work on ERphagy in cancer progression! https://t.co/nq2ELOBHWR We are looking for candidates with cancer/cell biology expertise. There is also another upcoming postdoc position to work more broadly on other aspects of ER QC (1/2)
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Postdoctoral Research Fellow position available in Liang lab: https://t.co/GjfB2v0hNV
#Autophagy #ERphagy #CRUK #CRISPR #cancerbiology #cellbiology @amosliang2
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I'm SO EXCITED to share our new pre-print! 🥳 You finally got your RNA-seq data. You open RStudio, stare at the screen for 5 mins...And realize you don't even remember how to import a table. How will you analyze your data?!😱We're here to help! A 🧵👇(1/9)
biorxiv.org
Background Amongst the major challenges in next-generation sequencing experiments are exploratory data analysis, interpreting trends, identifying potential targets/candidates, and visualizing the...
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#FanconiAnemia causes devastating bone marrow failure. But #CRISPR HDR editing doesn't work in cells from these patients. In collaboration w/ @PauFerrol & funding @EJPRareDiseases we develop a #BaseEditing approach for bone marrow cells from FA patients.
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Excited to reveal an essential function for protein degradation and quality control in development: shaping network dynamics to control gene expression and cell identity! Many implications for #TPD. A little thread. https://t.co/50qOFA0bsl
biorxiv.org
All eukaryotes require intricate protein networks to translate developmental signals into accurate cell fate decisions. Mutations that disturb crucial interactions between network components often...
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This #preprint finds a cryptic LIR used to coordinate #LC3 lipidation for #autophagy and spans all kinds of fun techniques. It's also just one of many super collaborations between @bode_lab and my group. Much more to come! @jakobfarnung @amosliang2 @matthias_muhar
We love it when group members do projects we never expected to be working on...autophagy, protein-structures, CRISPR knockouts. Great work by @jakobfarnung and our collaborators @jcornlab
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I'm in Dundee at last! I'm also interviewing postdocs to explore the roles of ERphagy. https://t.co/n2JSDPRw8o Deadline approaching soon!
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Check out our latest review summarizing various techniques & contributions of CRISPR-based screens on autophagy discoveries! We also discuss recent screening tech dev that can improve our understanding of autophagy in various contexts! #autophagy #CRISPR @jcornlab
A CRISPR view on autophagy
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We talk to three new group leaders focusing on different aspects of quality control about their research and the process of setting up their labs: Chantell Evans @channyskye @evanslab, Jin Rui (Amos) Liang @amosliang2 @mrcppu, and Cristina Mayor-Ruiz…
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Extremely honoured to be awarded the @CR_UK Career Development Fellowship to study the impact of ER-phagy on cancer progression. I will be hiring postdocs and recruiting students soon at the @mrcppu. Please stay tuned! #autophagy #CancerResearch #erphagy #crispr @CRUKresearch
Jin Rui (Amos) Liang awarded prestigious CRUK Career Development Fellowship https://t.co/Nz18ROFHQi
#autophagy #ERphagy #cancer #CRISPR @amosliang2
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