
Teif Lab
@TeifLab
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Teif lab at @uni_of_essex. We work on nucleosomes, chromatin, TFbinding, CTCF, cfDNA. Find us at 🐘 and 🦋. [email protected]; [email protected]
University of Essex, UK
Joined March 2019
My first interview in a major podcast :) Quite an interesting experience! Thank you very much for inviting @epigenetics_pod.
In this episode we talked to @TeifLab from the University of Essex about his work on nucleosome positioning in #cancer #diagnsotics. #podcast #Epigenetics . Listen here:
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Very happy to contribute to this CTCF-nucleosome paper by @ElenaPugachev12 &Co. Exciting science and a cool journal cover!.
Excited to share our latest study published in Nucleic Acids Research: It’s the cover story for Issue #12! We drew inspiration from Greek mythology to illustrate CTCF’s constant struggle in shaping the 3D genome architecture.
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RT @ElenaPugachev12: Excited to share our latest study published in Nucleic Acids Research: It’s the cover story fo….
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NHS announced that it will start offering first liquid biopsy tests for diagnostics of lung and breast cancer; also planning expansion to pancreatic and gallbladder cancers
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We have a postdoctoral opening for a researcher with experience in bioinformatics of DNA sequencing and machine learning to work on the development of new methods for cancer diagnostics related to nucleosomes, chromatin and more Apply by 21st April 2025!.
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Very happy to contribute to this paper about cfDNA in SCLC, led by the team of Anish Thomas. It's already online in Genome Medicine:. Takahashi et al., Genomic alterations and transcriptional phenotypes in circulating free DNA and matched metastatic tumor
genomemedicine.biomedcentral.com
Background Profiling circulating cell-free DNA (cfDNA) has become a fundamental practice in cancer medicine, but the effectiveness of cfDNA at elucidating tumor-derived molecular features has not...
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RT @PancreaticCanUK: Early detection of #PancreaticCancer saves lives. @TeifLab @EssexLifeSci are using cutting-edge technology to measur….
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RT @isabella_ciu: 2nd time at #FOG2025 (1st time presenting!), it never disappoints!✨. Great talks, groundbreaking research and good times….
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RT @isabella_ciu: So excited for the festival and this great opportunity to present my research 😄.
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Interestingly, the BBC coverage attributed this success to NHS testing vans stationed in busy areas where any person can walk-in without referral. Probably technological genomics developments also contributed to this improvement, in any case these are set to help going forward.
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Encouraging news to start the new year: NHS reports 2.7% improvement in early cancer diagnostics in comparison to pre-pandemic levels. An estimated additional 7,000 patients diagnosed at an early stage.
Latest NHS data shows that the proportion of patients being diagnosed with cancer at an early stage in England has risen to its highest ever level. Find out more about the latest data. ➡️
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Happy New Year! 2024 was not easy, but despite many challenges we also achieved a lot. We've got grants, published papers, have new exciting findings. This would not be possible without support of friends and collaborators. Wishing you health, happiness, peace & success in 2025!
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Thank you very much @PancreaticCanUK for supporting our research! In collaboration with Andrea Mohr, Ralf Zwacka and Greg Brooke, we are developing a new generation of liquid biopsies for early cancer detection based on the analysis of cell-free DNA 🧬.
Today we are thrilled to announce that we're investing almost £1 million into two new research awards which aim to improve the early detection of #PancreaticCancer 🔬
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Interesting preprint on nucleosome spacing from cfDNA [Johnston et al., 2024] The authors refer to NRL changes 10n -> 10n-5 bp. Earlier we showed that NRL decrease in cancer is more complex & context-specific [Jacob et al., 2024]
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Hope to see some of you in Hong Kong next year! Circulating Nucleic Acids in Plasma and Serum, 14th CNAPS International Symposium. Hong Kong, December 3-5, 2025. #SNAPS2025 #cfDNA #liquidbiopsy
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RT @generegulation: some statistics about mass migration of scientists, specifically for our field: .▶️~30% of our followers created accoun….
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Dear friends, please reply if you know a neurosurgeon in Romania (or close contacts among medical doctors in Romania who may connect with neurosurgeons). This is for a medical emergency, not for academic research.
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This idea is very interesting, but did anyone try to check such hypotheses (re: HP1a) with nucleosome maps? More generally, looking for publications where NRL changes are shown for local regions enriched with certain proteins (excluding studies regarding gene bodies & TF binding).
Heterochromatin protein 1 alpha (HP1α) undergoes a monomer to dimer transition that opens and compacts live cell genome architecture ▶️Monomeric HP1a increases nucleosome spacing.▶️Dimeric HP1a decreases nucleosome spacing.▶️Conclusions based on FLIM-FRET
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