https://t.co/5CTDaUX650

Informed consent is a thing. Most people facing a potentially crippling or lethal illness have a much greater risk tolerance against 'well maybe item 6 of 11 didn't do much to help here in retrospect' than you likely think. That already happens often in routine practice anyway!

If in doubt, *ask the patient*. People have a fundamental right to participate in their own health-- *they already do so 99% of the time anyway*. 'This might help with X; it's a bit less certain; may cause Y side effects; studies say usually well-tolerated; do you want to try?'

For a medical audience: - decide what the word "evidence" means: a) "clinical results with appropriate sample(s) and endpoints" b) "what huge lumbering institutions claim ex cathedra with no citations" c) "what gilead et al. claim" d) "peer best practices" - take low-risk bets

Again, the most useful points for a broad audience: - get vaccine ASAP; prefer mRNA or Novavax; 2 doses far better than 1 - store RCT-validated early treatments: bromhexine-or-ambroxol + nitazoxanide-or-niclosamide, fluvoxamine, ivermectin - N100 masks https://t.co/DmV3mQOxPL

Reuse of N95 and related masks, a review of 42 studies https://t.co/PqnC5kzlrW Comparison of merits of 5 different methods for retaining filtration https://t.co/PqnC5kzlrW @JAMA_current by @MSchumm90 and colleagues @UCLAHealth 😷

Current COVID-19 national vaccine coverage scoreboard-- https://t.co/ILtv2uewcX

The prototype and story of a #LongCovid individual: young, healthy and mild illness https://t.co/Agynu0FRhp @LancetRespirMed

.@NBCNews: The CDC is set to release new guidelines on Thursday for Americans who have been fully vaccinated that say it’s OK for them to gather in small groups indoors with other people who have also been fully vaccinated, without wearing masks.

If Marshall or Jenner ran their now famous experiments today, they would likely be written off as curiosities.

This truly is the time of the cicadas. Every strategy with merit deserves its own time in the sun. 🌥️🌤️☀️ 📈 Or moonlight, clandestine economy, filling gaps even at edges, choke points. 🌑🌒🌓🌔🌕🎴 Sometimes even spectacular. Fly.... ☄️ Glory to the forgetful. ⏳⌛

The continued failure to trial or use ITPP in critical care is an indictment against the regulatory and productive institutions of our supposedly-advanced (increasingly just shorthand for 'gridlocked') economy. https://t.co/Jw64FfUtvA It makes blood transport oxygen better.

By the way I wrote that wiki article too. No one else was doing it. Someone had to stand up.

@patrickc @balajis If you want a real impact in reducing ICU deaths, look into ITPP, while doing cyproheptadine and fluvoxamine. Yes I know I am terrible with DMs. Yes I know I am handicapped by pseudonymity. I will never use WhatsApp. Just do it. My issues are irrelevant.

The fact that we are jamming tubes down people's throats before giving this, or for that matter even giving cyproheptadine, absolutely disgusts and appalls me. >Oh that isn't proven Yes. It. Is. READ A BOOK; THEY ARE BOTH LITERALLY BASIC PHYSIOLOGY. https://t.co/bpNAinB7av

It costs practically nothing. Thousands of people already use it for athletic activities. It has no side effects, is safe at huge doses in animal studies, and has never had a serious adverse event reported in the community ('that's informal' it's post-marketing surveillance..).

The continued failure to trial or use ITPP in critical care is an indictment against the regulatory and productive institutions of our supposedly-advanced (increasingly just shorthand for 'gridlocked') economy. https://t.co/Jw64FfUtvA It makes blood transport oxygen better.

Remembered: badly needed to link the dual entry inhibition thread; people keep not recalling what it is. Basically-- One of: - bromhexine - ambroxol - maybe-camostat (but highest dose needed...) And: - Nitazoxanide - Niclosamide - RCT: HCQ (sry but yes) https://t.co/DyxrurwEVg

Example: this article from ABC is blatantly inaccurate. https://t.co/cIHLplzlW7 66% for J&J is for *moderate* cases, whereas 95% for mRNA is for *any case at all by RT-PCR*. It is absolutely incorrect to compare these figures, like comparing choking to hiccups.

Many media outlets are reporting the 66% figure as though it were for mild cases. That interpretation is totally incorrect; the company plainly states that it is for *moderate* cases: https://t.co/OykSWYGxLi Definitions for moderate and severe broadly match prior literature:

Single-dose frankly seems gimmicky, in a very specific sense: This is effectively just offloading the debate about whether to halfway-dose existing vaccines to a new vaccine candidate instead-- one that has actually been trialed in this dosing schedule.