🧠 Curious about how neurons are wired in the human cortex?. Our @ScienceMagazine study tested over 7,000 connections and revealed key differences from rodents:."Directed and acyclic synaptic connectivity in the human layer 2-3 cortical microcircuit". 🧵👇

I would like to thank everyone involved from the.@MRCBNDU and our collaborators. Special thanks to my great postdoc supervisor Andrew Sharott and his lab. I really enjoyed my time in this very supportive and inspiring scientific environment. Stay tuned for more to come.

Delighted to share my postdoc project on We used multi-Neuropixels during reaching and found preserved population dynamics across regions, sessions and animals that are not only linked to movement, but also the continuous expectation of action outcome.

RT @JilMeier: 📢OPEN PHD POSITION 📢. Looking for a PhD and interested in neuromodulation?. Then come work with me, @_PetraRitter and the @Re….

RT @neumann_wj: As young PI it's so exciting to see young talents excel. New @ICNeuromodulate study spearheaded by @rm_koehler out in @Brai….

If you want to see really awesome axon physiology in humans. Definitely check out @FMittermaier’s Poster at @FENSorg! 🔥.

RT @FMittermaier: Visit my poster at the FENS (Thursday-late breaking session), where we investigate cellular and synaptic mechanisms which….

🎓📢 Exciting PhD opportunity in translational neuroscience! As a new group within the @Retune_CRC, we apply large-scale electrophysiology to better understand Parkinson's disease and Deep brain stimulation. See call below and catch me at FENS. Homepage:

RT @florin_neuro: Yet another open PostDoc/PhD position in our group. Interested in Parkinson's disease, MEG and inctracranial recordings?….

RT @NaN_Value: Modulating networks using DBS is an effective treatment for PD – but which circuits map to improvements in individual sympto….

RT @chayito09: Contrario a lo que se creía, las células nerviosas en la neocorteza humana se comunican en una dirección, mientras que en lo….

For more details, check out the tweeprint 😉.

The @ChariteBerlin science communication team has written a great press release for the lay audience. Check it out here:

So excited that our human multipatch study has been finally published in @ScienceMagazine 🥳. Thanks so much to the @ChariteBerlin science communication team who wrote an excellent press release!.

If you are interested in this kind of research (or large-scale in-vivo recordings to study movement), please reach out! I am recruiting PhD and postdocs for a new lab 😉. 🔗

Special thanks to Antje Bjelde and Pau V. Aceituno for their crucial analytical contributions, and to @FMittermaier and Henrike Planert for helping with the challenging experiments. None of this would have been possible without Jörg Geiger's vision and guidance.

For more details, please see our paper: For a detailed characterization of the cellular and synaptic physiology, see our preprint: This was a great collaborative effort between @ChariteBerlin, @NeuroCureBerlin with @evkb and @ETH.

How does this increased dimensionality impact computation? In a speech recognition task, "rodent-like" networks had a lower performance compared to random networks, while "human-like" acyclic networks achieved the highest task performance, due to its more flexible representation.

To investigate the effect of the identified microcircuit principles on network dynamics, we turned to Pau V. Aceituno and Benjamin Grewe from @ETH. In simulated neural networks, random reciprocity, acyclicity and random weight distribution increased network dimensionality.

In addition to heterogenous and spatially directed connectivity, we also found a strong underrepresentation of cyclic motifs. Such a directed and acyclic graph topology means that local connectivity can be understood as hierarchical feed-forward networks.

We further found an increased directionality in the network that was partially due to a spatially asymmetric connectivity along the axo-dendritic axis: Neurons preferrably connected with neurons positioned deeper than themselves. Possibly supporting intralaminar information flow.