Spinal cord neural recording from an awake behaving animal using Neuropixel probes !! #Neuropixel #SpinalCord #ItsNotAllAboutTheBrain 😁

Looking forward to sharing our work with the scientific community.

RT @RIKEN_CBS: Did you read RIKEN CBS's advertisement article on Nature?.If you didn't read it yet, you gotta check it out! .You'll find ou….

And a big shoutout to the best colleague and a dear friend @asli_ayaz 💕.

We had a busy few weeks! Packing our equipment at @__NERF and shipping to @RIKEN_CBS! Grateful for awesome opportunities and colleagues during the 8 years. VERY excited for new journey ahead!

Also: many thanks to @jnsorg for providing *free* childcare during the #NEURO2024!.

It’s a wrap! #NEURO2024! Very proud of @TakeokaLab members presenting our work at the poster sessions. Many thanks to everyone who stopped by! @__NERF @RIKEN_CBS

@RIKEN_CBS.

We are ready for the Annual Japanese Neuroscience Meeting to showcase our work! @CharlotteBich @PA_Suray_PhD. Waiting for our flight to Fukuoka! @__NERF

A new Ph.D. in the house! Congratulations, Dr. Lavaud @LavaudSimon 🍾🥂 What an accomplishment!. We are so proud of you. Many thanks to external examiners @GattoGraziana and @RuneWBerg 🙏 @__NERF

Looking forward to visiting King’s College!.

We have a new lab website! Thanks, @goyukiya, for making it look goooooood! 👏. We also have many exciting opportunities! Our lab at @RIKEN_CBS is hiring postdocs and PhD students! Apply now!.

It is a good time to announce that the Takeoka lab is moving to the @RIKEN_CBS and hiring postdocs, PhD students, and research staff! Please get in touch if you want to work on motor control, including spinal learning! 8/n.

@charlottebich.

Thanks to the funders @FWOVlaanderen, @WFLWorldRun, Marie Skłodowska-Curie Actions! 7/n.

We think this observation represents the experience-dependent shift in what’s essential to generate a motor behavior -naïve mice need to rely on somatosensory information to isolate rules for adapting motor output, while experienced mice engage motor output circuits directly 6/n.

We also discovered that these inhibitory neurons critical for learning were not important for “remembering” what the spinal cord had learned! Instead, a ventral inhibitory population, Renshaw cells, proved essential for recall of learned behavior. @__NERF , @RIKEN_CBS 5/n.

It was a difficult journey, but we did it! We recorded from the spinal cord while mice were actively learning and found that dorsal inhibitory neurons dampened the noisy somatosensory signals, which increased the saliency of relevant signals essential for learning. 4/n.

The idea that the spinal cord learns and remembers motor experience has been around for a century, yet the HOW was unknown. We used simple conditioning behavior and identified two inhibitory neuronal populations, each responsible for learning and recall of learned behavior. 3/n.

Here, we dissect the mechanisms of learning in the spinal cord. We combined mouse genetics, circuit manipulations, and SPINAL in vivo recordings with optotagging in behaving animals! 2/n.