Shabat Group
@ShabatGroup
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The home of Self-Immolative Dendrimers and Polymers
Tel Aviv University
Joined March 2017
The final version of this manuscript was published today in @angew_chem:
onlinelibrary.wiley.com
Novel phenylamine-substituted 1,2-dioxetanes were developed as efficient luminophores with enhanced performance in aqueous media requiring no additives compared to phenoxy-1,2-dioxetanes. The...
Just introduced: Phenylamine-1,2-Dioxetanes - a powerful revived class of chemiluminescent luminophores with high quantum yield and exceptional performance in aqueous bioassays. No enhancers needed. Today in @ChemRxiv ( https://t.co/wee1DFvlVw)
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Just introduced: Phenylamine-1,2-Dioxetanes - a powerful revived class of chemiluminescent luminophores with high quantum yield and exceptional performance in aqueous bioassays. No enhancers needed. Today in @ChemRxiv ( https://t.co/wee1DFvlVw)
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The final version of this manuscript was published in JACS Au:
pubs.acs.org
Chemiluminescence imaging has emerged as a powerful alternative to fluorescence-based methods, offering significant advantages such as reduced background noise, elimination of autofluorescence, and...
“Structure-Activity Optimization of Phenoxy-1,2-Dioxetane Precursors as Probes for Singlet Oxygen Yields Unprecedented Detection Sensitivity”, Appearing now in @ChemRxiv: https://t.co/Ig4v84HF0y
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Our latest paper is now out in @J_A_C_S ! We unveil a new strategy to access elusive free oxoboranes—highly reactive species—via bridged boranoanthracenes and aromatization-driven extrusion. Congratulations to the team! https://t.co/9QolAtxnaE
pubs.acs.org
We introduce a novel class of boranobornadiene derivatives, termed boranoanthracene, along with an in-depth study of their structures and reactivities. Using these versatile precursors, we propose a...
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The First Caspase-3 Chemiluminescent Probe. Appearing today in Bioconjugate Chemistry: https://t.co/gkpmyyRzqQ
pubs.acs.org
Caspase-3 is a pivotal enzyme in the apoptosis pathway that is responsible for executing programmed cell death through the cleavage of key cellular proteins. Existing fluorescence-based probes for...
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Appearing today in @Nature :
nature.com
Nature - Readily accessible enantioenriched sulfonylhydrazides and low loadings of an inexpensive achiral Ni catalyst can be used to control the stereochemical outcome of radical cross-coupling.
🚨RADICAL RETHINK: STEREORETENTIVE CROSS COUPLING UNLOCKED🚨 Today in @ChemRxiv ( https://t.co/UixXSDpA2R) the first method for stereoretentive radical cross-coupling is disclosed. No fancy ligands or redox needed—just a Ni-diazene twist. 120 years after Gomberg, a new chapter
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🚨RADICAL RETHINK: STEREORETENTIVE CROSS COUPLING UNLOCKED🚨 Today in @ChemRxiv ( https://t.co/UixXSDpA2R) the first method for stereoretentive radical cross-coupling is disclosed. No fancy ligands or redox needed—just a Ni-diazene twist. 120 years after Gomberg, a new chapter
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Big thanks to Derek Lowe for the thoughtful commentary on our manuscript! Your insights on antifungal research and the challenges we face in drug discovery are invaluable. What the Antifungals Are Really Doing | Science | AAAS
science.org
What the Antifungals Are Really Doing
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The final version of this manuscript was published in @BioconjChem: https://t.co/hXLK8d4Vma. Many thanks to @BaranLabReads and @RSFLab for this fruitful collaboration.
pubs.acs.org
ENPP-1 is a transmembrane enzyme involved in nucleotide metabolism, and its overexpression is associated with various cancers, making it a potential therapeutic target and biomarker for early tumor...
