Simone Immler
@SimoneImmler
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Professor of Genetics and Reproduction @biouea Founder and Scientific Director of Virilitas Labs Ltd https://t.co/PjwMR9e6Hu
University of East Anglia, UK
Joined August 2014
We had a great end to 2024 publishing: The Zebrafish Sperm Proteome https://t.co/KUbz7Z7PsU We described >5400 sperm proteins generating a great atlas for future work! Spearheaded by PhD student @JaymeCohenBIO with great collaborators at @biouea and @JohnInnesCentre
analyticalsciencejournals.onlinelibrary.wiley.com
One of the key processes that forms the basis of fertilisation is the tight interaction between sperm and egg. Both sperm and egg proteomes are known to evolve and diverge rapidly even between...
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This is a simple parsimonious model to explain the evolution of lifespan extension by dietary restriction and other forms of stress that suppress fertility. Happy to be part of this exciting study!
1/8 Why does eating less extend lifespan? 🧬 We often think about saving energy or recycling waste - but we show how evolution acting on mutation load can generate longer life on low food 🧵 and preprint below: 🔗 https://t.co/xoP6WGq1Hb
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🚨Our new paper @SimoneImmler FishPi: a #bioinformatic prediction tool to link #piRNA and #transposable elements Read now in Mobile DNA >> https://t.co/0USpkO5VX2 ✅ Covers many species (more to come) ✅ GUI based software #TESky #zebrafish #transposons
@biouea 🐟🥧🥧🥧🥧🥟
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We had a great end to 2024 publishing: The Zebrafish Sperm Proteome https://t.co/KUbz7Z7PsU We described >5400 sperm proteins generating a great atlas for future work! Spearheaded by PhD student @JaymeCohenBIO with great collaborators at @biouea and @JohnInnesCentre
analyticalsciencejournals.onlinelibrary.wiley.com
One of the key processes that forms the basis of fertilisation is the tight interaction between sperm and egg. Both sperm and egg proteomes are known to evolve and diverge rapidly even between...
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🚨 Happy to share my latest preprint on #polarbear #transposon activity in response to diverging climates in #Greenland #TEsky 🐻❄🌞❄️🧬👩💻
Diverging transposon activity among polar bear sub-populations inhabiting different climate zones https://t.co/PKd8NwiBw8
#biorxiv_evobio
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🚨Pleased to share our latest preprint on #zebrafish #geneexpression and #transposons in #sperm & #embryos exposed to social stress
Environmentally induced variation in sperm sRNAs is linked to gene expression and transposable elements in zebrafish offspring https://t.co/MG1G7tVI1n
#biorxiv_evobio
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I finally caved and am now on bluesky - help me finding you and follow me there @immler.bsky.social and send me starter packs! Thank you!
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We have PhD position advertised in evolution of ageing with Tracey Chapman and @SimoneImmler: Please contact me if you have questions about the project or about this PhD programme https://t.co/6xF38jlQJH
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Why is there so much diversity in male seminal fluid proteins? Funded PhD position available with Tracey Chapman @biouea Research team includes @WolfnerLab , @WHaerty , @SimoneImmler and me https://t.co/vkO34A5kJn Applications deadline Nov 25
biodtp.norwichresearchpark.ac.uk
CHAPMAN_U25DTP2
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I am also incredibly proud of this preprint: Gum Arabic (Acacia senegal) enhances reproduction and modulates the microbiota-gut-brain axis.... https://t.co/fmUVsDEbLB Again a massive team effort by @Ko0L_J_ @asdfjohnny @AliceGodden @JaymeCohenBIO et al!
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Incredibly excited to share our preprint ( https://t.co/eNPIHa1S2Z) from @SimoneImmler’s Lab 🥳! By harnessing genomics, proteomics, and phenomics, we show that selecting high-quality sperm within an ejaculate could reduce the risk of diseases in future generations 🤯!
biorxiv.org
Males produce millions of sperm in a single ejaculate, but only a single sperm fertilises the egg. Fertilisation is the perfect opportunity for natural selection where sperm of poor quality are...
I am incredibly proud of this paper in preprint: Within-ejaculate haploid selection reduces disease biomarkers in human sperm https://t.co/bySTSaYBJD It has been long in the making and has been a true team effort! @danielmarcu @JaymeCohenBIO @AliceGodden @GAlavioon et al!
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I am incredibly proud of this paper in preprint: Within-ejaculate haploid selection reduces disease biomarkers in human sperm https://t.co/bySTSaYBJD It has been long in the making and has been a true team effort! @danielmarcu @JaymeCohenBIO @AliceGodden @GAlavioon et al!
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I am also incredibly proud of this preprint: Gum Arabic (Acacia senegal) enhances reproduction and modulates the microbiota-gut-brain axis.... https://t.co/fmUVsDEbLB Again a massive team effort by @Ko0L_J_ @asdfjohnny @AliceGodden @JaymeCohenBIO et al!
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Selection within the ejaculate of men results in genetic changes in key genes involved in neurodevelopment, cell signalling and cell proliferation and that the 'fitter' sperm in an ejaculate exhibit reduced expression of biomarkers for neurodevelopmental disorders and cancers
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I am incredibly proud of this paper in preprint: Within-ejaculate haploid selection reduces disease biomarkers in human sperm https://t.co/bySTSaYBJD It has been long in the making and has been a true team effort! @danielmarcu @JaymeCohenBIO @AliceGodden @GAlavioon et al!
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Germline removal benefits males more than females - led by @martin_i_lind in @AgingCell : https://t.co/XAZO5Moqpo (see earlier bioRxiv link below). Stress resistance improved in both sexes. Remarkable congruence with killifish work https://t.co/nBtI1OSHp9
@ItamarHarel
pubmed.ncbi.nlm.nih.gov
Classical evolutionary theories propose tradeoffs among reproduction, damage repair and lifespan. However, the specific role of the germline in shaping vertebrate aging remains largely unknown. In...
How does germline removal affect lifespan in females and males? There are theoretical arguments to suggest that germline is more costly to maintain in males, @martin_i_lind and friends tested this in C. remanei 1/2: https://t.co/ws4BzVDoao
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Reduced insulin/IGF-1 signalling upregulates two anti-viral immune pathways, decreases viral load and increases survival under viral infection in C. elegans by @E_Duxbury et al
📢New Open🔓 Access Paper Reduced insulin/IGF-1 signalling upregulates two anti-viral immune pathways, decreases viral load and increases survival under viral infection in C. elegans by Elizabeth M. L. Duxbury & @AlexeiMaklakov et al. https://t.co/RSIyIbKxRD
#insulinsignalling
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I am very happy to announce the recent publication of a beautiful theory paper with @mscott0106 and Karl Mackintosh (not on X) on the interactions between mating system evolution and haploid gametic selection in @PLOSGenetics
https://t.co/ExN0jWouRV
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Merger of NYRA @YoungAndrology with @EAAndrology is highlighted in this society news article published in Andrology 🤩 https://t.co/MpHUluwIrx
@AndrologyASA
We are happy to share the story about NYRA/ @EAAndrology Merger: https://t.co/9kuc8S5WVv The Andro family is growing 🫱🏼🫲🏾✨
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I am very happy to announce the recent publication of a beautiful theory paper with @mscott0106 and Karl Mackintosh (not on X) on the interactions between mating system evolution and haploid gametic selection in @PLOSGenetics
https://t.co/ExN0jWouRV
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