Sean Burnap
@SeanBurnap
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Postdoc Struwe lab | University of Oxford | Cardiovascular Proteomics PhD
Oxford
Joined December 2012
RT @lmhoxford: 🗞️ Dobson Junior Research Fellow in Molecular Biophysics Dr Sean Burnap has been awarded a Wellcome Early Career Award to su….
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RT @KavliOxford: #MeetTheResearcher.Happy to introduce Sean Burnap from the Struwe Group this week! Sean is a postdoctoral researcher who w….
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RT @KavliOxford: Meet us at the University Parks on Sunday the 12th of May, at 10 am, to support our super star researchers who will be run….
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RT @ESIBDLab: Position available: SPM imaging of biological molecules: glycans, proteins, DNA. @WestonStruwe @ESIBDLab . Apply here: https….
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RT @KavliOxford: #KavliOxford is delighted to announce the appointment of @WestonStruwe as an Associate Professor of Cellular and Molecular….
kavli.web.ox.ac.uk
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RT @KavliOxford: Exciting News! #KavliOxford researchers have secured funding from @UKRI_News BBSRC for cutting-edge equipment, propelling….
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RT @savitski_lab: We are happy to present our workflow DQGlyco enabling the in-depth quantification of glycoproteome dynamics. In total, we….
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RT @Vascular_Prot: Excited to share @SeanBurnap's latest work in our lab, about the interactions between SARS-CoV-2 spike protein and high-….
www.mcponline.org
In BriefHere we utilized cross-linking mass spectrometry (XL-MS) to investigate circulating protein interaction networks in the context of SARS-CoV-2. The spike glycoprotein was determined to...
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A massive thank you to our collaborators, particularly @KaloyanTakov and of course the Mayr lab @Vascular_Prot. 7/7.
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However, to our surprise, ApoD overexpression failed to influence SARS-CoV-2 replication and infection in cell-based assays. 6/7.
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Computational structural modelling utilising #HADDOCK docking and #AlphaFold confirmed ApoD to interact with the RBD of the SARS-CoV-2 spike protein. 5/7.
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XL-MS upon SARS-CoV-2 spike and HDL identified multiple spike interactions, including an interaction between the receptor-binding domain #RBD and ApoD, that was confirmed through affinity purification MS. 4/7.
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#COVID19 patient plasma XL-MS uncovered acute-phase protein interaction networks involving HDL-associated proteins, including ApoD. 3/7.
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We had previously identified the HDL-associated Apolipoprotein-D to potentially interact with SARS-CoV-2 spike and sought to structurally and functionally characterise this association. 2/7.
www.nature.com
Nature Communications - Here the authors use RT-qPCR and mass spectrometry to analyze longitudinal blood samples from intensive care unit (ICU) COVID-19 patients and controls. They find that viral...
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Delighted to share perhaps the last of my work to come from my time in the Mayr lab @Vascular_Prot. Here we used cross-linking mass spectrometry #XLMS to uncover interactions between the SARS-CoV-2 spike protein and high-density lipoproteins #HDL. 🧵1/7.
www.mcponline.org
In BriefHere we utilized cross-linking mass spectrometry (XL-MS) to investigate circulating protein interaction networks in the context of SARS-CoV-2. The spike glycoprotein was determined to...
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RT @liangford: Quick bump on the below 👇 we are looking for a pdra to apply protein labelling methods to aid cryoEM of #glycotime biosynthe….
opportunities.rfi.ac.uk
The Rosalind Franklin Institute is a new national institute, announced in 2017 by the UK government, dedicated to bringing about transformative changes in life science through interdisciplinary...
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RT @refeynit: Informing #vaccinedevelopment: @WestonStruwe & @SeanBurnap at @KavliOxford & @OxfordChemistry used #MassPhotometry to show th….
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RT @Vascular_Prot: Read our latest #research by E. Duregotti on the contribution of reduced secretion of Negr1 to #adipose - #neuronal cros….
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