Sergio Niñerola
@SergioNi92
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Bioinformatics and epigenetics in neuronal plasticity
Instituto de Neurociencias(IN)
Joined October 2021
🔥 A new study led by @KardamakisAndre lab at @NeuroAlc reveals that the brain’s ability to detect what matters in a visual scene is over 500 million years old. 🗞️@PLOSBiology More info 👇 https://t.co/aM69aDFjIG
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You can read the full paper here 👇 https://t.co/3roqTIcxAi
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Incredibly happy to share the recent study in which I contributed where we characterized cell-specific epigenetic erosion of developmental genes in HD mouse striatum. Congrats to Baptiste Brulé, Karine Merienne and all the team for this amazing work! 🖥️🔻 https://t.co/NaX7fTjmA6
nature.com
Nature Communications - Loss of epigenetic information is a hallmark of cellular aging. Here, authors examine changes in the epigenetic landscape at three stages of Huntington neurodegenerative...
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Our latest work is out!!! 🥳 @LabEHerrera @NeuroAlc @Augusto_ER, @CSICVal, @UniversidadMH, @CaixaResearch, @AgEInves, @CienciaGob, @SEBiolDev, published in #JNeurosci @SfNJournals, https://t.co/aHxAAKbIxJ
https://t.co/e4skzrqd4x Short thread below 🧵
jneurosci.org
Eph/ephrin signaling is crucial for organizing retinotopic maps in vertebrates. Unlike other EphAs, which are expressed in the embryonic ventral retina, EphA4 is found in the retinal ganglion cell...
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#JNeurosci | @FedericoMiozzo et al. used mice to investigate how a gene associated with autism spectrum disorder and depression, Protocadherin 9, plays a role synaptic dysfunction and brain pathology. This study provides important molecular and synaptic insight. @NeuroAlc
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Want to know (more) about activity-induced gene transcription (also called, excitation-transcription coupling)? Here ya go: https://t.co/cIwdJIqTiD Shout out to my co-editor @Serenadudette and all contributing authors for a fantastic job!
link.springer.com
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Many thanks to editors @RamenNSaha and @Serenadudette for their incredible work! Hope you enjoy it! New Genome-Wide Technologies to Study Activity-Regulated Transcription https://t.co/b85s6R4FdU
link.springer.com
Activity-driven transcription is a critical step in the response of neurons to stimuli. It is initiated by an increase in intracellular Ca2+ at activated synapses that triggers a cascade of phospho...
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The 2nd edition of "Transcriptional Regulation by Neuronal Activity: To the Nucleus and Back" is out! @BarcoLab and I contributed the final chapter on how neuronal activity drives transcription and chromatin changes, and how genome technologies help study them.
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1/2 Sixteen years after the first edition, we're honored to contribute again to the essential volume edited by Ramendra N. Saha and @Serenadudette. The book explores how neurons respond to activation throughout the lifespan, from neurodevelopment to learning. #BarcoLab
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2/2 Our chapter focuses on the impact of new genome-wide technologies and their application in studying activity-driven transcription. Don’t miss it! https://t.co/k1qKF2R5eR
@NeuroAlc @SergioNi92 #BarcoLab #Neuroscience
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Check out our preview in Neuron about the amazing work done by @EricJNestler lab interrogating the epigenetic basis of stress resilience to adult social defeat stress and early life stress! @barcolab @NeuroAlc You can access to it in the following link: https://t.co/4KqxNYEcD3
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Take a look at our latest book chapter on Engrams! Angel Barco and @miguelfr92 have collaborated with other renowned researchers to compile the latest advances on engrams. Their chapter focuses on the underlying transcriptional and epigenetic mechanisms. https://t.co/BoW4nNAdO6
link.springer.com
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🔥 New review article by @BarcoLab is now published on @TrendsMolecMed 🔝 This work examines the role of epigenetic alterations, resulting from genetic and environmental influences, as a central factor in ASD, delving into its contribution to pathogenesis & treatment strategies.
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📣We're excited to share our latest review article on the role of epigenetics in the etiology of ASD! Check it out here: https://t.co/VSEK15tVBm Don't miss it! 📸 @TrendsMolecMed
🔥 New review article by @BarcoLab is now published on @TrendsMolecMed 🔝 This work examines the role of epigenetic alterations, resulting from genetic and environmental influences, as a central factor in ASD, delving into its contribution to pathogenesis & treatment strategies.
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Another day at FENS! Our colleague Miguel Fuentes presented his poster on mapping engram cells of the whole brain! While Sergio Niñerola presented his results on the transcriptional regulation that takes place upon neuronal activation. Such an exciting experience! #FENS2024
✨ #FENS2024: Day 3 Wrap-Up! Today, we delved deep into the complexities of the #brain with a dynamic lineup of lectures, events, and activities. What are you most looking forward to tomorrow? 💫 Explore tomorrow's programme here: https://t.co/UUsA9L6LGE
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If you're interested in epigenetics, identity and activity programs in neurons, come see my poster n° 348 this afternoon at #FENSForum2024 @BarcoLab See you there!!!
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People! ✨ Super proud to participate and see this interesting research published. Cux2 alters brain folding patterns, inducing folds in smooth mouse brains and changing fold patterns in ferrets. @NeuroAlc @UniversidadMH
@CSIC
https://t.co/oFmNgxdg9l
science.org
Epigenetic regulation of Cux2 expression triggers downstream signaling to implement the protomap of cortex folding pattern.
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Gene regulatory landscape of cerebral cortex folding | Science Advances
science.org
Epigenetic regulation of Cux2 expression triggers downstream signaling to implement the protomap of cortex folding pattern.
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It was already one month ago that Marta outstandingly defended her thesis! Congratulations again Dr Alaiz!! For the past years, Marta has been working on the role of epigenetic regulation in gene-environment interactions. Good luck in this new chapter! We’ll miss you!
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