Thomas Piers
@Thomaspiers
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Lecturer in Neuroscience and Translational Research Fellow interested in how disease risk affects microglial activation states #AD #iPSC #Epigenome
Exeter, England
Joined September 2010
Excited by microglia, drug discovery and the power of stem cell models? Come to beautiful Devon for a fully funded PhD with myself and @PsyEpigenetics. @ExeterBRC @uniofexeHLS @ExeterMed @ExeterNeuro. Application deadline 24th June 2024: https://t.co/C4PZhiKTul
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Excited to start as Emerging Leader at @UKDRI and continue to study cellular crosstalk in neurodegeneration
We're delighted to announce 3 new UK DRI Emerging Leaders: @M_Malpetti, @AnnaMallach, & @val_jaramillo! š š š The initiative supports exceptional ECRs on their journey to setting up an independent lab. Find out more about our new Emerging Leadersš https://t.co/MhBSQf0tdn
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No, not šÆ Elon. In the U.K. theyāre not going round āfinding people whoāve said something they disagree with and putting them in a fāking cage.ā Some people are being charged for inciting racial hatred and for organising acts of violence. Itās very specific, and itās the law in
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Dr @Thomaspiers at the @UniofExeter is developing a brain organoid model containing human neurons and microglia (the immune cells of the brain) to study the early stages of Alzheimerās disease. #kinderscience #dementiaresearch #alzheimersdisease
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Really excited about the opportunity to direct the UK Human Functional Genomics Initiative! Please do get in touch if you are interested in learning more about our plans and joining the community https://t.co/hlY8JIfcPB
@UniofExeter @UKRI_News @The_MRC
forms.office.com
Weāre funding four research clusters and welcoming Director Prof Jonathan Mill @UniofExeter to lead the Human Functional Genomics Initiative. The Ā£28.5m initiative will advance our understanding of how genomic variation influences human physiology: https://t.co/YtBvw85nxX
@BBSRC
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TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism https://t.co/Rcze36Dn92
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PhD Studentship at University of Exeter @UniofExeter: Deciphering Cell-type Specific Effects of P2X7R Antagonism in Lewy Body Dementia. Closing date: 12th August. #PhDPosition. https://t.co/4qP0vPC7Xx
dementiaresearcher.nihr.ac.uk
PhD Studentship at University of Exeter: Deciphering Cell-type Specific Effects of P2X7R Antagonism in Lewy Body Dementia. Closing date: 12th August.
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I have an exciting PhD position available to join my lab starting this October at the @UKDRI . If you are interested in understanding how microglia contribute to Parkinson's disease and want to study cellular interactions using different methods, apply!
findaphd.com
PhD Project - Using machine learning to predict cell-type specific effects of genetic variants which influence genome regulation at Imperial College London, listed on FindAPhD.com
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Positive Ultra-bright Fluorescent Fusion For Identifying Neighbours (PUFFFIN) allows visualization and isolation of surrounding cells in culture, tissues, or embryos, for profiling non-cell-autonomous responses @_CellySally_ et al https://t.co/CoefaolcCt
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What an evening in North Cornwallš. Imagine working somewhere with this on your doorstep. @uniofexeHLS currently recruiting for genomics and data science faculty posts. https://t.co/4pacwbqnIJ. Please RT.
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Last few days to apply for this exciting PhD studentship for those interested in human disease modelling using iPSC-derived organoids with @PsyEpigenetics and me. @ExeterBRC @uniofexeHLS @ExeterMed @ExeterNeuro Application deadline 24th June 2024:
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Weāre proud to launch the #DementiaCoalition Manifesto alongside our partners at @UKDRI, @alzheimerssoc, @DementiaUK & @alzscot. As our population ages, dementia will be the defining health challenge of our time. The next Government must act. https://t.co/f7HeZvNAM4
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New preprint by @eilis_hannon showing how DNAm data from long-read seq (@nanopore) can be used to assign individual reads to specific cell-types - provides a computational method for generating cell-specific DNAm profiles for epigenetic epidemiology.
biorxiv.org
DNA methylation differs across tissue- and cell-types with important implications for the analysis of disease-associated differences in tissues such as blood. To uncover the biological processes...
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We have a funded 3.5 year PhD studentship exploring genomic mechanisms underlying resilient and susceptible neurons to tangle pathology in AD brain. Come work in the @Dementia_Omics team at @uniofexeHLS with myself, @Jenny_Imm and Adam Smith! Check it out:
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It is so exciting to see my postdoc paper (finally) out! https://t.co/nZPwonYj5L Here we tested novel spatial transcriptomics platforms to investigate how cells interact in a model of Alzheimer's disease. We found... 1/n
cell.com
Mallach etĀ al. resolve the local environment around amyloid pathology in mice. Next to microglia, astrocytes emerge as a key signaling partner in this disease environment, interacting with both...
Researchers at the UK DRI, @TheCrick & @CBD_VIB led by @AnnaMallach & @Arancibia_Lor have found that communication between support cells in the brain is closely linked to Alzheimerās in miceš§ The findings could lead to new therapeutic targetsš https://t.co/MHK0roKy3H
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Super exciting to see my paper so widely discussed at the @TheCrick - it was great working with the core facilities to get early access to these incredible technologies
Researchers at the Crick, @UKDRI and @CBD_VIB have found that chatter between support cells in the brain is closely linked to Alzheimerās disease in mice. The findings open up potential research avenues in the search for new Alzheimerās treatments. https://t.co/NoNImb9jKd
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Happy to share our peer-reviewed paper on human hypoblast :) Our naĆÆve stem cell based models capture the ICM to hypoblast specification trajectory in the human blastocyst, and reveal a critical role for FGF in this path. https://t.co/deqLaDCr71
cell.com
In this study, Guo and colleagues report differentiation of human naive pluripotent stem cells into extraembryonic hypoblasts. They show that inĀ vitro differentiation captures the transcriptome...
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Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimerās disease mouse model, as revealed by spatial transcriptomics: @CellReports
https://t.co/XTzPQknW0k
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1/6 š§¬ Exciting news in #RNAregulation! Our new study, "ePRINT: exonuclease assisted mapping of protein-RNA interactions," is now published in @GenomeBiology. Dive into the full text here:
link.springer.com
Genome Biology - RNA-binding proteins (RBPs) regulate key aspects of RNA processing including alternative splicing, mRNA degradation and localization by physically binding RNA molecules. Current...
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Very excited to be joining @ImperialBrains as an Edmond Safra Fellow in July š„³š§ š§Ŗ Come and join me on this fun adventure with a 3.5year fully-funded PhD investigating microglia in Parkinson's. Deadline is the 17th of June https://t.co/k9il9Rd6zu
findaphd.com
PhD Project - Using machine learning to predict cell-type specific effects of genetic variants which influence genome regulation at Imperial College London, listed on FindAPhD.com
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