Elsa Anagnostou
@ValsamoA
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Director, @MolecularOncLab & @HopkinsThoracic Biorepository Co-leader, Molecular Tumor Board @hopkinskimmel . Bringing multi-omics discoveries into IO trials.
Baltimore, MD
Joined January 2020
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#KRAS
alert! Over the past 4 years, a multi-disciplinary team from
@hopkinskimmel
@VUMC_Cancer
@DanaFarber
@MSKCancerCenter
&
@Amgen
has been studying the distribution and co-mutations of KRAS, NRAS and HRAS mutant
#cancers
under the auspices of
@AACR
project
#GENIE
. Read the 🧵
6
107
309
Hot off the press in
@NatureMedicine
: Pleased to see stage 1 of our
#ctDNA
molecular response adaptive
#clinicaltrial
in print, supporting the value of ctDNA as an early endpoint of
#immunotherapy
response for patients with
#lungcancer
. 👉
#OpenAccess
link:
3
66
206
Excited to announce that I was promoted to Associate Professor! So many mentors, peers and family to thank during this journey from
@uoaofficial
to
@YaleMed
and
@hopkinskimmel
!
@HopkinsThoracic
@MolecularOncLab
16
6
106
Welcome to the world BR.36! Just out in
@NatureMedicine
here's stage 1 of our
#ctDNA
response-adaptive
#immunotherapy
#clinicaltrial
.
Big thanks to our patients
@CDNCancerTrials
@CancerResearch
@TheMarkFdn
@hopkinskimmel
&
@PGDx_
for making this happen.
6
31
94
Adjuvant and neoadj immunotherapy are increasingly incorporated in clinical care for patients with early stage
#lungcancer
. How can we enrich for the population most likely to benefit? Can ctDNA help?
Read together with
@JackWestMD
0
32
82
Here's our latest at
@jitcancer
, led by star
@HopkinsThoracic
@MolecularOncLab
@hopkinskimmel
oncology fellows
@JennaCanzoniero
, Michael Hwang and
@Sam_Rosner_
and just-in-time for
@Hopkins_HemOnc
#graduation
! 1/n
New
#JITC
article: Peripheral blood immune cell dynamics reflect antitumor immune responses and predict clinical response to immunotherapy
@SmithImmunology
@JulieBrahmer
@FordePatrick
@ValsamoA
0
17
43
1
27
78
Check out the
@jitcancer
Special Series on Liquid Biopsies!
@md_stewart
@CancerResrch
@sitcancer
@hopkinskimmel
0
34
74
Paper alert! 7 years in the making, our newest study was just published in
@NatureMedicine
: Durvalumab with chemotherapy for
#mesothelioma
; Survival,
#Genomics
and Immunologic Analyses from the PrE0505
#clinicaltrial
.
@hopkinskimmel
@PrECOGonc
#tweetorial
2
19
74
Humbled to receive the
@isliquidbiopsy
research award at
#ISLB23
, thank you
@ChristianRolfo
@UmbertoMalapel1
@ElJanLe
@MJOSESERRANO19
@drgandara
@MCristofanill
, so much promise in
#liquidbiopsies
changing precision medicine!
@hopkinskimmel
@HopkinsThoracic
@MolecularOncLab
@isliquidbiopsy
reasearch award goes to
@ValsamoA
!! Congrats Elsa! Well deserved!
@ChristianRolfo
@drgandara
@ElJanLe
@MCristofanill
@MJOSESERRANO19
1
12
27
5
16
71
Here’s the latest from
@HopkinsThoracic
, hot off the press in
@NatureMedicine
; our pursuit of mutations with differential weights within the overall TMB lead us to the discovery of “persistent mutations”.
Curious? Read the full article:
@hopkinskimmel
1
25
67
Cannot think of a better way to celebrate our
@NatureMedicine
#liquidbiopsy
study than with the
@MolecularOncLab
family (wet lab part pictured 😀)! Fortunate to be surrounded by such talented & driven scientists!
