Yeates Lab
@Yeates_Lab
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Lab twitter account for the Todd Yeates group @UCLA
Joined September 2022
Our new paper that uses machine learning to generate a suite of novel protein cages has just been published:
cell.com
Using machine learning and knowledge-based algorithms, Meador et al. design 24-subunit protein complexes in the shapes of tetrahedral nanoparticles or cages. Structural and biochemical methods...
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Our creation of 'ligand-operable cages' -- designed protein cages that disassemble when they bind a specific cellular protein -- has been published:
pubs.acs.org
Protein nanocages have diverse applications in medicine and biotechnology, including molecular delivery. However, although numerous studies have demonstrated the ability of protein nanocages to...
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Our latest work on solving the cryo-EM problem for small therapeutic proteins is finally out. Congrats to Roger and the lab!.
pnas.org
Cryoelectron microscopy (Cryo-EM) has enabled structural determination of proteins larger than about 50 kDa, including many intractable by any othe...
I'm thrilled to share our latest work on designing imaging scaffolds to determine the structure of small proteins using cryo-EM!.
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‘Rigidified Scaffolds for 3-Angstrom Resolution Cryo-EM of Small Therapeutic Protein Targets’.Congrats @rcastellsg @kylemeador and team!.With our imaging scaffolds, we report a 2.9A structure for a ~19 kDa KRAS protein oncogenic mutant.
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