SextonLab
@SextonLabUM
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Discovering deeper links between drugs and diseases through high content analysis and machine learning. Located in Michigan Medicine.
Ann Arbor, MI
Joined March 2019
Congrats to our own @jesse_wotring in his most recent publication: validating lactoferrin’s anti-SARS-CoV-2 activity! https://t.co/1zLYFE2n4W
journalofdairyscience.org
Bovine lactoferrin (bLF), a naturally occurring glycoprotein found in milk, has bioactive characteristics against many microbes, viruses, and other pathogens. Bovine lactoferrin strongly inhibits...
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Drug-induced liver injury has always been a burden on drug development, calling for better in vitro liver models. In this study, we combined a protocol for developing human liver organoids from iPSCs and a microfluidic “chip” system towards that goal.
A Multi-Omics Human Liver Organoid Screening Platform for DILI Risk Prediction https://t.co/nHiGtomiXH
#bioRxiv
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US Study Shows 'Several Drug Contenders' Kill SARS-CoV2 Infection in Cells
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We are happy to announce our SARS-CoV-2 drug repurposing screen has just been published in PNAS! This was a massive team effort that would not be possible without many, including @ChristianeWobus @TheSpenceLab @ArulChinnaiyan @momeara
https://t.co/fPRUm3p0lx
pnas.org
The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the associated disease COVID-19, requires therapeutic in...
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Exciting to share our work from a strong collaboration! Such great work by @DayFerrerTorres that we are thankful to be a part of.
It’s a super fun and exciting day in the @TheSpenceLab! An entirely new research direction for the lab studying the adult human esophagus led by @DayFerrerTorres. Collaboration with many colleagues including @SextonLabUM @Charles_J_Zhang
https://t.co/0BQzEJ6kza
@MichaelDame1
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Congrats to our three grad students, @Charles_J_Zhang, @MedChemMcCarty, and @jesse_wotring for flawlessly advancing into candidacy! Big things to come!
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As #COVID19 manifests differently in different tissues we study their effects on a wide variety of cell lines. Cardiomyocytes are particularly interesting because you can watch them beat! Great work from Carla, @psychsiren!
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Needed a physiological lung model, so I made one in an “organ-on-chip” system grown with @tristanfrum’s airway basal cells. Air flow and stretch applied to mimic breathing results in mucosal and ciliated cells. Hope to validate this for #COVID19 and other diseases! @SextonLabUM
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@jesse_wotring @SextonLabUM Thank you for doing this important research, and we're thrilled to be a part of it!
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@CaymanChemical Always making research possible! We used your FDA approved compound library to find drugs that can help fight SARS-CoV-2! Thank you for your help from a former Cayman Chemical intern under Holly Pierzynski and Nathan Layle! @SextonLabUM
biorxiv.org
The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the associated disease COVID-19, requires therapeutic interventions that can be rapidly translated to...
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We identify 15 FDA approved drugs and lactoferrin with possibility of treating SARS-CoV-2.
Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19 https://t.co/FcPQamB5tD
#bioRxiv
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Our Covid19 drug repurposing screen found 15 FDA-approved drugs and the dietary supplement Lactoferrin have strong antiviral effects in vitro: https://t.co/AcyTd405al
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Tune in to this recent Michigan Minds podcast, where Jonathan Sexton describes our ongoing project in addressing COVID-19. https://t.co/3Riae7VCSD
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ShoutOut to UM Center for Drug Repurposing in Scientific American's new article on drug repurposing:
scientificamerican.com
Dozens of compounds approved for other purposes can kill cancer cells selectively
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Check out our collaborative study with Dr. Rishel Vohnoutka where we used @CellProfiler to quantitate cytoskeletal structure using radial distribution of intensities! On cover of MBoC -
molbiolcell.org
Focal adhesion (FA)-stimulated reorganization of the F-actin cytoskeleton regulates cellular size, shape, and mechanical properties. However, FA cross-talk with the intermediate filament cytoskeleton...
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@jonnysexton introducing the new MICHR Drug Repurposing center, designed to find new usage in old drugs! https://t.co/Np6AVBjaD0
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Hello world! Tomorrow marks the beginning of U of M Drug Repurposing. Please join us at our Town Hall where we will be introducing our services. Details:
drugrepurposingtownhall.splashthat.com
Are you a U-M chemist, clinician-scientist, or faculty/staff involved in drug development research? Interested in the latest information on drug repurposing research? The Michigan Institute for...
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Dr's. Cunningham and Sexton fireside chat discussing innovation at the University of Michigan.
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Take a quick look at #SextonLab’s updated personnel page! https://t.co/xRJQc0E8QL
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