Sheiner lab
@SheinerLab
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#parasite #toxoplasma #toxoplasmosis #mitochondria
Glasgow, Scotland
Joined May 2015
RT @MVLS_NERD: Hi NERDs! Another reminder for our Webinar event on 18 Sep, 12-1pm! Welcome to join us!.Scan the QR code for free registrati….
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Our session explored how studying bioenergetics enzymes via structural biology in divergent protist sheds light on the role of these enzymes and their assemblies across eukaryotes and on how the function in the context of each organisms’ specialised needs.
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A first #ICOP25 day 2 highlight: Dayana Salas-Leiva @RossWaller3 using LOPIT to ask not only what makes a symbiotic relationship, but what baggage is left after a break-up. Stay tuned!
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Some great models used to study endosymbiosis and what does it take to make a stable relationship:. Julius Lukes LOPIT of Insect Trypanosomes reveals new host-endosymbiont interactions. Ellen Yeh Epithemia diatoms probes the underlying mechanisms of establishing endosymbiosis
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First - a vivid discussion about determining the origin and early evolution of eukaryotes @andrewjroger @McfaddenGeoff (AKA obnoxious pink T-shirt man)
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RT @MESAmalaria: 🚨 #MPMXXXVI Update! The abstract submission deadline is June 27 — don’t miss your chance to share your research!. 📅 Check….
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RT @RitaTewari: We are looking for motivated and enthusiastic research fellow to join our group to investigate on #ERC project on cell divi….
jobs.nottingham.ac.uk
Applications are invited from highly motivated and enthusiastic candidate to the above role to investigate and perform research to disseminate findings on a ERC project “Unravelling the atypical...
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RT @MedsforMalaria: 📢 Calling all African scientists. Do you have an idea that can help accelerate #malaria drug discovery? MMV’s 8th Afric….
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RT @veupathdb: Make open access to tools and data part of your annual giving by making a tax deductible donation to VEuPathDB. This resourc….
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RT @ParasiteMatt: Looking for a fully-funded D. Phil. / Ph.D. studentship in structural biology and vaccinology? Come to join our team. Ful….
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RT @sabrina_absalon: 🎉 Join Us for Parasite Day with PiP 2025! We are thrilled to announce Parasite Day with @PiParasitology on June 27, 2….
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RT @KeithRMatthews: Please consider applying for this post doc position in our lab if you have excellent bioinformatics and wet lab skills,….
elxw.fa.em3.oraclecloud.com
This project will seek to understand the basis of increased virulence after long term coinfection by a combination of genomic, transcriptomic and laboratory manipulation of the selected parasite...
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Other complex III inhibitors are being developed as drug leads for apicomplexan diseases. Together with Stone Doggett and colleagues at @OHSUNewswe we showed how the drug-lead ELQ-300 binds Toxoplasma complex III and designed a more potent version.
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Atovaquone is a clinically used drug for apicomplexan diseases such as #malaria and #toxoplasmosis, but its precise mechanism of inhibition was unknown. We showed how atovaquone interacts with Toxoplasma complex III and why it is selective to apicomplexan compared to human.
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@AndrewEMaclean Respiratory complexes form “super-complexes” whose physiological function is debated, and assembly only studied in a few organisms. We showed that apicomplexan conserved proteins mediate III2-IV supercomplex formation, and that this provides competitive growth advantage.
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Read @AndrewEMaclean and Alex Mühleip phenomenal work on the Toxoplasma mitochondrial complexes III and IV here:. Key highlights in the thread below.
nature.com
Nature Structural & Molecular Biology - Here the authors demonstrate that the assembly of mitochondrial respiratory supercomplex (III2–IV) from Toxoplasma gondii is critical for parasite...
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