Check out our latest preprint on heart assembloids (second in a month!) We developed a method to integrate heart organoids with cardiac neural crest (NC) in a developmentally relevant fashion. These organoids are amazing and contain all NC cardiac tissues! https://t.co/IzV8B9Wrep

This week: Colin O'Hern and a team in Dr. Aitor Aguirre's (@aaguirrecano) lab at @michiganstateu made heart-macrophage #assembloids that allow them to model heart #arrhythmias. 🫀 @CellStemCell paper - https://t.co/0PSazoI4kE Discussion - https://t.co/hMbd02QRbO

To investigate the role of embryonic cardiac tissue-resident macrophages (TRMPs) in human heart development, the @aaguirrecano lab and collaborators developed a human heart-macrophage assembloid. They demonstrated that this system can be used for mechanistic studies of

Cardiomyocyte-macrophage coupling confirmed in human cells 😍 👇 Human heart-macrophage assembloids mimic immune-cardiac interactions a...

Our new paper in Cell Stem Cell introduces human heart–macrophage assembloids (hHMAs) — the first 3D model of immune–cardiac interactions. A leap forward for human NAMs and cardiac disease modeling! Big congrats to Colin O'Hern for this work! https://t.co/F6n5RSAgfq

Check out most recent paper in collaboration with Conchi Estaras at Temple University: https://t.co/2f9yXVLf71

🫀 Human cardiac organoids are complex, self-organizing 3D tissues that recapitulate human physiology. Check out these studies by @IdanRHaim, @MDCaspi, @KostinaAleksa, @aaguirrecano, & others in @CircHF, @BISCRM, @cddpress, & @stemcellreports.

Credit goes to @frankteoh

This is a terrific podcast about our recent mini-heart work. It is surprisingly engaging and easy to follow! https://t.co/xt3lLE5RL9

Back in sunny San Diego!

Credit goes to Aleksandra Kostina, a postdoc in my lab that spear-headed this challenging project! Fantastic work Aleksandra! @KostinaAleksa

We have a funded graduate student open position open to work on heart organoids and heart failure, if any current MSU students are interested, please send me an email or message here on Twitter. https://t.co/mPWZDtxAWD

The MSU Pharmacology & Toxicology has just posted a tenure-system Associate/Full Professor position for a visionary MSU Drug Discovery Director to lead the next growth phase in MSU's drug discovery program. https://t.co/ovf6qBknah

Human heart assembloids with autologous tissue-resident macrophages recreate physiological immuno-cardiac interactions https://t.co/LnRKLsUFUG #biorxiv_bioeng

Credit goes to Colin O'Hern, an incredibly talented and hard-working DO/PhD student that performed the bulk of these work!

We further demonstrated the hHMA model’s potential by developing a platform to simulate cardiac arrhythmias, successfully replicating key characteristics of inflammasome-mediated atrial fibrillation, which may provide an invaluable resource for studying arrhythmogenesis.

The inclusion of macrophages significantly enriched the assembloid’s development, enhancing cellular communication, extracellular matrix remodeling, ventricular morphogenesis, and sarcomeric maturation.

An arrhythmic heart-macrophage assembloid from a new model for atrial fibrillation developed in our pre-print.

A macrophage integrated into the cardiomyocyte syncytium.

I am pleased to present the latest work from our lab, a human heart-macrophage assembloid model powered by self-organization that incorporates autologous cardiac embryonic macrophages into human pluripotent stem cell-derived heart organoids: https://t.co/i5nzpdq6kc