@LavanyaSivapal1
@MariaFatteh
@mimi_najjar
@Blair_Landon15
+ more
Hot off the press in
@NatureMedicine
: Pleased to see stage 1 of our
#ctDNA
molecular response adaptive
#clinicaltrial
in print, supporting the value of ctDNA as an early endpoint of
#immunotherapy
response for patients with
#lungcancer
. 👉
#OpenAccess
link:
3
66
206
3
13
66
Here's our latest from
@HopkinsThoracic
&
@MolecularOncLab
, hot-off-the-press in
@NatureMedicine
. What do we learn from neoadjuvant anti-PD1 & anti-LAG3 through the lens of liquid biopsies? Enjoy the read!
@vincentlamMD
@CancerResearch
@Blair_Landon15
0
25
65
Published in
@CD_AACR
ahead of
#AACR24
our vision for pushing the boundaries of
#liquidbiopsies
through transformative technologies and clinical implementation for early precision intervention.
@velculescu
@HopkinsThoracic
@AACR
1
24
64
Looking for a
#liquidbiopsy
read for the weekend? The
@jitcancer
special series, covering CTCs, cfDNA biology, existing & emerging technologies, applications in early detection, MRD & IO response monitoring, is now complete!
Visit the journal's homepage or
0
26
63
Time for a
#liquidbiopsy
thread discussing key points on the role of ctDNA as an early endpoint of immunotherapy response from our
@NatureMedicine
BR.36
@CDNCancerTrials
@CancerResearch
study. Article is available
#OpenAccess
here:
1
16
56
Congrats on your promotions
@TaxiarchisB
@FordePatrick
, so fortunate for our long-standing collaborative efforts within
@HopkinsRPQS
@Hopkins_MTB
@MolecularOncLab
and
@HopkinsThoracic
👏👏👏👏👏 !
6
6
55
Thanks
@CR_AACR
for featuring our article on RAS genomic landscapes on the journal's cover!
Wonderful to see this multi-institution,
@AACR
supported effort in print!
@christine_lovly
@DrMarkAwad
@RielyMD
@BiagioMd
@hopkinskimmel
@OncoAlert
@KRASKickers
0
22
52
New liquid biopsy kid on the block! Here’s GEMINI developed by the very talented
@HopkinsKimmel
Human Genetics
#grad
student Daniel Bruhm: a
#machine
learning model for single-molecule genome-wide mutation profile detection. Just out in
@NatureGenet
0
16
52
Looking for a weekend read on
#KRAS
biology? Here's the
@AACR
Journals' KRAS collection featuring our work on RAS atlas of co-mutations in human cancers leveraging project
#GENIE
.
@AACR_CR
@hopkinskimmel
@HopkinsThoracic
@christi
1
21
51
It's a wrap for
@AACR
Molecular Biology in Clinical Oncology, ending a week of
#CancerResearch
courses, grant writing,
#careerdevelopment
sessions, awesome mentorship and coaching with
#karaoke
night with old and new friends.
#AACR
#MBCO
2
15
48
Honored to receive the
@isliquidbiopsy
2023 Research Award! Cannot wait to join
#liquidbiopsy
trailblazers
@ChristianRolfo
@drgandara
@UmbertoMalapel1
@ElJanLe
@MJOSESERRANO19
@MCristofanill
in Madrid!
Don't miss it:
@hopkinskimmel
@HopkinsThoracic
#LCSM
7
12
49
To what extent does HLA germline variation determine tumor "visibility" and response to
#Immunotherapy
? Read our commentary with
@LavanyaSivapal1
in
@ImmunityCP
:
discussing the study of Chhibber et al.
@HopkinsThoracic
0
21
47
Great to see our latest collaborative
#liquidbiopsy
work published in
@CCR_AACR
!
#OpenAccess
article here:
@hopkinskimmel
@HopkinsThoracic
@MolecularOncLab
@AHNtoday
@NKI_nl
@sibleyonline
@AACR
0
19
49
Humbled to join
@christine_lovly
to co-chair the
@eaonc
Lung Biology subcommittee! Looking forward to working with all members of the Thoracic ECOG-ACRIN group to develop correlative
#science
for the ECOG
#clinicaltrial
portfolio. Thanks
@RamalingamMD
@DCarboneMD
@JulieBrahmer
!
