Sean Pitroda, M.D.
@SeanPitroda
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Radiation oncologist & cancer biologist @UChicago @LudwigCancer investigating oligometastatic disease & interplay between radiotherapy & immunotherapy
Chicago, IL
Joined September 2020
🧵1/.Tumor aneuploidy—long viewed as a hallmark of cancer—is emerging as a key biomarker of immune resistance. In our latest @NatureGenet Perspective, we explore how aneuploidy can guide immunotherapy decisions and shape future treatment strategies. 🔗
nature.com
Nature Genetics - Aneuploidy, a defining feature of cancer, is linked to immune evasion and therapeutic resistance. This Perspective reviews approaches to quantify tumor aneuploidy and evaluates...
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RT @UChicagoRadonc: UChicago is recruiting for a faculty radiation oncologist position. We'll be meeting candidates at ASTRO 2025. Check ou….
careers.astro.org
View jobs available on American Society for Radiation Oncology. Search for and apply to open jobs from American Society for Radiation Oncology.
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RT @UCCancerCenter: New study from @rweichselbaum and team show high-dose radiation triggers amphiregulin, a protein that weakens immunity….
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RT @nataliagandur: 💫🌟🔬 Facts and Hopes in Radioimmunotherapy of Oligometastatic Disease🌟💫.by @DrHuangDQ @SeanPitroda @rweichselbaum.📌 @CCR_….
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Congrats @rweichselbaum and UChicago collaborators on an amazing paper in Science Advances!. @UCCancerCenter @UChicagoMed.
science.org
A CAR T platform using engineered protein G variants and Fab scaffolds enables safe, adaptable, multi-targeted cancer therapy.
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RT @UCCancerCenter: Check out the excellent perspective published by Sean Pitroda, MD, and colleagues in @NatureGenet, highlighting how hig….
uchicagomedicine.org
A new study shows how combining immunotherapy with radiation may help overcome the issue of therapy resistance, offering a new framework for predicting treatment response and personalizing cancer...
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📢 New in Cancer Cell: Radiotherapy is essential for local control—but can it unintentionally accelerate growth of distant metastases? We examine how RT-induced EGFR signaling and immune modulation may fuel metastatic progression. 🧠🧬🔬.Read:
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RT @SeanPitroda: 10/.Read the full Perspective by Daniel Huang, @liamspurr, @rweichselbaum, and @SeanPitroda .👉 Let….
nature.com
Nature Genetics - Aneuploidy, a defining feature of cancer, is linked to immune evasion and therapeutic resistance. This Perspective reviews approaches to quantify tumor aneuploidy and evaluates...
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RT @SeanPitroda: 11/.Special thanks to @UCCancerCenter @UChicagoMed @UChicago @UChicagoRadonc @Ludwig_Cancer @LUNGevity.
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RT @SeanPitroda: 12/.Also, thanks to @UChicagoMed for highlighting our work!.
uchicagomedicine.org
A new study shows how combining immunotherapy with radiation may help overcome the issue of therapy resistance, offering a new framework for predicting treatment response and personalizing cancer...
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RT @SeanPitroda: 🧵1/.Tumor aneuploidy—long viewed as a hallmark of cancer—is emerging as a key biomarker of immune resistance. In our lates….
nature.com
Nature Genetics - Aneuploidy, a defining feature of cancer, is linked to immune evasion and therapeutic resistance. This Perspective reviews approaches to quantify tumor aneuploidy and evaluates...
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RT @UCCancerCenter: 🌟 In a new study, Huang et al., emphasizes on combining immunotherapy with radiation that may overcome therapy resistan….
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RT @LiamSpurrMD: Check out our new perspective in @NatureGenet exploring the role of #aneuploidy in predicting outcomes following treatment….
nature.com
Nature Genetics - Aneuploidy, a defining feature of cancer, is linked to immune evasion and therapeutic resistance. This Perspective reviews approaches to quantify tumor aneuploidy and evaluates...
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11/.Special thanks to @UCCancerCenter @UChicagoMed @UChicago @UChicagoRadonc @Ludwig_Cancer @LUNGevity.
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10/.Read the full Perspective by Daniel Huang, @liamspurr, @rweichselbaum, and @SeanPitroda .👉 Let’s bring tumor aneuploidy from bench to bedside. #oncology #immunotherapy #radiationoncology #precisionmedicine.
nature.com
Nature Genetics - Aneuploidy, a defining feature of cancer, is linked to immune evasion and therapeutic resistance. This Perspective reviews approaches to quantify tumor aneuploidy and evaluates...
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9/.Key takeaways:.🔹 Aneuploidy is a powerful biomarker—both prognostic & predictive.🔹 It can help personalize ICB-based therapy.🔹 Combining genomic features (aneuploidy, TMB, PD-L1) is the future.🔹 Prospective trials incorporating aneuploidy are urgently needed.
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8/.Why it matters:.✔️ Aneuploidy is quantifiable from genomic data.✔️ Independent of TMB/PD-L1.✔️ Guides treatment escalation (e.g., SABR, dual-ICB).✔️ May help identify patients for de-escalation too.📌Aneuploidy isn’t just noise—it's clinically actionable signal.
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7/.🧠 Aneuploid tumors are also biologically vulnerable. Example: CIN-high cancers depend on the mitotic motor protein KIF18A. Targeting this dependency (e.g., with KIF18A inhibitors) shows promise in preclinical models. This opens new therapeutic windows.
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6/.Aneuploidy may inform treatment beyond metastatic settings:.➡️ Locally advanced NSCLC (PACIFIC regimen).➡️ Early-stage NSCLC (e.g., SABR + ICB trials).➡️ Neoadjuvant chemo-ICB strategies.Tailoring therapy intensity based on AS (aneuploidy score) could optimize outcomes.
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