Thrilled to see our paper now published @Cell_Metabolism led by @FabianPassini: Piezo2 in sensory neurons regulates systemic and adipose tissue metabolism (1/5 🧵) https://t.co/9auzEn5Wf3

🏆👩‍🔬Big congratulations to our PhD student Elisheva for winning Best Poster at the D. Dan and Betty Kahn Symposium: Frontiers in Biomedicine! 🎉 Great recognition for outstanding science!

We're proud to share that the Weizmann Institute of Science has been ranked 6th in the world in the 2025 @cwtsleiden Ranking - a jump of four places from the 2024 ranking and our highest position since the ranking was introduced some two decades ago >> https://t.co/YNbQnHGe0S

Great food, great company — and a warm welcome to our newest lab members 🍜

Exciting to see our work featured on Weizmann wonder wander! Congrats @FabianPassini

Celebrating Eli’s birthday with our traditional homemade poppyseed cake. Happy birthday, boss! 🍰🎉

We're so proud of our PhD student Elisheva Berent-Barzel for receiving an honorable mention for the 2025 Student Award for Volunteering and Diversity Promotion! We admire your dedication — to both science and community 👏👏

Great Preview by Dr. Tseng et al. on our back-to-back studies with the Patapoutian lab in Cell Metabolism! Both reveal how PIEZO2+ sensory neurons regulate fat by inhibiting sympathetic output—shedding light on adipose tissue surveillance & metabolism. 🔗 https://t.co/K9Go0ve8Rl"

Science is hard, but at least our outfits are peer-reviewed 🌶️

Exciting news! Our paper, "Piezo2 in sensory neurons regulates systemic and adipose tissue metabolism," was selected for the Editors' Choice section of @scisignal ! 🎉🔬 Check out the highlight here: 🔗 https://t.co/ApNbEXH6hh @FabianPassini

Huge thanks to all co-authors and collaborators: @BavatBornstein, @SarahRu63600780, @KupermanYael, Sharon Krief, @EviMasschelein, Tevie Mehlman, Alexander Brandis, @AddadiSefi, Shira Huri-Ohev Shalom, @proferikrichter, Tal Yardeni, Amir Tirosh, @BockKatrien and @ZelzerLab! (5/5)

This suggests a new model: Mechanoregulation by Piezo2 in sensory neurons prevents systemic hypermetabolism and adipose tissue thermogenesis. (4/5)

Surprisingly, we observed browning and beiging of adipose tissues in these mice and found Runx3/PV sensory innervation in brown and beige fat, while we found no apparent alterations in muscle metabolism. (3/5)

We found that deleting Runx3/PV sensory neurons or Piezo2 in these neurons causes systemic metabolic changes - reduced body fat, increased glucose tolerance and insulin sensitivity. (2/5)

Had the pleasure of hosting the @SharirLab today for a great mix of science, fun, and Mexican food! Looking forward to our next gathering in Ein Karem! 🌮🧪

Spent a beautiful day in Ein Karem celebrating @FabianPassini before he heads back to Switzerland. Grateful for the memories, collaborations, and friendship during his postdoc. Wishing him all the best in this next chapter! 🇨🇭

Rocking health week @WeizmannScience Sure thing we had a bowl🥣 (pun intended)

It takes a village! We thank all of our coauthors: @SeewaldAnne, @SternTomer, @paulvilloutreix, Adrian Baule, Meng-Jia Lian, Olivia Gottdenker! Go read our paper for more details https://t.co/eoE4bTwkf6 (10/10)

Moreover we propose the ratio of cluster and column formation in the growth plate is a cellular mechanism to control the elongation and expansion of the bone, which is required at different rates throughout development.(9/10)

This shift in growth strategy correlates with the loss of clusters and gain of columns in the postnatal growth plate central region. This suggests that the morphological function of columns are to promote bone elongation, while clusters may play a role in bone widening.(8/10)