Thrilled to see our paper now published @Cell_Metabolism led by @FabianPassini: Piezo2 in sensory neurons regulates systemic and adipose tissue metabolism (1/5 🧵).

Exciting to see our work featured on Weizmann wonder wander! Congrats @FabianPassini.

Join millions who have switched to Grok.

Celebrating Eli’s birthday with our traditional homemade poppyseed cake. Happy birthday, boss! 🍰🎉

We're so proud of our PhD student Elisheva Berent-Barzel for receiving an honorable mention for the 2025 Student Award for Volunteering and Diversity Promotion! .We admire your dedication — to both science and community 👏👏

Great Preview by Dr. Tseng et al. on our back-to-back studies with the Patapoutian lab in Cell Metabolism! Both reveal how PIEZO2+ sensory neurons regulate fat by inhibiting sympathetic output—shedding light on adipose tissue surveillance & metabolism. 🔗 .

Science is hard, but at least our outfits are peer-reviewed 🌶️

Exciting news! Our paper, "Piezo2 in sensory neurons regulates systemic and adipose tissue metabolism," was selected for the Editors' Choice section of @scisignal ! 🎉🔬.Check out the highlight here: 🔗 .@FabianPassini.

Huge thanks to all co-authors and collaborators: @BavatBornstein, @SarahRu63600780, @KupermanYael, Sharon Krief, @EviMasschelein, Tevie Mehlman, Alexander Brandis, @AddadiSefi, Shira Huri-Ohev Shalom, @proferikrichter, Tal Yardeni, Amir Tirosh, @BockKatrien and @ZelzerLab! (5/5).

This suggests a new model: Mechanoregulation by Piezo2 in sensory neurons prevents systemic hypermetabolism and adipose tissue thermogenesis. (4/5).

Surprisingly, we observed browning and beiging of adipose tissues in these mice and found Runx3/PV sensory innervation in brown and beige fat, while we found no apparent alterations in muscle metabolism. (3/5).

We found that deleting Runx3/PV sensory neurons or Piezo2 in these neurons causes systemic metabolic changes - reduced body fat, increased glucose tolerance and insulin sensitivity. (2/5).

Had the pleasure of hosting the @SharirLab today for a great mix of science, fun, and Mexican food! Looking forward to our next gathering in Ein Karem! 🌮🧪

Spent a beautiful day in Ein Karem celebrating @FabianPassini before he heads back to Switzerland. Grateful for the memories, collaborations, and friendship during his postdoc. Wishing him all the best in this next chapter! 🇨🇭

Rocking health week @WeizmannScience Sure thing we had a bowl🥣 (pun intended)

It takes a village! We thank all of our coauthors: @SeewaldAnne, @SternTomer, @paulvilloutreix, Adrian Baule, Meng-Jia Lian, Olivia Gottdenker!.Go read our paper for more details.(10/10).

Moreover we propose the ratio of cluster and column formation in the growth plate is a cellular mechanism to control the elongation and expansion of the bone, which is required at different rates throughout development.(9/10).

This shift in growth strategy correlates with the loss of clusters and gain of columns in the postnatal growth plate central region. This suggests that the morphological function of columns are to promote bone elongation, while clusters may play a role in bone widening.(8/10).

Finally, comparing rates of bone elongation vs widening revealed that during embryonic stages bones undergo both elongation and widening at similar rates, while during postnatal stages bones stop widening and only elongate. (7/10).

Our findings point to the division plane rotation as a key cellular regulator of column vs cluster formation in which surpassing a critical threshold of incomplete rotations will drive the formation of clusters over columns. (6/10).

During postnatal bone development, complete division plane rotations are more prevalent, leading to the formation of large columns with complex morphologies. (5/10).