4
6
48
Congrats to our stellar graduate student
@Blair_Landon15
for her scholar-in-training award for her
#AACR23
abstract on liquid biopsy analyses for patients with
#immunotherapy
treated esophageal cancer!
@CMM_JHU
@MolecularOncLab
@HopkinsThoracic
@AACR
#proudmentor
#WomenInScience
6
8
48
Congrats to our super⭐️
@MolecularOncLab
members
@Blair_Landon15
@LavanyaSivapal1
@MariaFatteh
for their
#AACR24
Scholar-in-Training awards! While the awards are theirs, the pride is contagiously mine 😁😁
@AACR
@hopkinskimmel
@HopkinsThoracic
@Hopkins_MTB
@CMM_JHU
@JHPDA
0
12
47
Excited to see the inaugural issue of
@NatureCancer
and our study Multimodal Genomic Features Predict Outcome To Immunotherapy go live!
@hopkinskimmel
#UADResearchGroup
2
11
47
Pleased to see our study Large-scale transcriptomic profiling of the tumor immune microenvironment in ALK+ lung cancer accepted for
#ASCO23
poster discussion!
@vincentlamMD
@archana__balan
@FordePatrick
@CarisLife
@HopkinsThoracic
@hopkinskimmel
@break_cancer
@ASCO
#LCSM
1
11
46
Wonderful to see our
#liquidbiopsies
research highlighted in the
#AACR24
#precisiononcology
special series!
Read the open access
@CCR_AACR
study:
@AACR
@HopkinsThoracic
@HopkinsMedicine
@LavanyaSivapal1
@josephcmurray
1
9
47
Impeccably organized
#Atlanta
#lungcancer
conference, great presentations and panel discussions and a heated debate by
@StephenVLiu
! Plus lots of
#womenpower
!
#ALCS2023
@RamalingamMD
@RielyMD
@LealTiciana
@KHigginsMD
@HopkinsThoracic
@WinshipAtEmory
0
12
46
Introducing
@Hopkins_MTB
, the official
#Twitter
account for the Molecular Tumor Board at
@hopkinskimmel
@HopkinsMedicine
. Follow us for
#tweetorials
on
#precisionmedicine
#Genomics
#biomarkers
#patient
#education
#MedEd
and more!
#TwitterFriends
spread the word!
#JHKimmel_MTB
0
23
45
Fascinated by the
#KRAS
evolution from an elusive
#target
to direct
#G12C
inhibitors.
#KRAS
G12D and KRAS
#immune
#targeting
(including
@hopkinskimmel
's own MANAbodies) are next! Great kickoff for
#AACR21
with Frank McCormick
@kevansf
Stephen Fesik
@AACR
#CelebratingScience
0
5
46
Hot off the press in
@iScience_CP
, epigenetic therapy induces viral mimicry response together with CD8 T cell infiltration in
#lungcancer
. Great team work led by Michael Topper & Steve Baylin with
@hopkins
@HopkinsThoracic
@kamarroneMD
@JulieBrahmer
2
12
45
We need more data to support the role of liquid biopsies as an early endpoint for clinical response to
#cancer
#immunotherapy
. Together with
@FordePatrick
@HopkinsThoracic
@hopkinskimmel
we just launched an
@FDAOncology
funded effort to study
#ctDNA
response for
#lungcancer
.
#LCSM
1
9
45
Congrats to our stellar
@MolecularOncLab
#oncology
fellow
@josephcmurray
for being awarded a MacMillan path to independence
#Scholarship
! Excited to see you move on to the next great step in your career Joe!
@Hopkins_HemOnc
@HopkinsThoracic
@hopkinskimmel
#proudmentor
7
6
44
2
0
41
Join us on June 11th to spread awareness about the importance of
#cancer
#immunotherapy
#research
. We strive to bring new
#scientific
#discoveries
in
#clinical
#Cancer
care. Create a future
#Immune2Cancer
with
@CancerResearch
. We are
#generation
#cure
.
