Adam Auton
@adamauton
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In the latest edition of "Huh, I didn't expect that to work", our latest paper shows that LLMs can outperform existing methods for identifying causal genes in genome-wide association studies. š§µ.
medrxiv.org
Identifying underlying causal genes at significant loci from genome-wide association studies (GWAS) remains a challenging task. Literature evidence for disease-gene co-occurrence, whether through...
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The brilliant Sarah Senk, together with Taiyo Inoue, has just launched a podcast that explores the implications of AI for higher education: My Robot Teacher. Please give it a listen! #MyRobotTeacher #HigherEd
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Yesterday was a hard day at 23andMe, and we said goodbye to a number of tremendously talented colleagues. If people have job openings in the genetics space that they'd like me to share with the impacted folks, please do post here.
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RT @MariosGeorgakis: Human genetics informs drug developmentš§¬š. šGDF15 is a potential target for hyperemesis gravidarum. BUT fetal & maternā¦.
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RT @annewoj23: Thank you to our customers and the @23andMeResearch team for this work on the genetics of #longcovid.
medrxiv.org
The etiology of Long COVID is poorly understood despite its estimated global burden of 65 million cases. There exists a paucity of genetic studies that can shed light on potential mechanisms leading...
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RT @EricTopol: This week in key Covid publications and preprints:.āIncreased risk of major adverse cardiovascular events 3-years out, irresā¦.
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RT @ninaadsc: šPublication alert: In a preprint from the @23andMeResearch team, we conducted one of the largest GWAS study of Long COVID anā¦.
medrxiv.org
The etiology of Long COVID is poorly understood despite its estimated global burden of 65 million cases. There exists a paucity of genetic studies that can shed light on potential mechanisms leading...
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RT @VirusesImmunity: Much-needed data on the genetics of #longCOVID in a new preprint by @23andMeResearch - GWAS of #LongCOVID identifiedā¦.
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RT @23andMeResearch: We're looking for a scientific lead for our long standing (15 years!) Parkinson's disease research program. The prograā¦.
23andme.com
Read about our mission-based culture, look up open positions and check out the perks of working here.
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RT @EadaoinSays: It is āthe next thing in the field of ancient DNAā, says Ćadaoin Harney, a population geneticist at consumer-genetics firmā¦.
nature.com
Nature - Scientists are using consumer-genomics databases to link living people to ancestors from the recent and not-so-recent past. But the meaning of these connections isnāt always clear.
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Delighted to see this out. What can the 23andMe database tell us about Lp(a)? The indefatigable @mvholmes walks us through it!.
In a preprint from the @23andMeResearch team, we used Mendelian randomization to explore the genetically-predicted causal effects of Lp(a) on a range (n=489) of human traits and diseases.
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We're looking for a Senior Bioinformatician to join our team, working to make uncovering novel genetic insights faster, easier, and more enjoyable!. Please consider sharing:
23andme.com
Read about our mission-based culture, look up open positions and check out the perks of working here.
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After >4 years, Iāve finally caught Covid. š Thankfully seems to be a mild case so far. But Iāve lost my sense of smell - such a strange experience! Reminds me of our paper from a couple of years ago. š¦ š§¬ .
nature.com
Nature Genetics - Multi-ancestry genome-wide analyses identify variants near UGT2A1 and UGT2A2 associated with COVID-19-related loss of smell or taste. Both genes are expressed in the olfactory...
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RT @doctorveera: A weekend read for you with more of my thoughts on the recent discussion on the value of human genetics in predicting drugā¦.
gwasstories.com
Growing evidence that human genetics can double or even triple drug development success rates
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RT @doctorveera: Many of you might be aware of the commonly quoted success rate of ~10% in drug development. One of the efficient ways to rā¦.
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RT @nmancuso_: Nice work from 23andMe researchers further supporting that drug targets with genetic support are more likely to have a cliniā¦.
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RT @mgeorgakis1: Analyses on 7.5M individuals from @23andMe confirm that drugs with genetic support are more likely to survive clinical devā¦.
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Thereās still a massive amount of value left to be had in utilizing genetics for target discovery; weāre still just scratching the surface. A nice thread on our latest preprint, showing that more scale = more useful target insights. Comments welcome!š.
Previous papers have shown that drug targets with supporting genetic evidence can have twice the success rate when reaching clinical trials. In our most recent paper (, we looked at how data from @23andMe can provide additional genetic evidence. š§µ1/8.
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RT @StevenSalzberg1: The human chromosomes are numbered incorrectly (The fourth in an irregular series of threads about #Bioinformatics.) Aā¦.
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RT @23andMe: A new genome-wide association study of coffee intake in US-based 23andMe participants explores the relationships of coffee intā¦.
nature.com
Neuropsychopharmacology - Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations
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RT @doctorveera: Fascinating analysis of the ancestral origin and dispersion of Parkinson's disease-associated LRRK2 G2019S variant in 23anā¦.
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