Webster Santos
@santoslabVT
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Professor & COS Faculty Fellow, Mito Uncouplers, Sph Kinase & S1P transport inhibitors. B & Si Methods. Co-Fndr: ContinuumBio, S1P Therapeutics, UncouplerBio
Blacksburg, VA
Joined March 2015
Matthew Dupuis, a graduate student in the @santoslabVT, competed in the Nutshell Games! Listen to his pitch on his medicinal chemistry research that focuses on treating highly resistant, deadly fungal infections 👉 https://t.co/7qc90FEbfW
#vtchem #commscivt
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Catalytic Stereoselective Silyl- and Boraformylations: Charting a Challenging Road Ahead (@angew_chem): https://t.co/rTvLduJoAG.
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Stable BF₂ Boracycles as Versatile Reagents for Selective Ortho C–H Functionalization (@ChemRxiv): https://t.co/NAH8evJHg5 (@sundenlab, @GaneshDFB).
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Spin Delocalization of Nitrile-Ligated Diarylboryl Radicals Enables Photochemical Boracycle Synthesis via N-Borylimidoyl Radicals (@JuntaoYe): https://t.co/haPNwzi78z (@J_A_C_S).
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Persistent Boryl Radicals as Highly Reducing Photoredox Catalysts for Debrominative Borylations (@J_A_C_S): https://t.co/JdTBow3ErH (@AggarwalLab).
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Xanthopinacol Boronate: A Robust, Photochemically Assembled and Cleavable Boronic Ester for Orthogonal Chemistry (@HallBoronLab): https://t.co/DoEJUTwWzX (@angew_chem).
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Mapping Boryl Radical Properties and Reactivity Using Machine Learning: the B-rad and React-B-rad maps (@ChemRxiv): https://t.co/w4E4k6bwl2.
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Synthesis of gem-di(boryl)cyclopropanes from non-activated olefins via Mn-photocatalyzed atom transfer radical addition (@ChemicalScience): https://t.co/txQYjOZJM0.
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Boronate Formation-Triggered Azide–Alkyne Cycloaddition (@JOC_OL): https://t.co/VK2dPQNqnC (@yuukiwomanabu).
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The impressive surge of recent papers on BCB chemistry is evident in this review 📚: Catalytic Asymmetric Strategies for Bicyclo[1.1.0]butane Transformations: Advances and Applications | CCS Chemistry
chinesechemsoc.org
Owing to their diverse reactivity resulting from their inherent high strain energy, bicyclo[1.1.0]butanes (BCBs) have garnered increasing attention as versatile building blocks for constructing...
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Congrats to @santoslabVT PhD #31: Dr. Joseph Quinlan. He is our antivirulence/antiobesity guru targeting PilB and mitochondria. #medchem 🙌💪 @VTChemDept @VT_Science @FralinLifeSci
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Congratulations to our 2025 VT Center for Drug Discovery @drugdisc_vt poster session winners: Darwin Gomez (@SEE_adrian_figg), Emily Krinos (@santoslabVT) & Ahmed Abouelkhair (@SeleemLab). 🙌 @FralinLifeSci @VT_Science
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Congrats to @santoslabVT PhD #30: Dr. Mary Foutz @maryolson222. She developed oral mitochondrial uncouplers for the treatment of #obesity. #drughunter 👏🙌 @VTChemDept @VT_Science @drugdisc_vt @FralinLifeSci
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Photoinduced transition metal-free borylation of aryl halides in an aqueous phase (@green_rsc): https://t.co/QJrs5TPek9.
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Copper-Mediated Phosphoniumation of Aryl/Vinyl Boronic Acids (@JOC_OL): https://t.co/sIxYbOQDWW.
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Regiodivergent Alkylation of Pyridines: Alkyllithium Clusters Direct Chemical Reactivity | Journal of the American Chemical Society @kaistpr @KAIST_Chem @postech2020 @IBS_media @TotalSyntheses
pubs.acs.org
Regiodivergent C–C bond-forming reactions are a powerful tool for constructing diverse molecular architectures from common precursors. While transition metal catalysis has dominated regioselective...
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Congrats to @santoslabVT newest Ph.D. candidate Mario Hernandez @marioooohdez. Breezed through prelim exam. Will now slay #Spns2 as a drug target 🎯. 🙌 @VTChemDept
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