#CIM21
@hopkinskimmel
0
9
41
We are thrilled to launch an
@FDAOncology
funded effort to develop a one-stop-shop
#precision
#oncology
decision-support
#informatics
platform to enhance genotype-driven
#clinicaltrials
enrollment and decentralized
#PrecisionMedicine
!
@Hopkins_MTB
@hopkinskimmel
@TaxiarchisB
1
7
40
@Hopkins_MTB
is now
@theNCI
funded! Over the next few years will intensify our efforts to generate automated precision oncology decision-support systems linking genotypes with therapies at
@hopkinskimmel
& in the community. Thanks to our great clinical-genomic-informatics team!
4
8
38
Thrilled to take upon this role together with
@josephcmurray
. Lots of work to do especially in linking next-generation sequencing with outcomes. This ties into the precision oncology efforts within the
@Hopkins_MTB
and more!
Congratulations to Drs. Elsa Anagnostou
@ValsamoA
& Joe Murray
@josephcmurray
newly appointed co-directors of the
@HopkinsThoracic
Lung Cancer Precision Medicine Center of Excellence!
#LCSM
12
10
85
2
4
40
Where do we stand with tumor mutation burden as a
#biomarker
of response for
#cancer
#immunotherapy
? Read our viewpoint and
#virtual
discussion with
@GeneCollector
@SamraTurajlic
and
@Albert0Bardelli
, just out in
#SeriesCancerImmunotherapy
@NatureCancer
0
14
40
Congrats to our amazing
@MolecularOncLab
@Hopkins_MTB
young investigators
@MariaFatteh
& Justin Huang who just presented their work in multiomic analyses of immunotherapy response & precision oncology at
#AACR24
!
@AACR
@HopkinsThoracic
@HopkinsMedicine
1
9
39
So fortunate to have been mentored by
@DavidRimm
and
@velculescu
and what a better occasion to get them both in one place than the
#AACR24
@AACR
journals reception!
3
7
39
Thoroughly enjoyed chairing & presenting at the first session of a beautifully organized
@IASLC
#IO23
conference, focusing on genomics of
#immunotherapy
resistance. Great presentations & discussion by
@NickyMcGranahan
and
@GeneCollector
! Thanks
@RobertoFerrara_
Joachim Aerts!
0
5
39
So fortunate to celebrate the holiday season with the
@MolecularOncLab
! Cannot think of a more dynamic, creative and more importantly good-hearted group of people🙏
2
9
38
Pleased to announce the Robin Adler Fellowship in Cancer Genomics & Liquid Biopsies, this is a 3yr
#postdoc
fellowship in the transformative field of
#liquidbiopsy
in the
@MolecularOncLab
at
@HopkinsThoracic
@hopkinskimmel
. DM to learn more and
#TwitterFriends
RT!
@benlevylungdoc
5
20
38
The story starts several years back, when we discovered that mutation/neoantigen loss via chromosomal deletions is linked with acquired resistance to immune checkpoint blockade.
@CD_AACR
@HopkinsThoracic
@hopkinskimmel
Here’s the latest from
@HopkinsThoracic
, hot off the press in
@NatureMedicine
; our pursuit of mutations with differential weights within the overall TMB lead us to the discovery of “persistent mutations”.
Curious? Read the full article:
@hopkinskimmel
1
25
67
1
24
38
Phenomenal scientific program in
#CICON22
, thanks
@CancerResearch
and
@AACR
for the invitation to present! Here's a recap of day 2 (from a cancer immunology-enthusiast non-expert angle😏) with some notable publications reviewed at the meeting.
Read the 🧵
#Cancer
#Immunology
1
11
37
New
#ctDNA
expert-opinion article from
@semenko
@BrunaPellini
&
@aadel_chaudhuri
part of the
@jitcancer
#liquidbiopsy
special series!
What is the value, challenges, opportunities & emerging technologies for ctDNA MRD?
@WashU_ctDNA
@MoffittNews
#OpenAccess
1
17
37
Thank you
@CancerResearch
for supporting the
@CDNCancerTrials
BR.36
#ctDNA
trial! BR.36, built on years of
#laboratoryresearch
, would not be possible without your multi-year investment together with
@TheMarkFdn
.
