A core microbiome signature as an indicator of health

Your gut microbiome is a seesaw for health! 🦠 Fiber-rich diets tip it toward Foundation Guild dominance, promoting weight control and metabolic health. Junk food fuels Pathobionts, driving obesity. #TCGScience #GutHealth

The Two Competing Guilds (TCG) Model of Core Microbiome

🎙️We interviewed Prof. Liping Zhao (@Gutzhao), Executive Editor of #Microbiome Research Reports and Fellow of the American Academy of Microbiology. 🔗 Watch the full interview: https://t.co/KmjvQbDsYK #GutHealth #Obesity #MRR #HostMicrobe

My 10 year anniversary of joining X. 还记得你何时加入 X 吗？我知道！#我的X周年纪念日

Taxa should no longer be used as entry point analytical units for microbiome datasets. Genomes should be.

🎉Huge congratulations to our Editor-in-Chief, Dr. Jizhong Zhou, on being elected to the National Academy of Sciences! This prestigious honor recognizes his outstanding contributions to Microbial Ecology. We are proud and thrilled! @theNASciences https://t.co/gznLIgxDzY

Researchers, including CIFAR's @Gutzhao, have developed a new method to identify crucial gut microbes essential for health. 🦠 This discovery could lead to precision nutrition and personalized therapies for managing diabetes, IBD and more. https://t.co/4yehz8aoIF

Immensely grateful to all experts who contributed this piece with their expertise and efforts! @nsegata @cibiocm @GiovanniCammar9 @h_sokol @fasnicar @Siew_C_Ng @Gutzhao @PaedsRH @RaesLab @HoldGeorgina @ChristianHvas @KorenLab @TheTunLab @MireiaVallesc @mcarmen_collado @epasolli

Meet Evo, the DNA-trained AI that creates genomes from scratch | Science | AAAS

The third pillar of guild-based microbiome data analysis is interaction focused perspective. Co-abundance network analysis of high quality MAGs is used to identify potential guilds

The second pillar of guild-based microbiome data analysis is database independence. Each high quality MAG is given a Universal Unique Identifier (UUID) and tracked in samples across different studies for data integration and mining.

Guild-based analysis of microbiome data has three pillars, the first is genome-specific analysis with high resolution and granularity than any taxa. High quality metagenome-assembled genomes (MAGs) are the basic features.

What kind of analytical strategy would allow you to integrate 38 different microbiome studies and identify a set of 284 genomes of core bacteria into Two Competing Guilds as an indicator of Health: the guild-based analysis!

🚨New Paper Alert🚨 Our new #microbiome research, co-led with @LiatShenhav, published today in @CellCellPress! We show that #breastfeeding "paces" gut & nasal microbiome development to prevent #asthma in the @CHILDSTUDY. #Tweetorial 🧵 https://t.co/eeHSLIdw9Q

This concept of stability of relationships as a marker of functional significance is central to understanding the microbiome as a complex adaptive system, where the resilience of microbial networks is directly linked to host health.

In essence, stability within guilds like FG and PG reflects an evolutionary adaptation, enabling the microbiome to sustain functions under environmental pressures that a less connected population could not.

Restoring and maintaining the TCG structure in the gut microbiome is therefore essential for it to function as a dynamic regulatory interface between the host and the environment.

It illustrates how dietary choices shift the balance toward either health or dysfunction, suggesting that restoring FG dominance through fiber-rich diets could recalibrate this balance, realigning it with the microbiome’s evolutionary purpose.

Thus, the stable competition between FG and PG is fundamental to the microbiome’s role as an adaptive nutrient sensor.

This imbalance exemplifies how the FG-PG competition, although adaptive, becomes maladaptive in today’s dietary landscape, where one guild is consistently favored.