SpanglerLab
@SpanglerLab
Followers
831
Following
45
Media
1
Statuses
93
The Spangler Lab at Johns Hopkins University integrates structural biology, molecular engineering, and translational immunology to design new disease therapies.
Baltimore, MD
Joined May 2018
Thrilled to share our new article in @acsnano .on the use of a hydrogel-based platform developed by the lab of @dinodicarlo for immune phenotyping at the single cell scale:
pubs.acs.org
The ability to characterize and separate cells based on their surface marker expression profiles using flow cytometry revolutionized our understanding of the immune system at the level of single...
1
1
7
Delighted to share our new article in @MolTherapy on novel bispecific VEGF antagonist proteins for treatment of eye diseases: .
0
0
6
Thrilled to share our new collaborative research on CAR NK cell engineering with @BonifantLab just published in JITC:.
jitc.bmj.com
Background Natural Killer (NK) cells have intrinsic anticancer activity that can be redirected toward acute myeloid leukemia (AML) with chimeric antigen receptor (CAR) engineering. Here, we study the...
0
2
10
Excited to share our lab's new review article in @trendscancer, surveying recent work in engineering growth factor systems to advance cancer therapy: .
0
1
20
0
3
0
So honored to have our cytokine/antibody fusion protein work featured on the cover of @JCI_insight! Huge thanks to Ann Seliger for the beautiful illustration.
1
0
11
Excited to share our latest work by Elissa Leonard, Jakub Tomala, and colleagues on the the design of cytokine/antibody fusion proteins for cancer immunotherapy published in @JCI_insight!.
0
1
12
RT @CellChemBiol: 👀Preview of Ludwig et al.: Sharks give a handle to potent anti-tumor multiparatopic antibodies inducing membrane depletio….
0
2
0
Congratulations to Seth, Pao, Ben, and team on their new multiparatopic downregulating antibody article in @CellChemBiol! Huge thanks to our fantastic collaborators as well! @hdooley13 @Imaging4Health .
2
6
13
Thrilled to share that Dr. Spangler has been promoted to Associate Professor with Tenure in the departments of Biomedical and Chemical & Biomolecular Engineering at Johns Hopkins. Deeply grateful for the trainees, mentors, colleagues, and collaborators who made this all possible!.
18
6
124
The Spangler Lab is deeply honored and grateful to receive a Stage 2 Damon Runyon-Rachleff Innovation Award from the Damon Runyon Cancer Research Foundation @DamonRunyon!
6
5
61
Congratulations to Justyn, Pao, and Ben on their fantastic antibody article out in Annual Review of Chemical and Biomolecular Engineering!.@AnnualReviews .
1
3
13
Congratulations to Jakub Tomala and Shanelle Cao on their new review article on anti-cytokine antibodies in Journal of Immunology @J_Immunol!.
academic.oup.com
Abstract. The delicate balance of immune homeostasis is regulated by the interactions between cytokines and their cognate cell surface signaling receptors.
0
0
20
RT @susannagreer: Check out my latest article: I’m stuck on how great this research is! via @LinkedIn.
linkedin.com
In this week’s article I’m glued to a study from the V Foundation grantee Dr. Jamie Spangler at The Johns Hopkins University.
0
1
0
RT @JGreenGroup: Jan '24 #Workshop #Advances in #Immunoengineering! FREE Registration . Exciting speakers include….
0
4
0
Congratulations to Luke Tomasovic (@luketomasovic11), Kathy Liu, Dr. Derek VanDyke, and Charina Fabilane on their new review article on IL-2 therapies for autoimmune diseases out in @BioDrugsJournal!.
link.springer.com
BioDrugs - The interleukin-2 (IL-2) cytokine plays a crucial role in regulating immune responses and maintaining immune homeostasis. Its immunosuppressive effects have been harnessed...
0
3
17
Delighted to share recent PhD laureate Dr. Aliyah Silver's new article on engineering a tumor-targeted cytokine/antibody fusion protein in @CellRepMed! Thanks to @JGreenGroup and @jishiharalab for working together with us on this story.
0
1
14
Congratulations to Derek and Paul on their new article in Journal of Biological Chemistry! .@jbiolchem.
0
2
12
Congratulations to Derek and Paul on their new article in Journal of Biological Chemistry! @jbiolchem .
1
0
7