Foo Lab
@TheFooLab
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Heart failure Epigenomics and Molecular Epigenetics Laboratory // Genome Institute of Singapore @astar_research, Cardiovascular Research Institute @NUSingapore
Singapore
Joined June 2018
RT @junedh_amrute: We discover RUNX1 as a nodal regulator of human cardiac recovery and uncover a druggable epigenetic mechanism in macroph….
biorxiv.org
Despite advances in disease treatment, our understanding of how damaged organs recover and the mechanisms governing this process remain poorly defined. Here, we mapped the transcriptional and...
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RT @rsyf2: Our Spatial Transcriptomics study of human #aortic full thickness punches shows smooth muscle cell clusters in early atheroscler….
biorxiv.org
Vascular smooth muscle cells (VSMCs) contribute dynamically to atherosclerosis at all stages but the molecular drivers of their phenotypic switching, especially during early plaque development, and...
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RT @rsyf2: Organs don't work in silos !! It's time to track outcomes across the disease specialities, when they are so much metabolism driv….
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RT @junedh_amrute: We use CITE-seq, Xenium, human PET imaging, and in vivo lineage tracing to identify FAP as a marker of modulated SMCs in….
biorxiv.org
Vascular smooth muscle cell (VSMC) and immune cell diversification play a central role in driving atherosclerotic coronary artery disease (CAD)[1][1]–[3][2]. However, the molecular mechanisms...
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RT @heshamasadek: Open faculty positions announcement: 2 advanced HF faculty positions are available at The University of Arizona. All facu….
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RT @rsyf2: None of this team entered science to make a high salary. Several could well have a luxury life doing something else. So each tim….
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RT @rsyf2: The wonderful joys of hanging out with younger people. and learning from them about their aspirations and big dreams @TheFooLab….
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RT @rsyf2: Grateful for the plug for RESET. We are still on a drive to enrol participants. free scans and tests, and a 5yr long follow….
medicine.nus.edu.sg
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RT @CircAHA: #ICYMI: Asns marks cardiomyocyte dedifferentiation @yike_zhu @TheFooLab @NUSingapore @NUSMedicine @chesterleedrum @zentiang @m….
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Early access link below ! :.
ahajournals.org
BACKGROUND: Cardiomyocyte differentiation involves a stepwise clearance of repressors and fate-restricting regulators through the modulation of BMP (bone morphogenic protein)/Wnt-signaling pathways....
We've found that the cell adherens junction is crucial for cardiomyocyte development through the NF2-YAP-AMOT protein complex @NUSMedicine @NUSResearch @CvdNus @TheFooLab @Meekelee
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So much good science and fun with old and new friends at #KSCardioEpi24 Hannover Harrenhausen palace. Till we meet again !. #Cardiovascular #Epigenetics #GeneRegulation
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Explore emerging #Cardiomyopathy #Transcriptomics #cardiomyocytes research with field leaders @KeystoneSymp Cardiovascular Epigenetics and Gene Regulation, this April in Hannover! #KSCardioEpi24 . Catch the discounted reg rates before valentines day !
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Our first manuscript in 2024 published on @eLife Human genomic safe harbours, transgene shutdowns no more !.
elifesciences.org
Depiction of novel human genomic safe harbour loci that have been validated in vitro for safety and stable expression in human embryonic stem cells and cell types from all the three germ lineages.
Happy to share that our (@TheFooLab @astar_gis @CvdNus) manuscript on human genomic safe harbours validated in hES and differentiated cells is now published in @eLife . 1/n.
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Fun moments this afternoon as the Cardiovascular Programme got together ahead of Christmas. Lucky draw, cash vouchers, ice cream cart, popcorn, photo booth, Santa dressing up. Hilarity all round. Amazing year at @NUSMedicine @NUSResearch @CvdNus
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Year end lab meeting !. Featuring:.Santa claus and the red nose reindeer ?
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Public outreach at the stan chart marathon !. #preventivecardiology #cvmdtrp #nusmed #bringingcardiologytopeople.
Med students doing what they love. Spreading the news about #HeartHealth . We've been at the #singaporemarathon @SG_marathon . Runners and their families want to know about their hearts and health @NUSResearch @NUSMedicine @CvdNus @TheFooLab
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RT @rsyf2: last week we were richly treated to a big CV giant speak to us about the myths of cardiac stem cell . there is too much fraud….
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RT @stemcellpodcast: We have a new episode out!. Dr. Roger Foo (@rsyf2) from @NUSingapore joins us to discuss his work studying the genetic….
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