@NatureMedicine
🔗
0
9
37
It is my absolute pleasure to chair the
#AACR23
major symposium on understanding & intercepting mechanisms of drug resistance, will present new data on IO & PARPi resistance together with
@GShapiroMDPhD
@DanaFarber
& Tim Yap
@MDAndersonNews
@hopkinskimmel
2
3
36
Persistent mutations-clinical version:There is more to TMB than just a number. There is more to targeted NGS than mutations in driver genes, integration of sequence & structural alterations detect "hard to lose" mutations that drive IO response
#OpenAccess
1
10
35
Excited to present our
#liquidbiopsy
informed
#Clinicaltrial
as a featured poster at
#WCLC2021
! This trial leverages
#ctDNA
#research
from
@HopkinsThoracic
and
@MolecularOncLab
, is led by
@CDNCancerTrials
and sponsored by
@CancerResearch
and the
@TheMarkFdn
.
@hopkinskimmel
@IASLC
1
11
36
Just arrived at
#AACR23
, excited to be immersed in ground breaking research for the next 4 days! Stop by the
@MolecularOncLab
@HopkinsThoracic
sessions and posters!
@Blair_Landon15
@JennaCanzoniero
@hopkinskimmel
#AACR23
,
@MolecularOncLab
#1
/7:
@CMM_JHU
student extraordinaire
@Blair_Landon15
will present her work on ctDNA analyses in predicting tumor regression with neoadjuvant immuno-chemotherapy for patients with operable esophagogastric cancer.
@hopkinskimmel
@HopkinsThoracic
0
6
15
1
5
36
📢
#countdown
to 2023 with a
#YearInReview
from
@MolecularOncLab
and
@Hopkins_MTB
, stay tuned for new studies on
#genomics
and
#liquidbiopsies
for
#cancer
#Immunotherapy
coming out in
#January2023
!
@hopkinskimmel
#1
KRAS genomic landscape
@CCR_AACR
1
12
34
#ChristmasEveEve
with homemade
#Greek
kataifi (while baking I fell asleep for 2 hrs while putting the kids to sleep-turning out to be the secret ingredient :) :) ).
#MerryChristmas
It’s starting to look a lot like Christmas 🎄
Happy holidays to the Twitterverse
0
0
33
2
2
34
Proud to introduce the
@jitcancer
Special Series in Liquid Biopsies; together with
@md_stewart
& a phenomenal editorial team we have been working for over a year to put together a state-of-the-art series to discuss LB biology, technology, clinical utility and applications.
#Thread
1
17
33
Gathering nasal swabs, RNAase free H2O, sterile tubes from the
@MolecularOncLab
and
#cancergenomicslab
tonight to support the JH COVID-19 testing lab.
@MarkYarchoan
@jaffeejaffee
#COVID19
1
1
33
Wanted to thank all of the phenomenal scientists, clinicians & patient advocates as well as the
@jitcancer
editorial team that worked with
@md_stewart
and me for over a year to deliver this special series on
#liquidbiopsies
@hopkinskimmel
@CancerResrch
Looking for a
#liquidbiopsy
read for the weekend? The
@jitcancer
special series, covering CTCs, cfDNA biology, existing & emerging technologies, applications in early detection, MRD & IO response monitoring, is now complete!
Visit the journal's homepage or
0
26
63
2
13
34
Always a bitter-sweet moment when saying goodbye to
@MolecularOncLab
members, but super-proud to see them embark in their next adventure in their career!
Congrats
@MariaFatteh
for getting into
@OslerResidency
@HopkinsMedicine
& Nisha for getting into
@EVMSedu
! We will miss you!
1
4
34
Wonderful collaboration between
@Hopkins_MTB
⭐️faculty & fellows, asking the tough question of❓therapeutic inefficacy despite the presence of molecular targets in
#Glioblastoma
.
👏
@PaolaGhanem
@MariaFatteh
D Kamson
@Karisa_Schreck
for leading this effort!
0
12
33
Lovely way to end a
#science
packed day at
#AACR23
with an all-star
#WomenInScience
@MolecularOncLab
dinner!
