Tara Brosschot
@TaraBrosschot
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PhD👩🏻🔬 Mucosal immunology. Past: infections in the small intestines @ReynoldsLabUVic. Now: in the bladder @InstitutCochin. Also plays guitar & draws things
Canada • she/her/they
Joined May 2011
My first first-author research paper is out! It's about how deworming drugs affect bacterial burdens in the gut #coinfection. See thread for a visual summary! 🪱🐭 Thanks to all who helped #teamworm. https://t.co/DThGPe8sI1
journals.plos.org
Author summary In regions where helminth infection is common and sanitation standards are poor, people are at a high risk of exposure to bacterial pathogens. Previous work in animal models has shown...
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Having fun sharing our projects with our colleagues at the 20th anniversary of @InstitutCochin! For more photos, check out @SFaureDupuy ! A huge thank you to everyone involved in planning and execution of this internal event and the symposium (open to all) over the next two days!
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Online! A great review from superstars Léa Deltourbe (not on Twitter!) and @LiviaLMariano about our favorite subject #SABV - the influence of biological sex on diseases in the urinary tract! Written in collaboration with @dhunstad17 & Teri Hrera @WUSTLmed
https://t.co/ynRMUAzzwP
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I did the thing!!
Congratulations on your successful PhD defence, to the new DOCTOR Brosschot! @TaraBrosschot @ReynoldsLabUVic
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New article out from my lab @ReynoldsLabUVic ! About worms and short-chain fatty acids. For this one we went all GenZ influencer-style and made a 2-min vlog about the contents, check it out!
Happy Friday everyone! Here is a summary of our latest paper. Watch to the end to hear all about it (and to see a cute dog)! You can read more at https://t.co/qQMf3yvT6m @InfImmAg
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Proud to watch @TaraBrosschot present her work at #molhelm2021. Thank you to the organizers for making this meeting happen! @planapalooza @Mak_Mitreva @zamanian_ #NTD #parasitology
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I raise your microbiome with a nemabiome 😎 #ohdeer #helminthology #dnasequencing #bigdata #beautifuldata Slide by @JohnGilleard from UCalgary and @HPI_network at @Zapworms seminar series
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Another cool thing I learned: scientists can read mouse facial expressions https://t.co/IZWSeqo97u Thanks for the great talk @ChelseaMatisz
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Changes in microbiota can affect behaviour, anxiety, memory... so they say. Turns out this very real. Antibiotic treatment of mice caused a deficit in fear extinction (as seen in PTSD). Can't wait to hear which metabolite is behind this! @CChu_89
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The question "who's there" is not irrelevant, but definitely more complicated as previously assumed. As @Gutzhao postulated: bacteria work together in a 'guild' that looks different in each individual! We have to report on species level, and keep the ecology of the gut in mind.
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Really enjoyed all the microbiome talks at #cddw2021. Past the hype, seeing lots of mechanistic studies. Less focus on "who's there" and more about "what are they doing?" Metabolites, baby!
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My grandmother didn't want to get vaccinated with 'strange new mRNA stuff'. I explained it with a sketch & cooking analogy. She's now been vaccinated with the BionTech vaccine. I thought this might be useful for others who know vaccine skeptics, too. Feel free to share, use & RT:
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Heres the story of how I volunteered to be infected with 50 parasitic worms (hookworm) for a year as part of a research study. Check out this thread & follow me for more #parasite & marine biology content [t] #ScienceTwitter imgs: https://t.co/hH5YsfS0ay
https://t.co/kVurE6BbTS
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Finally, we found that once Salmonella has established in the lumen during helminth infection, deworming reduces the number of bacteria but the infection does not get completely cleared. A subset of Salmonella persists after worm expulsion.
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We also tested whether Salmonella uses tissue invasion to take advantage of a helminth-altered gut environment. This does not seem to be the case. We found Salmonella primarily in close proximity to the worm, in the lumen of the gut.
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Now, we considered a possible solution: deworming. The WHO has mass deworming programs to reduce helminth burdens in at-risk populations. We asked: does deworming resolve the high bacterial burdens that are associated with helminth infection? We tested this in mice... and it did!
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As many as 1 in 5 people worldwide have chronic helminth (=parasitic worm) infections. These people may be at high risk of acquiring bacterial infections too. Previously we have found that helminths make mice susceptible to high intestinal burdens of Salmonella.
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Head over to our blog to read the amazing post written by HPI member Tara Brosschot (@TaraBrosschot ) on "Worms against COVID-19" https://t.co/j2BkUugNEO via @wordpressdotcom
theparasiteblog.wordpress.com
By: Tara Brosschot Edited by Kyle Lesack At the Kenya Medical Research Institute (KEMRI) in Nairobi, researcher Sophie Uyoga made a remarkable discovery in the summer of 2020. She tested blood from…
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We would like to wish everyone a happy poly-day and worm wishes from the Reynolds Lab. Thank you @TaraBrosschot for the artwork!
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