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“Structure-Activity Optimization of Phenoxy-1,2-Dioxetane Precursors as Probes for Singlet Oxygen Yields Unprecedented Detection Sensitivity”, Appearing now in @ChemRxiv: https://t.co/Ig4v84HF0y
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Finally, RADICAL CROSS COUPLING without the exogenous REDOX. We disclose in @ChemRxiv ( https://t.co/C4auh5reyl) a broadly general platform for achieving transformations that normally required excess metallic or chemical reducing agents or photochemical setups (and their
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The final version of this work was published today in @angew_chem: https://t.co/blEhGcykGC Many thanks to @JbaraM90 for the team effort.
onlinelibrary.wiley.com
The first PeT-based turn-on probe utilizing a chemiluminescent mechanism is presented. The probe is activated through a reaction between a quenched dioxetane-azide and a strained cycloalkyne,...
The FIRST chemiluminescent probe with a Turn-ON mechanism, utilizing a PeT mode-of-action. Insightful collaboration with @JbaraM90: Appearing today in @ChemRxiv: https://t.co/AyoMmQvTn9
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“Thymidine Phosphodiester Chemiluminescent Probe for Sensitive and Selective Detection of Ectonucleotide Pyrophosphatase 1”. Inspiring collaboration with @BaranLabReads, Appearing today in @ChemRxiv: https://t.co/g2sPwcbeJj
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Chemiexcitation Acceleration of 1,2-Dioxetanes by Spiro-Fused Six-Member Rings with Electron-Withdrawing Motifs (Doron Shabat and co-workers) @ShabatGroup #openaccess #AngewandteVIP
onlinelibrary.wiley.com
New phenoxy-1,2-dioxetanes bearing a spiro-fused six-member ring with different electron-withdrawing motifs were shown to have an accelerated chemiexcitation and increased stability compared to...
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The FIRST chemiluminescent probe with a Turn-ON mechanism, utilizing a PeT mode-of-action. Insightful collaboration with @JbaraM90: Appearing today in @ChemRxiv: https://t.co/AyoMmQvTn9
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The final version of this work was published in @JACS_Au:
pubs.acs.org
The chemiluminescent light-emission pathway of phenoxy-1,2-dioxetane luminophores is increasingly attracting the scientific community’s attention. Dioxetane probes that undergo rapid, flash-type...
In memory of Prof. Philip E. Eaton, a pioneer in the study of the Cubane molecular system: Boosting Chemiexcitation of Phenoxy-1,2-Dioxetanes through 7-Norbornyl and Homocubanyl Spirofusion Appearing now in @ChemRxiv: https://t.co/UUXKfPkzpo
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"Biocompatible Flash Chemiluminescent Assay Enabled by Sterically Hindered Spiro-Strained-Oxetanyl-1,2-Dioxetane" Productive collaboration with @RSFLab, @mifridm and @BiosynthGroup Appearing today in @ChemRxiv: https://t.co/Lxd0PTio5I
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The final version of this Preprint has been published today in @angew_chem:
onlinelibrary.wiley.com
New phenoxy-1,2-dioxetanes bearing a spiro-fused six-member ring with different electron-withdrawing motifs were shown to have an accelerated chemiexcitation and increased stability compared to...
A spiro-fused 6-member ring with inductive electron-withdrawing units yields stable phenoxy 1,2-dioxetanes with super-accelerated chemiexcitation: Continuing collaboration with @houk1000. Appearing today in @ChemRxiv: https://t.co/A4PQvQgox9
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Today we report in @J_A_C_S a novel and highly modular platform for mechanically triggered chemiluminescence (bright light emission) from polymers. Congrats to @PengLiuChem, Yu-Ling (Debbie), and coworkers! Collab with @ShabatGroup. @CaltechCCE @Caltech
https://t.co/KaLR8x93gr
pubs.acs.org
Mechanoluminescence, or the generation of light from materials under external force, is a powerful tool for biology and materials science. However, direct mechanoluminescence from polymers remains...
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