After ~2 years of preparation, we’re all set for the @GordonConf on Fertilization! Excited for great talks, engaging discussions, and reconnecting with this amazing community. @ShwetaBhagwat3 @lucajovine & Rafael Fissore #GRC #Fertilization

Together with @EstermannMartin we curated a preList of #preprints presented at the @KeystoneSymp Metabolic and Nutritional Control of Development and Cell Fate! .Explore the latest in the field — fresh from the conference! 📑🆕️.Link: #DevBio #Metabolism.

6/6 Want the full picture? Check out our preprint, or reach out to any of the amazing authors who made this story possible >>.@steinpau.bsky.social 🦋.@martinestermann.bsky.social 🦋.@williamsrepro.bsky.social 🦋 Lenka Radonova.

5/6 The exciting part? This abnormal calcium-induced epigenetic reprogramming can be rescued by adding exogenous lactyl-CoA, which restores global H3K18la and global transcription at the 2-cell stage.

4/6 And guess what? We demonstrated that calcium signals at fertilization function as a metabolic regulator, altering the availability of lactate and lactyl-CoA. This, in turn, affects H3K18la and impairs Pol I-driven EGA

3/6 The answer came during our MATEbolism Journal Club, where we learned that lactylation acts as a molecular switch, linking metabolism and chromatin remodeling, and that H3K18-lactylation (H3K18la) and RNA pol-I activity are key for EGA and embryo development

2/6 Using genetic mouse models or ionomycin treatment to increase calcium exposure, we showed that excess calcium leads to high H3K27ac marks but drastically reduces global transcription at the 1-cell and 2-cell embryo stages. But for the longest time, we couldn’t understand HOW!.

1/6 🧵 I am beyond excited to share the latest work from @williamsrepro 🦋! This story began during the pandemic as we sought to understand how a brief insult during the peri-fertilization window can escalate into a metabolic outcome in adulthood—as seen in IVF-conceived children.

The 2025 season of MATEbolism Journal Club is now on! Over the last year, with @EstermannMartin, we’ve explored how metabolism controls cell fate and epigenetics—while we metabolize cakes and snacks. Science fueled by sugar is back!! #Metabolism #Epigenetics

Feliz de compartir nuestra ciencia con la hermosa comunidad de Reproseminars! .Nos vemos este lunes 21 de Octubre!!!.

RT @alsina_fc: Our lab @StJudeResearch is recruiting! We have postdoc and technician positions available. Please apply (links below) if yo….

What a great experience meeting, working and learning from @WinRS_SSR !.

10 impressive women in STEM!! Pick it up, kee0 moving, and follow these women:.@PaulaStein3 @LRadonova @FarnersRiera @taniokinn @BlenginiCecilia @MaGraciaGervasi @MariaBlasi6 @IralaDolores @emipanzetta @Maribelnm.

RT @NobelPrize: This year’s medicine laureates Victor Ambros and Gary Ruvkun studied a relatively unassuming 1 mm long roundworm, C. elegan….

RT @GamarnikLab: The Milei government is cutting education funding in Argentina. TODAY, 1 million people are in the streets defending publ….

Thrilled to see a friend shining! 🎉 And Happy 1st anniversary to the Amargant i Riera lab! So excited for all the groundbreaking discoveries on mechanobiology, aging & PCOS coming your way.

Parece chiste, pero no. ojalá lo fuera. #UniversidadPublicaArgentina #UniversidadGratuita.

#UniversidadPúblicaArgentina es un orgullo y no se toca. Como sea y desde donde sea, siempre defendiendola!

An outstanding leader and role model! Thank you for your dedication to making @WinRS_SSR a supportive space to learn, grow, and advocate for gender equality in @SSRepro, @KASchindler27.

It was an honor to have you as the morning keynote speaker! Very inspiring talk and career! Thanks for joining us! @NIEHS #RDBL.