@JennaCanzoniero
@Blair_Landon15
@archana__balan
@LavanyaSivapal1
@HopkinsThoracic
@AACR
So great to see the old crew of the cancer genomics
@velculescu
lab at
#AACR23
!
@AleLealMD
Jill Phallen
@dlhallberg
Dimitris Mathios
@HopkinsThoracic
@hopkinskimmel
1
5
21
1
3
33
Extraordinary presentation by
@JennaCanzoniero
on her
#cuttingedge
#research
on
#liquidbiopsies
and her vision of non-invasive
#biomarker
driven
#PrecisionMedicine
for patients with
#cancer
.
@JHBreastGyn
@Hopkins_HemOnc
@hopkinskimmel
@VeredStearns
#proudmentor
1
10
32
Here's the latest from
@MolecularOncLab
@HopkinsThoracic
led by
@SusanScottMD
and Melody Shao on differential immunogenomic features of
#immunotherapy
response in
#women
.
@FrontOncology
Read here:
@DrJNaidoo
@FordePatrick
@Hopkins_HemOnc
@hopkinskimmel
1
17
33
Phenomenal
#liquidbiopsy
meeting, thanks
@isliquidbiopsy
for bringing together thought leaders from around the world for 3 days of great presentations and thought-provoking discussions!
@ChristianRolfo
@UmbertoMalapel1
@drgandara
@ElJanLe
@MCristofanill
@MJOSESERRANO19
#ISLB22
1
6
33
Here's our latest, hot off the press in
@CCR_AACR
,
@HopkinsThoracic
@MolecularOncLab
collaborative effort led by star
#scientists
@LavanyaSivapal1
&
@josephcmurray
, another brick in the
#ctDNA
wall of
#immunotherapy
response.
@hopkinskimmel
Online first
0
11
31
Incredibly thankful to
@CancerResearch
and
@TheMarkFdn
for their tremendous support in launching our
#ctDNA
interventional IO trial in
#NSCLC
. Time for the next gen of molecular response adaptive clinical trials!
@hopkinskimmel
@HopkinsThoracic
@CDNCancerTrials
Excited to announce today our partnership with
@CancerResearch
and
@ValsamoA
of
@hopkinskimmel
to advance advance ctDNA as a marker of therapeutic response.
#Clinicaltrial
0
3
16
1
7
32
Thanks
@hopkinskimmel
for featuring the BR36
@CDNCancerTrials
#ctDNA
clinical trial just published in
@NatureMedicine
in the Kimmel newsroom!
@CancerResearch
@HopkinsThoracic
@MolecularOncLab
0
10
32
We just reviewed our 💯th case at the Molecular Tumor Board
@hopkinskimmel
! Thanks to all the invaluable contributions from
@JHBreastGyn
, neuro-onc,
@HopkinsThoracic
,
@JHUPath
, our genomic counselors and computational biologists and importantly our stellar fellows
@Hopkins_HemOnc
0
12
30
Thoughtful
#mediarelease
by
@GenomeWeb
featuring our
#liquidbiopsy
#clinicaltrial
in
@NatureMedicine
& the special review series in
@jitcancer
that we put together with
@CancerResrch
.
All 1⃣1⃣ articles are
#OpenAccess
, links below
Study Shows Utility of ctDNA Dynamics as Early Therapy Response Endpoint. A study by researchers at Johns Hopkins and the Canadian Cancer Trials Group demonstrated that early molecular therapy response correlated well with radiographic findings.
0
5
9
0
13
32
The
@MolecularOncLab
is on the way to
#AACR24
! Hope to see everyone at our presentations & poster sessions covering
#liquidbiopsies
#cancergenomics
,
#Immunotherapy
#PrecisionOncology
! + celebrating 3⃣ scholar-in-training awards!
@AACR
@Blair_Landon15
@LavanyaSivapal1
@MariaFatteh
0
14
32
Honored to receive a Johns Hopkins Catalyst Award, thank you
@deniswirtz
for the support!
