Sean Burnap
@SeanBurnap
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Postdoc Struwe lab | University of Oxford | Cardiovascular Proteomics PhD
Oxford
Joined December 2012
🗞️ Dobson Junior Research Fellow in Molecular Biophysics Dr Sean Burnap has been awarded a Wellcome Early Career Award to support his research project into Filovirus-host interactions. Head to https://t.co/AgNkc9DsPY to find out more🔗 #LadyMargaretHall #LMH #UniversityOfOxford
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#MeetTheResearcher Happy to introduce Sean Burnap from the Struwe Group this week! Sean is a postdoctoral researcher who was recently awarded the @wellcometrust Early Career Fellowship for his research on filovirus-host interactions.
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Meet us at the University Parks on Sunday the 12th of May, at 10 am, to support our super star researchers who will be running the Town and Gown 10K! @MDUK_News
#KavliOxford
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Position available: SPM imaging of biological molecules: glycans, proteins, DNA. @WestonStruwe @ESIBDLab Apply here: https://t.co/IddWDPqE0H ... or be in touch for more information. #STM #AFM #MassSpec
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#KavliOxford is delighted to announce the appointment of @WestonStruwe as an Associate Professor of Cellular and Molecular Biochemistry and Tutorial Fellow at @WorcCollegeOx. https://t.co/bIaup6t0l1
@BiochemOxford
@UniofOxford
@KavliFoundation
@OxfordMedSci
kavli.web.ox.ac.uk
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Exciting News! #KavliOxford researchers have secured funding from @UKRI_News BBSRC for cutting-edge equipment, propelling groundbreaking research in cellular and biomolecular analysis. Details here👇 https://t.co/sTZgPdtu4l
@KavliFoundation
@mplsoxford
@OxfordMedSci
@UniofOxford
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Theofilatos et al found that proteomic signatures of #plaque composition were found to predict long-term, adverse CV events, improving risk stratification for patients with advanced #atherosclerosis. https://t.co/wl0QYIVJM6
@k_theofilatos @Vascular_Prot @swvanderlaaan
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We are happy to present our workflow DQGlyco enabling the in-depth quantification of glycoproteome dynamics. In total, we characterize > 150,000 glycoforms in the mouse brain. https://t.co/hRDnvzORkS
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Excited to share @SeanBurnap's latest work in our lab, about the interactions between SARS-CoV-2 spike protein and high-density lipoproteins! #XLMS #HDL
https://t.co/NJ2VDwxOi9
mcponline.org
In BriefHere we utilized cross-linking mass spectrometry (XL-MS) to investigate circulating protein interaction networks in the context of SARS-CoV-2. The spike glycoprotein was determined to...
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A massive thank you to our collaborators, particularly @KaloyanTakov and of course the Mayr lab @Vascular_Prot. 7/7
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However, to our surprise, ApoD overexpression failed to influence SARS-CoV-2 replication and infection in cell-based assays. 6/7
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Computational structural modelling utilising #HADDOCK docking and #AlphaFold confirmed ApoD to interact with the RBD of the SARS-CoV-2 spike protein. 5/7
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XL-MS upon SARS-CoV-2 spike and HDL identified multiple spike interactions, including an interaction between the receptor-binding domain #RBD and ApoD, that was confirmed through affinity purification MS. 4/7
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#COVID19 patient plasma XL-MS uncovered acute-phase protein interaction networks involving HDL-associated proteins, including ApoD. 3/7
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We had previously identified the HDL-associated Apolipoprotein-D to potentially interact with SARS-CoV-2 spike and sought to structurally and functionally characterise this association. https://t.co/blbupuLooJ. 2/7
nature.com
Nature Communications - Here the authors use RT-qPCR and mass spectrometry to analyze longitudinal blood samples from intensive care unit (ICU) COVID-19 patients and controls. They find that viral...
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Delighted to share perhaps the last of my work to come from my time in the Mayr lab @Vascular_Prot. Here we used cross-linking mass spectrometry #XLMS to uncover interactions between the SARS-CoV-2 spike protein and high-density lipoproteins #HDL. https://t.co/JxxaPSMjqT 🧵1/7
mcponline.org
In BriefHere we utilized cross-linking mass spectrometry (XL-MS) to investigate circulating protein interaction networks in the context of SARS-CoV-2. The spike glycoprotein was determined to...
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Quick bump on the below 👇 we are looking for a pdra to apply protein labelling methods to aid cryoEM of #glycotime biosynthesis inside cells. Closing next week 10th. Contact me for more details
opportunities.rfi.ac.uk
The Rosalind Franklin Institute is a new national institute, announced in 2017 by the UK government, dedicated to bringing about transformative changes in life science through interdisciplinary...
In other news, I have an opening for a PDRA in my group @RosFrankInst
https://t.co/u96lzxxDsx Job is to apply (bio)chemical protein labelling methods to aid cryo-EM and ET imaging. End goal is to see #glycotime machinery working inside cells. Contact me for details. Pls share
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Read our latest #research by E. Duregotti on the contribution of reduced secretion of Negr1 to #adipose - #neuronal crosstalk in #obesity, published with @SpringerNature in @NatureComms!👇 https://t.co/2Cat8nGcft
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