Vito Ferro 🇮🇹🇦🇺
@VitoFerro8
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Professor @UQ_SCMB. Carbohydrate chemistry, #glycosaminoglycans, heparan sulfate mimetics, heparanase, antivirals, MPS disorders, #Sanfilippo syndrome
Brisbane, Queensland
Joined June 2020
Efficient synthesis of fluorogenic substrates for mucopolysaccharidosis (MPS) IIIA and IIIB via aromatic α-glycosylation with thioglycosyl donors - now published in Organic & Biomolecular Chemistry .#Sanfilippo #ChildhoodDementia.
pubs.rsc.org
Sanfilippo syndrome (Mucopolysaccharidosis type III, or MPS III) is an inherited neurodegenerative disorder resulting from mutations in genes encoding lysosomal enzymes that sequentially degrade...
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Gold(i) and gold(iii) complexes of triazolyl-functionalised NHCs - now published in RSC Advances
pubs.rsc.org
Novel triazolyl-functionalised imidazolium salts and their corresponding AuI/AuIII complexes were synthesised and characterised by spectroscopic techniques and X-ray diffraction studies. The reaction...
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Our latest work on a new class of HS mimetic polymers:.A Novel Series of Synthetic Heparin‐Mimetics–Itaconic Acid‐Containing Copolymers for Targeting Tumor Cell Coagulability and Metastasis - Nekipelov - Macromolecular Bioscience - Wiley Online Library
onlinelibrary.wiley.com
Heparin is postulated to possess antitumor properties- beyond its anticoagulative activities in oncology, but disclosure of targeted activities is complicated by heparins structural variabilities as...
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RT @rheabains: Excited to share that our work on sulfated oligosaccharide and glycan synthesis is now live in @J_A_C_S ! Check it out https….
pubs.acs.org
Sulfation is a common, but poorly understood, post-glycosylational modification (PGM) used to modulate biological function. To deepen our understanding of the roles of various sulfated glycoforms and...
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RT @VinodKTiwari6: We sincerely thank Prof. Vito Ferro for invited contribution on 'Synthesis of a deuterated disaccharide internal standa….
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Last paper of the year from a collaboration with the Ronzoni Institute. Congratulations to Minghong Ni & co.
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Synthetic Access to l-Guluronic Acid via Fluorine-Directed C-5 Epimerization | The Journal of Organic Chemistry From the PhD work of Dr Nick See. Well done Nick!.
pubs.acs.org
l-Guluronic acid is integral to the structures of alginates and to the pathogenesis of Pseudomonas aeruginosa. The exploitation of this hexose in both existing and new contexts is, however, limited...
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A Heparan Sulfate Mimetic RAFT Copolymer Inhibits SARS‐CoV‐2 Infection and Ameliorates Viral‐Induced Inflammation - Ling - Advanced Science - Wiley Online Library
advanced.onlinelibrary.wiley.com
This study identifies a unique HS mimetic, HMSA-06, that inhibits different types of SARS-CoV-2 cell entry and viral replication by boosting autophagic flux, potentially serving as the first line of...
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RT @JOC_OL: A modern Ferrier photobromination and F-directed reduction convert D-ManA to L-GulA, featuring a photochemical resolution to se….
pubs.acs.org
l-Guluronic acid is integral to the structures of alginates and to the pathogenesis of Pseudomonas aeruginosa. The exploitation of this hexose in both existing and new contexts is, however, limited...
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RT @SFCFoundtn: Wondering why landmarks in Australia are lighting up purple tonight? Raising awareness of Sanfilippo syndrome and our amazi….
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RT @marquelawyers: 49 anti-protest laws in 20 years! @crikey_news
crikey.com.au
Pro-Palestine marches and rallies across Australia have sharpened a long-developing governmental desire to crack down on protests.
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Synthesis of a deuterated disaccharide internal standard for LC-MS/MS . .1st paper from the PhD of Yuchen Pan on the improved synthesis of an MS standard used for assaying heparan sulfate for #Mucopolysaccharidosis #Sanfilippo research.
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RT @ChemEurJ: Origins of Temperature-Dependent Anomeric Selectivity in Glycosylations with an L-Idose Thioglycoside (Elizabeth H. Krenske,….
chemistry-europe.onlinelibrary.wiley.com
Computational modelling reveals the key mechanistic details explaining why glycosylations involving L-idose thioglycoside donors, and potentially also a wide range of other donors, become increasin...
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RT @ACSBioMed: Read about amphiphilic heparinoids as potent antiviral agents against SARS-CoV-2 in #JMedChem. Collaboration between @VitoFe….
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Check out my seminar titled Exploiting the fluorine-directing effect to access rare L-hexoses .@thiemechemistry.
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Site-Selective Photobromination of O-Acetylated Carbohydrates in Benzotrifluoride | Organic Letters .Now with page numbers. #glycotime.
pubs.acs.org
Ferrier photobromination enables direct synthetic access to valuable 5-C-bromosugars but has limitations that restrict its broader use. The reaction is typically conducted in CCl4 heated at reflux...
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RT @SFCFoundtn: We’re delighted to see Prof Hemsley and Dr Lau have received Flinders Foundation funding to pursue combination therapy with….
flindersfoundation.org.au
At Flinders Foundation, our purpose is you. We raise money for research, treatment and equipment, so that our community, can live a longer and happier…
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Amphiphilic Heparinoids as Potent Antiviral Agents against SARS-CoV-2 | Journal of Medicinal Chemistry Collaboration between @VitoFerro8 & @raghavendrakik1 & many others! From the PhD work of @Mohit_Chh at @UQ_SCMB and C.D. Shanthamurthy at @IISERPune.
pubs.acs.org
Herein, we report the synthesis and biological evaluation of a novel series of heparinoid amphiphiles as inhibitors of heparanase and SARS-CoV-2. By employing a tailor-made synthetic strategy, a...
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Origins of Temperature‐Dependent Anomeric Selectivity in Glycosylations with an L‐Idose Thioglycoside - See - Chemistry – A European Journal - Wiley Online Library .Another publication from the PhD work of Dr Nick See. Congratulations Nick!.
chemistry-europe.onlinelibrary.wiley.com
Computational modelling reveals the key mechanistic details explaining why glycosylations involving L-idose thioglycoside donors, and potentially also a wide range of other donors, become increasin...
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