St Johnston Lab
@StJohnstonLab
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A cell and developmental biology lab studying cell polarity @GurdonInstitute @Cambridge_Uni | Tweets by lab members
Cambridge, United Kingdom
Joined September 2020
The Shot CH1 domain recognises a distinct form of F-actin during Drosophila oocyte determination Read this Research Report from Dmitry Nashchekin @DNashchekin, Iolo Squires, Andreas Prokop @Poppi62 and Daniel St Johnston @StJohnstonLab @GurdonInstitute: https://t.co/tdyyVrYBJD
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Our new paper is out in @Development. https://t.co/HTA2XIvMAj
@StJohnstonlab @GurdonInstitute @Poppi62
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Do you want to convert an old microscope base to a light-sheet microscope that can image standard glass slide samples? Check out our new paper from @StJohnstonLab @GurdonInstitute in https://t.co/4O6TBRV9Sb
#OSA_BOEx
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Checkout our new preprint where we integrate OPM (single objective light sheet) into a standard microscope base. https://t.co/VRU26L3hkd
biorxiv.org
In this work we present an Oblique Plane Microscope designed to work seamlessly with a commercially available microscope base. To support all the functionality offered by the microscope base, where...
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Have a paper that has been reviewed elsewhere? Journal of Cell Science is pleased to consider such manuscripts for fast-tracked decision making. Send us your manuscript together with the full set of reviews and decision letters, and we’ll use these to make a decision. Find out
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Funded PhD studentship available in our newest lab - so new, it is not even open yet! (Group leader Sumru Bayin arrives in March.) Join Sumru in October to work on 'Age-dependent regenerative mechanism in the brain'. Closing date 07 Feb. https://t.co/xj7PUV2nyp
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How is one Oocyte specified from potential many? Read the latest work driven by Dima from our lab! https://t.co/rMBB40Jkga
science.org
Patronin and Dynein amplify weak asymmetry to specify which cell becomes an oocyte in a germline cyst in Drosophila.
JUST OUT in Science: Nashchekin et al. of the St Johnston lab reveal a molecular mechanism underlying the oocyte specification process, using Drosophila as a model. https://t.co/rSVh8QfTil
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We are looking for a new postdoc to study the composition and role of tricellular adherens junctions in epithelial morphogenesis. In collaboration with @StJohnstonLab and @LabBuckley. For more info see https://t.co/AAMvDC34A7. Please share & RT. @PDN_Cambridge (@Cambridge_Uni)
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All for one, and none for the rest: Symmetry breaking in oocyte determination @WilcocksonScott highlights new work by @StJohnstonLab
https://t.co/RS5Kp0iULa
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The silent conductor of cortical polarisation: asymmetric activation of Myosin-II orchestrates A/P axis establishment in Drosophila. Highlighting new work from @StJohnstonLab, including author comments. https://t.co/wtogH5LZMi
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"This discovery paves the way for new kinds of [cancer] prevention and intervention strategies that target the mechanisms that promote...cell competition." New study of how tumour cells colonise the intestinal epithelium out now from the Simons lab: https://t.co/QpvFd1I9Oa
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So great to see this published! Spearheaded by @ProfHao, @EdwardAllgeyer and Dong-Ryoung Lee, and made possible by our fantastic collaborators @ProfMartinJBoo1 @DopOxford @LynnCooley11 @BiedererLab @jacopoantonello @lenakumba @Fran_Bottanelli @phylicia_kidd @LessardMark
So pleased to announce this paper that came out yesterday! Pushing the limits of STED for tissue imaging!
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Checkout our new preprint where we develop a line scanning confocal system to do multi-colour super resolution imaging (DNA-PAINT) in Drosophila tissues. @EdwardAllgeyer @GurdonInstitute @Cambridge_Uni
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Happy to be part of this work. Ed & George, our microscope builders, developed the custom STED scope and helped with imaging for this project! @EdwardAllgeyer @GurdonInstitute
Beautiful microtubules are tuneable to regulate heart cell contractility after heart attack. Check out our Nature paper about the role of this promising therapeutic target MARK4 in heart failure! Many thanks to our funding bodies and our brilliant collaborators. @TheBHF
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📢I am thrilled to announce that I will join the @GurdonInstitute at the @Cambridge_Uni as a group leader in Spring 2022. The Bayin Lab will study the age-dependent regenerative mechanisms in the brain.
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Excited to share a preprint with some work from my undergrad project in the St Johnston lab! 🪰 we show an important role for the MT (-) end binding protein Patronin in Drosophila oocyte selection https://t.co/a4Vm05i0WT
biorxiv.org
In mammals and flies, only a limited number of cells in a multicellular female germline cyst become oocytes, but how the oocyte is selected is unknown. Here we show that the microtubule minus...
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Symmetry breaking in the female germline cyst https://t.co/r0SsKbydfJ
#bioRxiv
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Fundamentally important paper! Oocyte specification from the germline cyst cluster was always so mysterious to me! This work on the role if patronin in symmetry breaking is amazing! #oocyte #devbio
https://t.co/cnfSMD9IM5
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