TheFischerLab
@TheFischerLab
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Interested in adding a splash of water to your ligand discovery campaign? Check out our latest article:
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A GUI that seamlessly integrates FLEXR electron density based multi-conformer model building into Coot1's modeling and validation tools.
journals.iucr.org
This article describes a graphical user interface (GUI) for the multi-conformer modeling program FLEXR, designed as a plugin within Coot 1. At the click of a button, the GUI allows seamless integra...
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Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines. Exemplifies the power of collaboration at @StJudeResearch by CBT Chemistry Centers, @KlcoLab and @TheFischerLab funded by @AlexsLemonade.
nature.com
Nature Communications - Here, the authors describe a potent and selective CK1a molecular glue degrader with a broad antiproliferative potency. Crystallographic data provide rationale for the high...
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The opus magnum of our PhD student Fatemeh, now @KymeraTx, is out in @BloodJournal in collaboration with the @CMullighan lab: The orally bioavailable GSPT1/2 degrader SJ6986 exhibits in vivo efficacy in acute lymphoblastic leukemia.
ashpublications.org
Key Points. SJ6986 is an orally available GSPT1/2-degrading molecular glue that potently suppresses lymphoblastic leukemia cell proliferation in vivo.CRISP
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RT @AnsariLab: We're at it again, but even better! Please join us virtually or in person at St. Jude for 2023 Bringing Chemistry to Medici….
stjude.org
This symposium features thought leaders at the interface of chemical and biomedical sciences, working in areas spanning therapeutic regulation of transcription and chromatin, computational biology,...
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RT @StJudeResearch: Like comparing apples to apples, comparing similar proteins can be challenging. Scientists in @TheFischerLab developed….
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RT @ActaCrystD: FLEXR uses Ringer-based electron-density sampling to build explicit multi-conformer models for refinement, capturing confor….
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Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B
elifesciences.org
Many small-molecule fragments bind differently to the allosteric protein PTP1B in room-temperature instead of cryogenic crystal structures, which may be relevant for structure-based drug design.
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RT @rinikerlab: Interested in water in ligand binding sites? Our newest paper applies RE-EDS to study the thermodynamics of water networks….
pubs.acs.org
Macromolecular recognition and ligand binding are at the core of biological function and drug discovery efforts. Water molecules play a significant role in mediating the protein–ligand interaction,...
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RT @StJudeResearch: New research from @TheFischerLab published in the Journal of Medicinal Chemistry has revealed distinct targetable hotsp….
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Thrilled to see @TheFischerLab's latest work on how "Water Networks Repopulate Protein-Ligand Interfaces With Temperature" out in @angew_chem.
onlinelibrary.wiley.com
Cryo-cooled water molecules block protein motions that impact protein–ligand interactions. Paired cryo and room-temperature comparisons of ligand-bound Hsp90α structures show that water networks and...
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Excited to see our collaborative work on the “Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia” appear as a Plenary Paper in @BloodJournal with @CMullighan and #stjuderesearch CBT Chemistry Centers.
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What's under your mask? Happy #Movember2021!.Support here: Join here:
us.movember.com
Movember, the month formerly known as November, is a moustache growing charity event held during November each year that raises funds and awareness for men's health.
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RT @behnamnabet: The Nabet lab @fredhutch is recruiting a highly motivated postdoc to join our supportive/collaborative team! Interested in….
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Phenyl-Glutarimides improve PROTAC stability. Another great collaboration with the CBT ChemistryCenters @StJudeResearch and @TheFischerLab (and many others) just appeared in @angew_chem.
onlinelibrary.wiley.com
IMiD-based PROTACs rapidly hydrolyze in commonly utilized cell media, which significantly affects their cell efficacy. We designed novel BET PROTACs based on phenyl glutarimide (PG) and showed that...
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Postdoc position in computational structural biology in @TheFischerLab available right now! Please re-tweet :).
@TheFischerLab has an available #postdocposition in computational #structuralbiology for a very cool project on #ligand discovery @blkwomencompbio @StJudeResearch #compbio #LXChemBio.
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RT @AnnaKamenik: 💥Enhanced sampling strikes again: we used aMD to see a buried apolar cavity open up to solvent, feeding this thermodynamic….
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Expanding the chemical toolbox for bromodomain PHD finger transcription factor BPTF in a fun whirlwind collaboration with @fewill26 and @TheFischerLab.
pubs.acs.org
The nucleosome remodeling factor (NURF) alters chromatin accessibility through interactions with its largest subunit,the bromodomain PHD finger transcription factor BPTF. BPTF is overexpressed in...
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Thanks to RSC @ChemistryWorld for a *cool* feature of our recent @ChemicalScience article
New research suggests that sampling only at cryogenic temperatures could be making things murky for structural data, leading to irritating cryo-artifacts.
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RT @ChemicalScience: 🎉 Issue 34 is here! 🎉 Marcus Fischer (@TheFischerLab) et al.'s recent #ChemSciPicks article is featured on the front c….
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