Shan-Lu Liu
@ShanLuLiu1
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RT @biorxiv_micrbio: IFN-inducible Human Phospholipid Scramblase 1 (PLSCR1) ProteinRestricts HIV-1 Infection by Inhibiting Membrane Fusion….
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XEC exhibits increased infectivity, enhanced nAb evasion, distinct antigenicity, reduced cell-cell fusion, and decreased S1 shedding, changes attributed to F59S and T22N mutations. Removal of glycosylation sites in XEC and KP.3.1.1 restored nAb titers, fusion and S1 shedding.
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We are pleased to share our new work led by postdoc @pei_li30290: Immune Evasion, Cell-Cell Fusion, and Spike Stability of the SARS-CoV-2 XEC Variant: Role of Glycosylation Mutations at the N-terminal Domain
biorxiv.org
SARS-CoV-2 continues to evolve, producing new variants that drive global COVID-19 surges. XEC, a recombinant of KS.1.1 and KP.3.3, contains T22N and F59S mutations in the spike protein’s N-terminal...
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RT @CellCellPress: Now online! Viroid-like colonists of human microbiomes
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RT @HHMINEWS: We recently spent a day in the lab with 2024 @NobelPrize winner and HHMI Investigator David Baker, where he discussed his gro….
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RT @AmerSocVirol: Hey ASV members! Do you know an outstanding early career virologist who deserves recognition? Consider nominating them fo….
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RT @JVirology: It's #PeerReviewWeek2024. @jvirology would like to thank and honor its many reviewers, especially these individuals who have….
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We observed decreased cell-cell fusion conferred by DelS31. Structurally, it strengthens the.interaction between NTD and RBD, leading the RBD to energetically favor the down conformation, thus becoming less accessible to ACE2 and some class 1 and class 4 antibodies.
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We found that a single NTD deletion DelS31 mutation resulted in over 9-fold decrease in nAb titer, distinct antigenicity, decreased S1 shedding, as well as increased resistance to elevated temperatures.
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Led by @pei_li30290, we found dramatic nAb evasion conferred by a single DelS31 mutation in the NTD of spike and increased conformational stability. DelS31 variants currently account for >70% of US COVID cases, should DelS31 be included in vaccine design?
biorxiv.org
During the summer of 2024, COVID-19 cases surged globally, driven by variants derived from JN.1 subvariants of SARS-CoV-2 that feature new mutations, particularly in the N-terminal domain (NTD) of...
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RT @mosconaporotto: Superb talks today at Symposium III #ASV2024 by Inger Damon, Raul Andino, Diego Diel, Erica Saphire, and Robert Langer.….
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ASV 2024: Spreading the word about virology research in an age of misinformation #ASV2024 @AmerSocVirol @OhioState @IDIatOSU @JVirology.
news.osu.edu
The American Society for Virology’s 43rd annual meeting hosted by The Ohio State University this week features some firsts for the organization: It is the largest meeting ever, attracting over 2,000...
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Similar does not mean the same …Thanks to >2,000 colleagues and friends for coming to ASV 2024 and it’s our honor to host you. #ASV2024 @AmerSocVirol @OhioState @IDIatOSU @JVirology
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RT @SSCLabQuips: Updates from the Journal of Virology Editors in Chief | Journal of Virology
journals.asm.org
When we stepped into the co-Editors in Chief role of the Journal of Virology (JVI) in 2022, one of our major goals was to make JVI a global journal that embraced all aspects of virology while...
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Convention center is connected to Hilton and walking distance to Hampton and Drury hotels, see map below. @AmerSocVirol #ASV2024
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ASV is teaming up with The Ohio State University and local Columbus transportation providers to offer free dedicated ASV shuttle services between the airport, university, and convention center. Please see the ASV 2024 Mobile App Whova for the most up-to-date information.
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