#liquidbiopsies
#precisionimmunooncology
@MolecularOncLab
@HopkinsThoracic
@hopkinskimmel
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Thank you
@NatureCancer
for highlighting our work! Incredibly fortunate to mentor a diverse group of
#womenandgirlsinscience
at
@MolecularOncLab
and Molecular Tumor Board
@hopkinskimmel
and being mentored by incredible
#WomenInScience
@JulieBrahmer
@DinaTiniakos
@KarchinRachel
🌟"Multimodal genomic features predict outcome of immune checkpoint blockade in non-small-cell lung cancer" by
@valsamoA
&Co
@NatureCancer
Find it at:
#11F
#WomenInScience
#WomenAndGirlsInScience
@UN_Women
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Critical
@CancerResrch
collaborative effort across
#Academia
#pharma
and
@FDAOncology
on
#ctDNA
dynamics for response monitoring during
#immunotherapy
just published in
@JCOPO_ASCO
.
Read here:
#CTMoniTR
#WhatFriendsDoes
#ctDNAFriends
#LCSM
@hopkinskimmel
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Proud of our
@MolecularOncLab
member
@PaolaGhanem
for her book chapter in “Cancer Immunotherapy Principles and Practice” with
@JulieBrahmer
! This is a seminal book for
#cancer
#immunotherapy
#booklovers
.
@HopkinsThoracic
@sitcancer
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Here’s our latest, just out in
@NatMachIntell
: meet bigMHC an ensemble
#neuralnetwork
that transfer learned neoantigen immunogenicity! Experimental validation remains the holy grail, but is this feasible &scalable? Rhetoric question 😊. Read
@KarchinRachel
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Here’s the
@MolecularOncLab
computational team seeing the paper go live! Archana Balan
@Blair_Landon15
James White
@Marta_M_Agrawal
@PaolaGhanem
Chris Cherry
@HopkinsThoracic
@CMM_JHU
@JHSPHBMB
@OslerResidency
congrats on your phenomenal work! Until the next one 😉!
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👏Congratulations to our star
@MolecularOncLab
@JHBreastGyn
fellow
@JennaCanzoniero
for receiving a Pearl M. Stetler Fellowship Award to study
#breastcancer
clonal evolution via
#liquidbiopsy
approaches!
@Hopkins_HemOnc
@HopkinsThoracic
@VeredStearns
#PersonalizedMentoring
#bcsm
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New paper alert in the
@jitcancer
Special Review Series on Liquid Biopsies led by
@FDAOncology
@PazVellanki
@harpreet_md
@realrickpazdur
@DrJuliaBeaver
, discussing the regulatory implications of liquid biopsies.
Read article here:
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Consider joining the
@MolecularOncLab
at
@HopkinsThoracic
! We are recruiting for a
#postdoc
(Scholarship in Liquid Biopsies track) & a
#research
tech position; looking for folks that are passionate about
#cancer
#genomics
&
#liquidbiopsies
! DM or apply at
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Honored to present the first stage of theBR36 ctDNA molecular adaptive clinical trial at the
@CDNCancerTrials
plenary tonight! Thankful to all patients and BR36 investigators!
@HopkinsThoracic
@CancerResearch
#CCTG2024
welcomes Dr. Anagnostou
@ValsamoA
presenting on BR36 stage 1 results at the network plenary session.
#solvingcancertogether
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29
Great
#Spotlight
commentary on our
@NatureMedicine
article on persistent mutations, a biologically distinct subset of the overall tumor mutation burden that drive sustained immunologic tumor control in the context of
#immunotherapy
@HopkinsThoracic
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Countdown to
#ISLB23
! Cannot wait to re-connect with hundreds of
#liquidbiopsy
enthusiasts in Madrid in couple days! Whether you are joining in person or through on-demand access
@isliquidbiopsy
has put together a terrific scientific program👏.
Learn more:
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10
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Gratified to present the results of the first stage of BR.36
#ctDNA
molecular response adaptive
#immunotherapy
clinical trial at
@hopkinskimmel
, together with
@josephcmurray
&
@LavanyaSivapal1
's soon-to-be-published study on heterogeneity of IO response .
Join us in the
@hopkinskimmel
series of cutting edge
#Technology
featuring
#liquid
biopsies this week.
