Samantha Zepeda
@Sam_K_Zepeda
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Joined August 2020
RT @veeslerlab: Can we leverage recent developments in machine-learning & protein design to tackle previously intractable challenges?. The….
biorxiv.org
In the absence of effective vaccines, human-infecting members of the Herpesvirus family cause considerable morbidity and mortality worldwide. Herpesvirus infection relies on receptor engagement by a...
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RT @veeslerlab: Are you passionate about designing vaccines against viruses and understanding how they work at the molecular level? We're h….
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Blazing-fast image creation – using just your voice. Try Grok Imagine.
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So grateful for the opportunity to share my work on bat borne Sarbecoviruses at the Rising Stars symposium @UofUBiochem. Excited to hear all the other amazing work being done!.
Looking forward to meeting everybody at our @UofUBiochem @uofunuip third Graduate Student Rising Stars Synposium! All Utah colleagues, come and enjoy some exciting science and good times.
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RT @cellhostmicrobe: Receptor tropism & immunogenicity of bat-borne sarbecovirus. @veeslerlab @0327jimin @Sam_K_Zepeda show PRD-0038 clade….
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RT @veeslerlab: Delighted to share the peer-reviewed version of our article investigating bat-borne sarbecovirus interactions with ACE2 hos….
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RT @veeslerlab: How do bat-borne sarbecoviruses (i.e. SARS-CoV-1/2-like viruses) interact with host receptors and are we ready for a possi….
biorxiv.org
Although Rhinolophus bats harbor diverse clade 3 sarbecoviruses, the structural determinants of receptor tropism along with the antigenicity of their spike (S) glycoproteins remain uncharacterized....
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RT @tylernstarr: There's also a nice write-up of the story from Sabrina Richards @fredhutch!
fredhutch.org
Scientists at Fred Hutchinson Cancer Research Center dove deep into the evolutionary past of SARS-related coronaviruses to reveal when the ability to use ACE2 to enter host cells emerged. Their...
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RT @veeslerlab: Can we correlate #SARSCoV2 spike (S) biochemical properties with the specificity, magnitude & quality of antibody responses….
biorxiv.org
Numerous safe and effective COVID-19 vaccines have been developed that utilize various delivery technologies and engineering strategies. The influence of the SARS-CoV-2 spike (S) glycoprotein...
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RT @veeslerlab: We characterized the structural basis of #SARSCoV2 #OmicronVariant binding to the host ACE2 receptor and neutralization by….
biorxiv.org
The SARS-CoV-2 Omicron variant of concern evades antibody mediated immunity with an unprecedented magnitude due to accumulation of numerous spike mutations. To understand the Omicron antigenic shift,...
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RT @Nature: Nature research paper: Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift
nature.com
Nature - Pseudovirus assays and surface plasmon resonance show that the Omicron receptor-binding domain binds to human ACE2 with increased affinity relative to the ancestral virus, and that most...
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RT @veeslerlab: Our manuscript on eliciting broadly protective sarbecovirus immunity using mosaic nanoparticle RBD vaccines has been peer-r….
cell.com
A clinical stage multivalent SARS-CoV-2 spike receptor-binding domain nanoparticle (RBD-NP) vaccine is protective in mice after a single immunization and elicits strong antibody responses across...
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Virus-encoded histone doublets are essential and form nucleosome-like .
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RT @NaturePortfolio: A paper in @Nature reports the characterization of a human monoclonal antibody against SARS-CoV-2 that is able to neut….
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RT @tylernstarr: Excited to share our preprint demonstrating that ACE2 binding is a deep ancestral trait of sarbecoviruses with plastic evo….
biorxiv.org
Two different sarbecoviruses have caused major human outbreaks in the last two decades[1][1],[2][2]. Both these sarbecoviruses, SARS-CoV-1 and SARS-CoV-2, engage ACE2 via the spike receptor-binding...
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