Yaíma Lightfoot
@YaimaLightfoot
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Immunologist | Brain enthusiast | Mother | Wife | Alzheimer’s Disease drug discovery sci. (NDC @MDAndersonNews). Views are my own. She/her(s). 🇨🇺🇺🇸
Houston, TX
Joined January 2022
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RT @DrMicroglia: Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonica….
nature.com
Nature Communications - Microglia are professional phagocytes in the CNS. However, which cells scavenge corpses of microglia is largely neglected. Peng and colleagues found that nonprofessional...
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RT @JimRayNDC: NDC Retreat 2022! We covered 10 new drug discovery programs in 8 hours…my brain hurt but was great!
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RT @JimRayNDC: Check out our new website! Alzheimer’s disease drug discovery, new targets, you know all the good things in life. Like and….
belferndc.org
The Belfer Neurodegeneration Consortium (BNDC) mission is to discover breakthrough therapies that slow, stop, or reverse neurological disorders such as Alzheimer’s disease and Parkinson’s disease.
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RT @JiachengMa_NDC: We are hiring at the Neurodegeneration Consortium #NDC! Great opportunity if you are interested in neuroscience and dru….
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RT @Andy_P_Tsai: Congratulations to @mightymicroglia @BlurtonJonesLab and Hayk for the new findings demonstrating the hypermorphic protecti….
alz-journals.onlinelibrary.wiley.com
The P522R variant of PLCG2, expressed by microglia, is associated with reduced risk of Alzheimer's disease (AD). Yet, the impact of this protective mutation on microglial responses to AD pathology...
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RT @JiachengMa_NDC: TRPML1 inhibition by LAMTOR1 is critical for regulating dendritic lysosomal motility, synaptic plasticity, and learning🤔.
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Promising strategy to target AD risk-associated CD33 with small molecules #microglia #neuroinflammation #EndALZ #drugdiscovery .
pubs.acs.org
CD33/Siglec 3 is a myeloid lineage cell surface receptor that is known to regulate microglia activity. Multiple genome-wide association studies (GWAS) have identified genetic variants in the CD33...
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RT @Brain1878: Jackson et al. demonstrate that allele-specific knock-in mice expressing humanized APOE ε4, but not APOE ε2 or ε3, show a le….
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Thank you @JimRayNDC for talking me into joining #ScienceTwitter! But #science doesn’t sleep, and now I might not either 🧬🧫.#neuroinflammation #neurodegeneration #ENDALZ.
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