@josephcmurray
& myself will be discussing 2 new studies on
#liquidbiosies
from
@HopkinsThoracic
coming out soon & bridging scientific discovery with clinical
#Cancer
care.
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Great to see the wealth and breadth of the
@hopkinskimmel
young investigators presenting their work today!
@michaelconroy
@MariaFatteh
@mimi_najjar
@Blair_Landon15
@LavanyaSivapal1
@archana__balan
@HopkinsThoracic
@MolecularOncLab
@Hopkins_MTB
Join us for
@hopkinskimmel
Trainee Research Day on April 24, 2024! The
@MolecularOncLab
@Hopkins_MTB
young investigators will be showcasing their work at the FAMRI Plaza Courtyard outside CRB II.
Stop by & learn about
#liquidbiopsies
#cancergenomics
#immunotherapy
#biomarkers
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#proudmentor
of Justin Huang, who masterfully presented his findings on T cell repertoire reshaping and priming of new T cell responses with radiation and immune checkpoint blockade for patients with NSCLC low on PDL1 or TMB, a population that we urgently need new tx strategies.
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Looking forward to the
@CancerResrch
#ctDNA
meeting this week, key updates on the
#ctMoniTR
project & critical discussions to bring
#liquidbiopsies
to the forefront of clinical decision making.
Register here:
#ctDNAFriends
@FDAOncology
@hopkinskimmel
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10
29
Cannot think of a more forward-thinking, kind and supportive group of
#WomenInMedicine
#WomenInScience
! Fortunate to be part of this group.
#InternationalWomensDay
@hopkinskimmel
@MolecularOncLab
@HopkinsThoracic
@Hopkins_MTB
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Wonderful to see
@LavanyaSivapal1
featured in the C3PO
@HopkinsMedicine
post-doctoral series! Congrats for a phenomenal talk on dissecting immunotherapy response by liquid biopsies!
@hopkinskimmel
@JHPDA
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Congrats to our
@MolecularOncLab
@HopkinsThoracic
star
#postdoc
fellow
@LavanyaSivapal1
for her International Lung Cancer Foundation
@IASLC
Fellowship Award to study clonal evolution of
#lungcancer
in the context of neoadjuvant
#immunotherapy
!
@hopkinskimmel
@JHPDA
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Here's the newest from
@HopkinsThoracic
:
👉
#cfDNA
fragmentation &
#lungcancer
detection
@NatureComms
👉Single-cell MANA-reactive TIL profiles
@nature
👉Clinical & genomic analyses of PrE0505
@NatureMedicine
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9
27
What a surplus of
#talent
,
#CuttingEdge
science and
#clinical
#research
at the
@hopkinskimmel
@Hopkins_HemOnc
2nd yr
#Fellows
#research
exchange! Congrats to everyone, truly inspiring work especially during a very challenging year.
@kamarrone
@redcell_doc
M Armanios
#ProudMentor
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[1/🔢] Just published in
@CellRepMed
our new collaborative integrative
#genomics
effort in IO treated
#melanoma
with
@hopkinskimmel
@bloombergkimmel
@UCLAJCCC
team
@velcu
@Pardol
Suzanne Topalian
@KarchinRachel
@AACRPres
Catie Grasso
4
10
27
Thanks
@RielyMD
for chairing an awesome session on cutting edge analyses leveraging
#AACRGENIE
data at
#AACR20
. Our
#AACR_GENIE_KRAS
team reported tumor-dependent Ras prevalence estimates and co-mutation patterns based on Bayesian modeling by
#RobScharpf
@hopkinskimmel
#1
/4
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Thank you
@CellRepMed
for featuring our work on
#Melanoma
#Genomics
and integrative
#transcriptomic
analyses! Understanding the molecular nuances of
#cancer
enables
#PrecisionOncology
.
@HopkinsThoracic
@hopkinskimmel
@bloombergkimmel
@MolecularOncLab
Our colleague Yixin chose to pay tribute to the advances we've published in
#cancergenomics
and
#multiomics
with a paper
@ValsamoA
et al. We'd like to say thank you to all of our authors, advisory board members, reviewers, and readers for driving science and society forward!
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