Neta Shlezinger
@ShlezingerLab
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Assistant Professor of all things fungi, from their nifty viruses to their inevitable demise 🍄 @NSfungiLab @HUJIAgri
Israel
Joined March 2019
🚨 Fungi + viruses + mammalian lungs? Buckle up! Our new paper in.@natmicrobiol.nature.com.uncovers the story of a deadly fungus and its gnarly viral hitchhiker — and how this duo may change how we diagnose & treat fungal disease 🍄🫁🚨 ⬇️.
nature.com
Nature Microbiology - A mycovirus infecting the pathogenic fungus Aspergillus fumigatus enhances its stress tolerance and virulence in mice.
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Our study on a mycovirus that boosts fungal virulence is now out — and beautifully covered in this Behind the Paper piece by Amariliz Rivera . Huge thanks for capturing the heart of the story so thoughtfully.
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RT @RNA_Life: 🤯 One of the coolest stories I've ever come across showcasing virus-host-superhost interactions. This is a major paradigm in….
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RT @Symbionticism: A vital virus (again) provides a benefit to fungi under oxidative stress, heat stress, and within the murine lung. Fun!.
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@LererVanda @MarinaRocha0912 @jon_adeoye @AmeliaBarberPhD 💰 And of course, thanks to.@ERC_Research, @nouvelles_CIFAR .and.@stem_program.— without your support, this story would still be stuck in our grant drafts.
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@LererVanda @MarinaRocha0912 @jon_adeoye ✨ Laura Fabre & @AmeliaBarberPhD — for brilliant support, sharp insights, and being the kind of collaborators everyone wishes they had.Couldn’t have done it without you — and honestly, wouldn’t have wanted to 🎯⬇️.
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🎉 Mega thanks to:.✨ @LererVanda for boldly launching this exciting line of research.✨@MarinaRocha0912 for steering this project and bringing it triumphantly across the finish line.✨@jon_adeoye & all Shlezinger lab members for your unwavering support and teamwork ⬇️.
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So maybe the next time someone has a fungal infection, the question shouldn’t just be “Which fungus?” but also “Which virus is it carrying?" . And speaking of things riding along — time to thank the amazing people who made this journey possible 👇.
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Why does this matter?.🧪 Mycoviruses are barely on the radar in human disease. Our work shows they:.✔️ Shape fungal virulence.✔️ Influence host–pathogen interactions.✔️ Could be diagnostic markers.✔️ May be therapeutic targets ⬇️.
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💡 Therapeutic twist:.We treated infected mice with antivirals during fungal infection. Result?.📉 Lower mycovirus load.📈 Higher mouse survival.Suggesting that targeting the virus could be a new way to fight fungal disease. ⬇️.
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When we “cured” the fungus of its virus, it:.⬇️ Made fewer spores.⬇️ Produced less melanin.⬇️ was less stress resistant.⬇️ Was less virulent in mice.Turns out, the virus helps the fungus fit the harsh environment of the host. ⬇️.
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it’s wired into the regulation of key fungal processes, boosting heat resistance, dodging oxidative bursts, and helping the fungus thrive in mouse lungs. ⬇️.
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Our culprit: AfuPmV-1M, a dsRNA virus that’s set up permanent residence inside A. fumigatus. Turns out this isn’t just a harmless hitchhiker ⬇️.
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Meet Aspergillus fumigatus — responsible for ~65% of all invasive fungal infections in humans, with mortality rates up to 50%. We asked: could a mycovirus (a virus that infects fungi) be quietly steering fungal disease in humans?⬇️.
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RT @lab_oren: My lab was totally destroyed tonight by an Iranian missile. Nobody was hurt. Flies, plasmids, cells, equipment - all gone. He….
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Had an amazing day of nifty mycology with all my Israeli funguys 🍄! Big thanks to @covolab for organizing and to all the fantastic speakers, including our very own @jon_adeoye. Looking forward to more fungal adventures!
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RT @JorgeAmich: 💥We have a postdoctoral position to work on an exciting European collaborative project💥. More details below. Those interest….
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🚨Postdoc opportunity alert! .Exciting postdoc position available in a top-tier lab focused on the genetics of human fungal pathogens. Don’t miss this chance to be part of groundbreaking science! 🍄.
My group is recruiting a postdoc to study how environmental interactions shape the virulence of human fungal pathogens. Please RT! . #postdocjobs #academicjobs #microbiologyjobs
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🚨New manuscript alert! Interested in natural antimicrobial peptides? Check out this new manuscript led by @AsafLevyHUJI’s group and our very own @MarinaRocha0912 in @NatureMicrobiol! It was a great privilege contributing to this nifty collaborative project.
I am happy to share my article as a first author in @NatureMicrobiol with @ShlezingerLab and @AsafLevyHUJI. Thank you for the opportunity and trust in my work!.If you want to know a little more about antimicrobial toxins, especially with antifungal action, I recommend the read!.
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RT @lab_oren: A year in ongoing trauma is difficult to explain, but it’s difficult for me to concentrate on anything else. Sorry for the lo….
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