WarrenLeeLab
@WarrenLeeLab
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Endothelial Biologist. ICU Physician and Scientist.
Toronto, Ontario
Joined October 2018
Agree with @MireilleOuimet. Really enjoyed CLVS2024! Great science and camaraderie.
I had an incredible time at #CLVS 2024 in Blue Mountain! Outstanding scientific presentations, and it was so rewarding to reconnect with familiar faces and meet new friends. Already excited for the 2025 meeting in Saskatoon, the "Paris of the Prairies"😉! 📷Credit:.@PatriciaLiaw
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Delighted that Erika Jang and Winnie Ho's latest work is out. LDL transcytosis across the endothelium is the first step in atherogenesis, typically involving caveolin-1 and SR-BI or ALK1. We describe a distinct route that uses LDLR and Rab27a in response to pM levels of IL-1b.
IL-1B accelerates atherosclerosis by inducing LDL transcytosis independently of caveolin-1. The pathway requires LDLR and Rab27a @WarrenLeeLab @TseWingWinnieHo.
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RT @atvbahajournals: IL-1B accelerates atherosclerosis by inducing LDL transcytosis independently of caveolin-1. The pathway requires LDLR….
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RT @CircRes: Kothari et al found that large #HDL particles hinder #LDL endothelial #transcytosis. Read more about the implications for #CVD….
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RT @gfairn: ApoAI/HDL binds and competes with LDL for SR-BI on endothelial cells, thereby partly reducing LDL transcytosis. Yet another way….
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RT @kat_howe: Directional Endothelial Communication by Polarized Extracellular Vesicle Release | Circulation Research Congrats @SnehaRajuM….
ahajournals.org
BACKGROUND: Extracellular vesicles (EVs) contain bioactive cargo including miRNAs and proteins that are released by cells during cell-cell communication. Endothelial cells (ECs) form the innermost...
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RT @drpablocorral: ☝️Must read. 👉LDL Transcytosis by the Arterial Endothelium—Atherosclerosis by a Thousand Cuts?. 😉Inflammation stimulates….
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RT @AJPLung: Today we feature a #ShortReport in our #ArticleinPress by Rajiv Sanwal et al. #Ultrasound-guided transfection of claudin-5 imp….
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Excited to share our work describing targeted transfection of injured lung. A huge effort by @RajivSanwal and collaborators. Over-expression of claudin-5 using ultrasound & microbubbles decreased vascular leakage w/o impairing innate immunity. @AJPLung.
journals.physiology.org
In acute lung injury, the lung endothelial barrier is compromised. Loss of endothelial barrier integrity occurs in association with decreased levels of the tight junction protein claudin-5. Restora...
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Thanks to our terrific collaborators including @TorresVJ_Lab, @Kat_howe, @FishLab_UHN and Andras Kapus.
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Duffy antigen receptor for chemokines (DARC) or ACKR1 is expressed on endothelial cells in tissue but the protein is lost when cells are cultured. Here we report how to induce endothelial ACKR1 and how it is regulated. Congrats to Xinying Guo and @KhNegar for figuring this out!.
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Endothelial ACKR1 is induced by neutrophil contact and down-regulated by secretion in extracellular vesicles
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RT @MDPIpharma: #MDPIPharmaceutics ."Plug and Pop: A 3D-Printed, Modular Platform for Drug Delivery Using Clinical Ultrasound and Microbubb….
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Lab picnic on the island. Fun but a bit chilly; maybe should have done it before the CIHR deadline.
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First in-person conference in over two years. The students did a great job representing the lab! @GordonConf
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RT @TessaRDavis: Of all the meeting platforms we've used over the last 2 years, Zoom is the one I love most. Most of us think we know Zoom….
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Grateful for the renewal of my Canada Research Chair. And especially thankful to my terrific students and techs who make research so much fun!.
Three scientists at St. Michael’s Hospital have received prestigious research chair awards from @CIHR_IRSC and @CRC_CRC. Congratulations to Dr. @AndrewDPinto, Dr. @ATricco and Dr. @WarrenLeeLab! Read more:
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