Shakir Ali Siddiqui
@ShakirAliSiddi4
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Postdoctoral Associate at University of Bristol in A J Mulholland Lab #compchem, Electric Field Catalysis, Enzyme Design, MD, QM/MM
Bristol, England
Joined October 2016
Read our new preprint where we have discussed how electric fields and solvent channels can shape the proton transfer pathways in Heme peroxidases. ChemRxiv:
🚨 Check out the updated version of our latest preprint with @AdrianMulholla1, @ShakirAliSiddi4, @marcvanderkamp, and many others!.📄 Read it here 👉
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RT @reynier_s: 🚨 Check out the updated version of our latest preprint with @AdrianMulholla1, @ShakirAliSiddi4, @marcvanderkamp, and many ot….
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RT @rashtrapatibhvn: Deeply saddened by the passing of Dr. MR Srinivasan whose contribution to India’s nuclear energy development program h….
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RT @kshatresh: A collaborative work with Dr. Ajoy Kapat is now online in @ChemEurJ . Congratulations Asrar @ShakirAliSiddi4 and all team. ….
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Had a great time presenting my work on electric field applications in de novo proteins, at 6th Manchester Multiscale Conference!.Grateful for the opportunity and discussions. Big thanks to my postdoc advisor, Prof. @AdrianMulholla1, for the support and guidance!. #ElectricFields
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RT @kshatresh: Our collaborative work with Dr. Ajoy Kapat group is published now in JOC, .Congratulations team, Asrar, Shakir @ShakirAliSid….
pubs.acs.org
Cleavage of the C–C triple bond is a unique pathway for the generation of new synthons. Nevertheless, the high bond dissociation energy, coupled with the acidic nature of the alkyne proton, renders...
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RT @sukumarfineart: Kshatresh Dutta Dubey (SNU) at Sagamore XX: Electric Field-Induced Catalysis in Enzymes. Can we design an enzyme (here….
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RT @kshatresh: I was thinking of myself among the smartest Molecular modelers. But I am proud of my PhD @ShakirAliSiddi4 , he is far superi….
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Thrilled to announce my latest paper in @ACSCatalysis! 🎉.It explores enzyme-based plastic degradation via Designed Local Electric Fields. Thanks to @kshatresh Sir. Check it out:.#biodegradation #enzymedesign.
pubs.acs.org
In enzymes, protein residues themselves carry charges and produce a preorganized local electric field (LEF). Such LEFs can be modified by strategically mutating the charged and polar residues to...
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RT @kshatresh: Here for the first time, we propose Cytochrome P450 scaffold for the plastic degradation using Insilico enzyme engineering b….
pubs.acs.org
In enzymes, protein residues themselves carry charges and produce a preorganized local electric field (LEF). Such LEFs can be modified by strategically mutating the charged and polar residues to...
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RT @kshatresh: Happy to share that our work where we explain the reaction mechanism of Carbapenem biosynthesis in Vitamin B12 dependent Rad….
pubs.acs.org
Due to the recent surge in antibiotic resistance, developing novel antibiotics is the demand of the time, and thus, a precise understanding of the catalytic mechanisms of enzymes involved in antibi...
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RT @kshatresh: Enzymes possess local electric field (LEF) which r pre-organized to optimize native rxn. Can such LEF be tweaked by strategi….
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Wrapping up an incredible journey with a memorable celebration. Grateful to my mentor @kshatresh for believing in my skills and helping me grow. Thankful to my fantastic labmates for the wonderful farewell and thoughtful gift. Your efforts made this day truly special.
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Thank you, Dr @kshatresh sir, for your unwavering support and guidance. I am honored by the examiner's praise and grateful to Prof. S.P. Rath, Prof. Ayan Datta, and @CForoutanNejad for their evaluation. Thanks to @ShivNadarUniv. Proud to be your 4th PhD graduate!.
Congrats Dr. @ShakirAliSiddi4 for defending thesis. I felt proud when examiner said " I m amazed by presentation of the candidate". Thanx Prof. S.P. Rath, Prof. Ayan Datta and @CForoutanNejad for evaluating thesis. BTW my 4th PhD graduated! Thanks @ShivNadarUniv @SanjeevSaGa
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The summary of my PhD thesis that made me Dr. Shakir Ali Siddiqui. ☺️☺️
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✨Big news: I have defended my PhD Thesis!✨. The journey has been intense, with many late nights, breakthroughs, and moments of doubt. But today, I'm proud and thrilled to say that it's all paid off. A huge thanks to my Research Advisor, Dr. Kshatresh Dutta Dubey.
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Accuracy 100%.
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RT @AU_priscila: Registration is open! Do not miss this opportunity to learn state-of-the-art techniques in #moleculardynamics and molecula….
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Delighted to share our perspective on Designed Local Electric Fields (D-LEFs) is getting highlighted by JACS Au. @snuchemistry.@kshatresh @thijsstuyver.
In this Perspective, the authors discuss how local electric fields (LEFs) can be exploited to improve the catalytic performance of supramolecular catalysts, such as enzymes. Learn more 📝 @kshatresh @thijsstuyver @ShakirAliSiddi4
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