RT @ModernPathology: In traumatic neuromas, the individual nerve packets are each cuffed by perineurium. A vintage Mod Pathol study demonst….

RT @ModernPathology: Another Modern Pathology classic - Miettinen M, Sarlomo-Rikala M, Sobin LH. Mesenchymal tumors of muscularis mucosae o….

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It typically presents in older adults and is part of the differential encountered during workup of cytopenias. CD56, which is expressed on normal/non-neoplastic NK cells, is negative in up to half of cases.

Diagnosis: NK-large granular lymphocytic leukemia, also known as chronic lymphoproliferative disorder of NK cells. While most patients are asymptomatic, NK-large granular lymphyocyticleukemia (chronic lymphoproliferative disorder of NK cells) can cause neutropenia and anemia.

Molecular: STAT3 p.D661V pathogenic activating mutation at 28% VAF.

Flow cytometry: The population of interest is in black. Normal background lymphocytes are in green. Flow cytometry shows 75% of lymphocytes to be NK cells with expression of CD2, CD7, and CD16, with loss of CD56 expression and absent KIR isoform expression (not shown).

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History: •75 year old presenting with cytopenias. WBC 7.9 with absolute lymphocytosis of 6.2 10*3/uL and neutropenia of 0.9 10*3/uL, normocytic anemia at 9.5g/dL, and normal platelets. Peripheral blood morphology:

Here's a case from Dr. Philipp W. Raess from our upcoming Challenges in Hematopathology course: See thread for history, images, discussion. #PathX #PathTwitter.

RT @ModernPathology: This pancreatic ductal adenocarcinoma spread to the ovary despite negative frozen section margins! Well, duh, the two….

RT @ModernPathology: Serotonin-producing pancreatic neuroendocrine tumors have a peculiar sclerotic background that is a clue to the diagno….

Discussion (4): and some cases of primary cutaneous gamma-delta T-cell lymphoma.

Discussion (3): Clinical-pathological correlation is essential in order todifferentiate from other epidermotropic cytotoxic T-cell lymphomas that exhibit much more aggressive behavior, principally primary cutaneous CD8 positive aggressive epidermotropic cytotoxic T-cell lymphoma.

Discussion (2): CD8 positive MF is associated with young age and early stage at presentation. It has a favorable prognosis with a higher rate of remission and lower rate of progression than unselected cases of MF.

Diagnosis: Mycosis Fungoides (CD8-positive). Discussion (1): Neoplastic lymphocytes in the majority of mycosis fungoides (MF) cases are CD4 positive. However, in a proportion of cases, such as the one shown here, the T-cells express CD8 rather than CD4.

Histology: Epidermotropic infiltrate of CD8 positive T-cells.

Dr. John R. Goodlad shared this case which he'll be presenting at our October Hematopathology course in Palm Springs: Male aged 12 years, presented with hypopigmented patches on back. #PathX #PathTwitter

Celebrate Excellence. Elevate Pathology. Each year, USCAP honors pathologists who advance our profession through groundbreaking research, impactful publications, and dedicated service. Apply or nominate someone for Honors by 10/22. Find out more:.

Not to nag. but have you started writing up your abstracts yet? This article by @RhondaYantiss might be helpful:

RT @LIjournal: Our August 2025 (Volume 105, Issue 8) is available online!

RT @ModernPathology: Classic pleomorphic adenoma; modern techniques buttress and expand upon what we have learned on good old hematoxylin a….