Zondlo Lab
@ZondloLab
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Chemical biology/bioorganic chemistry and other such shenanigans. Ruthless multidisciplinarians.
University of Delaware
Joined April 2014
Today’s Organic 1 class covered diastereomers, resolution, and asymmetric catalysis. The Chemistry @NobelPrize #chemnobel fit in perfectly. So I ended class with a song. With apologies to @DollyParton: “Proline” sung to Jolene. Congratulations @ListLaboratory @MacMillan_Lab!
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And a notification that the just-accepted paper has also been chosen to feature of the journal front cover! Details to follow on publication!
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On @ChemRxiv, we describe the synthesis of the novel amino acid 2-mercaptophenylalanine (via a copper-mediated cross-coupling reaction with an N-terminal 2-iodo-Phe on solid phase) and its application in NCL as a phenylalanine surrogate. https://t.co/gXqEOdnG1q
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One paper accepted today and also one new manuscript appearing on @ChemRxiv makes for a good day.
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Gordon Conference karaoke also reminds me that Gen Z properly loves Joan Jett. And that their parents are decidedly Gen X.
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Though it should be noted that Erick seemed particularly enthusiastic about singing multiple songs from Queen.
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I had my doubts about Gordon Conference karaoke. I was wrong. Do you wonder what it’s like to see Erick Carreira sing “Country Roads” or Rick Danheiser enthusiastically belt out “Sweet Caroline”? Exactly.
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Microsoft, all we’re asking for in Word is for the ability to place or subtly move individual graphics without playing random reformatting roulette, with graphics and text flying everywhere, never to return whence they came.
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Check out our work on protein editing!
A pair of split inteins—small protein segments that can undergo a self-sustained protein splicing reaction—enables endogenous protein editing in living mammalian cells, according to a new study in Science. 📄: https://t.co/s8Oz1zFvWf
#SciencePerspective: https://t.co/7qggLI9bSu
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“I’ve got 4 Red Bulls and a dream.” - one student’s proclamation on arriving to take his Organic 1 final.
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Grad student tuition used to be an accounting charge for students serving as TAs ($ via undergrad tuition) or RAs (grant $). Upper administrations have (1) ridiculously increased grad tuition costs and (2) weaponized them to extract real $$$ from colleges, departments, grants.
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They blame the union contract, but the key quote here is the casual line “The university also continues to pay for Ph.D. students’ tuition.” This is the shell game that upper administration is using, hard, to squeeze colleges of arts and sciences and departments.
.@BU_Tweets Suspends Admissions to Humanities and Social Science Ph.D. Programs The university didn’t announce its decision in a news release and hasn’t fully explained it, but two deans blamed a new grad workers’ union contract for the cutbacks to a dozen programs including
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At a department faculty meeting, discussing the dramatically new budget model that is being imposed on us by upper administration and by our college. The model is obviously dramatic and disastrous. Our university and college are trying to kill us.
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Please join me in welcoming Dr. Megh Raj Bhatt to @MontclareLabs! Megh received his Ph.D. in Biochemistry from @ZondloLab at @UDelaware. He will be conducting research on protein engineered materials fortherapeutic applications. #postdoclife #lablife
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Student during office hours: “What year did you start teaching here?” me: “2001” Student: “That’s so cool! My Mom’s friend said he took organic chemistry from you in 2003! He said he loved it!” … So that’s a new one. I am now into a second generation of students taught. #old
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Electronic Control of Polyproline II Helix Stability via the Identity of Acyl Capping Groups: the Pivaloyl Group Particularly Promotes PPII (Megh R. Bhatt and Neal J. Zondlo @ZondloLab)
chemistry-europe.onlinelibrary.wiley.com
The polyproline II helix (PPII) is stabilized by n→π* interactions. The ability to tune PPII structure in water via changes in the electronic properties of the acyl capping group is demonstrated...
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