🎉🎉🧠🧠🔬🔬🥼🥼🧬🧬.Big day! New @AmarSahay_ lab #preprint! Please share! Feedback welcome!.🍫🍫🍩🍩🍦🍦🔥🔥. Here we identify a unique cell-type and circuit in the brain 🧠 that regulates context-dependent feeding! 🍫🍫🍫. 🧵… 1/9.

Hi @UW.

Distance medley. 5K. 10K. Half. @BAA

❤️

Not sure how to put into words, but after more than 14 wonderful years together, I had to say goodbye this week to my beloved dog, Luna. She was a rescue, my first and only dog, and she was so kind and sweet. I am devastated, but I am grateful to have shared life with her.

Also: if anyone’s hiring faculty, I’d love to chat anytime (…and you will probably get my job app soon anyway, if you haven’t already). Perhaps I’d be a good fit!

Unfortunately, I have to keep my #sfn2024 trip a little short this year (my senior dog needs extra care). Sorry to miss this lateral septum session, but everyone should go (and all their posters)! 🔥🔥🔥

Fun fact! I’ll be at #sfn2024 this year! Let’s hang out and please come check out my poster/ongoing work this Monday PM! Hippocampus! Lateral septum! Hypothalamus! 🧠🧠🧠

RT @AmarSahay_: Excited for these 3 accomplished and kind scientists to go on the faculty job market this fall and share their exciting pro….

RT @HypothalamusGrc: Check out this amazing community! 🤩 A heartfelt thanks to all of you for making this such a special meeting! See yo….

RT @AmarSahay_: Annual Lab summer dinner at one of our fav places. Celebrating recent, current and imminent milestones with laughs, life an….

Bonus post: for more on the diverse contributions of the #hippocampus to #memory and #aging, check out our other recent #preprint!:.

RT @biorxiv_neursci: An aging-sensitive compensatory secretory phospholipase that confers neuroprotection and cognitive resilience https:/….

RT @biorxiv_neursci: A dorsal hippocampus-prodynorphinergic dorsolateral septum-to-lateral hypothalamus circuit mediates contextual gating….

Finally, if the dissection of neural circuits for regulation of #hippocampus- and #context-dependent behaviors sounds as cool/important as I think it is, please consider me for a faculty position! . Thanks!. End/9.

This work was inspired by many, many stellar groups! ⭐️⭐️⭐️. As always, so many thanks to our brilliant team/collaborators!: @Jason_Alipio @AntoineBesnard_ @ain_chung @xinduan @AmarSahay_ . And funding!: @NIMHgov @BBRFoundation @harvardbrainsci . 8/9

TL/DR: This work highlights how specific 🧠 circuits of the #hippocampus, #septum, and #hypothalamus may gate #eating when #context is important. 🍫🍫. One may consider how these systems may become dysfunctional when eating (or motivation more broadly) is perturbed. 7/9.

…4) Activation of DLS(Pdyn) neurons reduces feeding and triggers spatial avoidance🛑. 5) Animals can be trained to food-seek in a specific context… and this effect appears lost with inhibition of DHPC-DLS or DLS(Pdyn)-LHA circuitry, or even Pdyn itself in the DLS!🧁. 6/9

Some favorite findings:. 1) Prodynorphin (Pdyn) cells are distinct from other neuropeptides in the LS🔬. 2) DLS(Pdyn) cells are similar in females/males🐁, and appear conserved in humans . 3) DLS(Pdyn) cells receive dense DHPC input, and inhibit GABA cells in the LHA🔥. And… 5/9

Using extensive mapping of septal neuropeptides + rigorous circuit dissection and behavior🐁, we identify #prodynorphin cells in the dorsolateral septum (DLS) as a critical bridge between the dorsal #hippocampus (DHPC) and lateral #hypothalamus (LHA) for contextual feeding!. 4/9

The #hippocampus (HPC) is essential for contextual memory… likewise, the #hypothalamus (see: @HypothalamusGrc) critically regulates food-seeking. But what circuits might bridge these regions for calibration of feeding when #context matters?. 3/9.