Tesfahun Admasu
@TessAdmasu
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Scientist @CedarsSinai @NUSingapore studying #Senescence #TILs and #BrainTumor from 🇪🇹
United States
Joined August 2012
RT @ethiobiomedhub: This week, we had an insightful discussion on the impact of fasting and caloric restriction on aging. Dr. Anteneh Mehar….
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Part 2.እርጅናን ማዘግየት ይቻላል? Can We Delay Aging? Updates on current Interventions, . via @YouTube.
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RT @ethiobiomedhub: We discussed the underlying mechanism of aging and its associated susceptibility to various chronic diseases. Thank you….
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ስለ ካንሰር በሽታ እና አዳድስ የካንሰር ጥናቶች እና ቴክኖሎጂዎች ላይ ያደረግነዉን ውይይት ተጋበዙልን። . የቆሽት ካንሰር ጥምር መድሃኒት ግኝት ላይ የተደረገ ውይይት Discovery of combination therapy f. via @YouTube.
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RT @ethiobiomedhub: Discussion on the importance of scientific platforms with Dr Birualem, Dr Dereje @Zdereje, Dr Tizibt @aferlibela https:….
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In 2000, @JeffBezos launched @blueorigin , two years later in 2002 @elonmusk launched @SpaceX . In 2022 @JeffBezos launched @altos_labs , Two years later in 2024.@elonmusk will launch …. .
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RT @jpsenescence: Great to collaborate with @TessAdmasu et al. in this study of primary and paracrine senescent cells to reveal that ferrop….
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RT @senstweet: SRF scientists have discovered that a whole class of senescent cells evades classic senolytic drugs! But a new way of target….
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RT @CellReports: Selective ablation of primary and paracrine senescent cells by targeting iron dyshomeostasis
cell.com
Admasu et al. used DPP4 to isolate and enrich paracrine SCs. They showed that paracrine SCs are resistant to previously reported senolytic drugs. They identified ferroptosis induction and ferrous...
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Proliferating cells did not have a sufficient amount of ferrous iron to break the cage, therefore, TRX-CBI conjugate remains stable and hence non-toxic. 6/6.
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We then designed a ferrous iron-activatable drug conjugate TRX-CBI. When SCs exposed to TRX-CBI, the high level of ferrous iron undergoes a Fenton reaction and breaks the cage to release the cytotoxin CBI within the cell which leads to the selective killing of SCs. 5/6.
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First, we tested if ferroptosis inducer drugs can be used as a senolytic and found that FIN56 selectively ablates both types of SCs. Due to the limitations of using ferroptosis inducers as a senolytic drug in the clinic, we look for alternative approaches. 4/6.
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To find a common senolytic target for primary and paracrine SCs, we run an RNASeq analysis and found ferroptosis and iron metabolism-related genes as top hits. We found that SCs accumulate high levels of iron, specifically the toxic form of iron called ferrous iron. 3/6.
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